BZM055, an Iodinated Radiotracer Candidate for PET and SPECT Imaging of Myelin and FTY720 Brain Distribution

FTY720 (fingolimod, Gilenya®) is a sphingosine 1‐phosphate (S1P) receptor modulator that shows significant therapeutic efficacy after oral administration to patients of multiple sclerosis. Because FTY720 does not contain any atom whose PET or SPECT radioisotope would have a half‐life compatible with...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	ChemMedChem 2011-04, Vol.6 (4), p.667-677
Hauptverfasser:	Briard, Emmanuelle, Orain, David, Beerli, Christian, Billich, Andreas, Streiff, Markus, Bigaud, Marc, Auberson, Yves P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - diagnostic imaging Brain - metabolism Brain - pathology Humans imaging agents iodine Iodine Radioisotopes - chemistry Kinetics Multiple Sclerosis - metabolism Multiple Sclerosis - pathology myelin Myelin Sheath - diagnostic imaging Myelin Sheath - metabolism Myelin Sheath - pathology Phosphorylation positron emission tomography Positron-Emission Tomography - methods Radiography Receptors, Lysosphingolipid - metabolism Tomography, Emission-Computed, Single-Photon - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!