GLUT4 in murine bone growth: from uptake and translocation to proliferation and differentiation

Skeletal growth, taking place in the cartilaginous growth plates of long bones, consumes high levels of glucose for both metabolic and anabolic purposes. We previously showed that Glut4 is present in growing bone and is decreased in diabetes. In the present study, we examined the hypothesis that in...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2011-04, Vol.300 (4), p.E613-E623
Hauptverfasser:	Maor, Gila, Vasiliver-Shamis, Gaia, Hazan-Brill, Roni, Wertheimer, Efrat, Karnieli, Eddy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Development - genetics Bone Development - physiology Bones Cell Culture Techniques Cell Differentiation - genetics Cell Differentiation - physiology Cell Proliferation Cells Cells, Cultured Gene expression Glucose Glucose - pharmacokinetics Glucose Transporter Type 4 - genetics Glucose Transporter Type 4 - metabolism Glucose Transporter Type 4 - physiology Insulin Insulin - metabolism Insulin - pharmacology Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor I - pharmacology Mandibular Condyle - cytology Mandibular Condyle - metabolism Metabolism Mice Mice, Inbred ICR Protein Transport - genetics Protein Transport - physiology Proteins Receptor, IGF Type 1 - metabolism Receptor, IGF Type 1 - physiology Rodents Signal Transduction - drug effects Signal Transduction - genetics Signal Transduction - physiology
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