Analgesic Effects of Tramadol, Tramadol-Gabapentin, and Buprenorphine in an Incisional Model of Pain in Rats (Rattus norvegicus)
Postoperative pain management in laboratory animals relies heavily on a limited number of drug classes, such as opioids and nonsteroidal antiinflammatory drugs. Here we evaluated the effects of saline, tramadol, tramadol with gabapentin, and buprenorphine (n = 6 per group) in a rat model of incision...
Gespeichert in:
| Veröffentlicht in: | Journal of the American Association for Laboratory Animal Science 2011-03, Vol.50 (2), p.192-197 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 197 |
|---|---|
| container_issue | 2 |
| container_start_page | 192 |
| container_title | Journal of the American Association for Laboratory Animal Science |
| container_volume | 50 |
| creator | McKeon, Gabriel P Pacharinsak, Cholawat Long, Charles T Howard, Antwain M Jampachaisri, Katechan Yeomans, David C Felt, Stephen A |
| description | Postoperative pain management in laboratory animals relies heavily on a limited number of drug classes, such as opioids and nonsteroidal antiinflammatory drugs. Here we evaluated the effects of saline, tramadol, tramadol with gabapentin, and buprenorphine (n = 6 per group) in
a rat model of incisional pain by examining thermal hyperalgesia and weight-bearing daily for 6 d after surgery. All drugs were administered preemptively and continued for 2 consecutive days after surgery. Rats treated with saline or with tramadol only showed thermal hyperalgesia on days 1
through 4 and 1 through 3 after surgery, respectively. In contrast, buprenorphine-treated rats showed no thermal hyperalgesia on days 1 and 2 after surgery, and rats given tramadol with gabapentin showed reduced thermal hyperalgesia on days 2 and 4. For tests of weight-bearing, rats treated
with saline or with tramadol only showed significantly less ipsilateral weight-bearing on day 1 after surgery, whereas rats given either buprenorphine or tramadol with gabapentin showed no significant change in ipsilateral weight-bearing after surgery. These data suggest that tramadol alone
provides insufficient analgesia in this model of incisional pain; buprenorphine and, to a lesser extent, tramadol with gabapentin provide relief of thermal hyperalgesia and normalize weight-bearing. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_ingen</sourceid><recordid>TN_cdi_proquest_miscellaneous_859053268</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ingid>aalas/jaalas/2011/00000050/00000002/art00006</ingid><sourcerecordid>859053268</sourcerecordid><originalsourceid>FETCH-LOGICAL-i398t-43e15a26dc2f0e507c801b41a30250d39ec88043f9023dedb2c2e8602181e85b3</originalsourceid><addsrcrecordid>eNp1ksFu1DAQhnMA0VJ4BZQbIDXS2I6zzgWptKVUKipC5WxN7EnqVdYOdrISnHj0ertLBQcsyzPyjL9f_jXPimMmZVs1DNqj4mVKawC5koK_KI44q0XLGT8ufp95HAdKzpSXfU9mTmXoy7uIG7RhPH3KqivscCI_O39aorflx2WK5EOc7p2n0vl8WV5745ILmVh-CZbGHeor5lre3zCj3-VzXlKZ321pcGZJ718Vz3scE70-xJPi-6fLu_PP1c3t1fX52U3lRKvmqhbEJPLGGt4DSVgZBayrGQrgEqxoySgFtehb4MKS7bjhpBrgTDFSshMnxYc9d1q6DVmTvxJx1FN0G4w_dUCn_614d6-HsNUCGlazNgPeHgAx_FgozXrjkqFxRE9hSVrJFrK7jcqdb_6WetL443puuNg3OD9kNdTrsMTsWtKIIya93gcOjGl4XBIOCXCNcd4lTcbc_gfjzIG0m4DdAOitBM8zkTNQbKUZq1ttqcdlnPWMUQ-_dGrEA8SPrrQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>859053268</pqid></control><display><type>article</type><title>Analgesic Effects of Tramadol, Tramadol-Gabapentin, and Buprenorphine in an Incisional Model of Pain in Rats (Rattus norvegicus)</title><source>MEDLINE</source><source>IngentaConnect Open Access Journals</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><creator>McKeon, Gabriel P ; Pacharinsak, Cholawat ; Long, Charles T ; Howard, Antwain M ; Jampachaisri, Katechan ; Yeomans, David C ; Felt, Stephen A</creator><creatorcontrib>McKeon, Gabriel P ; Pacharinsak, Cholawat ; Long, Charles T ; Howard, Antwain M ; Jampachaisri, Katechan ; Yeomans, David C ; Felt, Stephen A</creatorcontrib><description>Postoperative pain management in laboratory animals relies heavily on a limited number of drug classes, such as opioids and nonsteroidal antiinflammatory drugs. Here we evaluated the effects of saline, tramadol, tramadol with gabapentin, and buprenorphine (n = 6 per group) in
a rat model of incisional pain by examining thermal hyperalgesia and weight-bearing daily for 6 d after surgery. All drugs were administered preemptively and continued for 2 consecutive days after surgery. Rats treated with saline or with tramadol only showed thermal hyperalgesia on days 1
through 4 and 1 through 3 after surgery, respectively. In contrast, buprenorphine-treated rats showed no thermal hyperalgesia on days 1 and 2 after surgery, and rats given tramadol with gabapentin showed reduced thermal hyperalgesia on days 2 and 4. For tests of weight-bearing, rats treated
with saline or with tramadol only showed significantly less ipsilateral weight-bearing on day 1 after surgery, whereas rats given either buprenorphine or tramadol with gabapentin showed no significant change in ipsilateral weight-bearing after surgery. These data suggest that tramadol alone
provides insufficient analgesia in this model of incisional pain; buprenorphine and, to a lesser extent, tramadol with gabapentin provide relief of thermal hyperalgesia and normalize weight-bearing.</description><identifier>ISSN: 1559-6109</identifier><identifier>PMID: 21439212</identifier><language>eng</language><publisher>United States: American Association for Laboratory Animal Science</publisher><subject>Amines - pharmacology ; Analgesics - pharmacology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Buprenorphine - pharmacology ; Cyclohexanecarboxylic Acids - pharmacology ; Experimental Use ; gamma-Aminobutyric Acid - pharmacology ; Hyperalgesia ; Male ; Models, Animal ; Pain, Postoperative - drug therapy ; Pain, Postoperative - veterinary ; Postoperative Period ; Rats ; Rats, Sprague-Dawley ; Tramadol - pharmacology ; Weight-Bearing</subject><ispartof>Journal of the American Association for Laboratory Animal Science, 2011-03, Vol.50 (2), p.192-197</ispartof><rights>American Association for Laboratory Animal Science 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061419/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061419/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,288,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21439212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McKeon, Gabriel P</creatorcontrib><creatorcontrib>Pacharinsak, Cholawat</creatorcontrib><creatorcontrib>Long, Charles T</creatorcontrib><creatorcontrib>Howard, Antwain M</creatorcontrib><creatorcontrib>Jampachaisri, Katechan</creatorcontrib><creatorcontrib>Yeomans, David C</creatorcontrib><creatorcontrib>Felt, Stephen A</creatorcontrib><title>Analgesic Effects of Tramadol, Tramadol-Gabapentin, and Buprenorphine in an Incisional Model of Pain in Rats (Rattus norvegicus)</title><title>Journal of the American Association for Laboratory Animal Science</title><addtitle>J Am Assoc Lab Animal Sci</addtitle><addtitle>J Am Assoc Lab Anim Sci</addtitle><description>Postoperative pain management in laboratory animals relies heavily on a limited number of drug classes, such as opioids and nonsteroidal antiinflammatory drugs. Here we evaluated the effects of saline, tramadol, tramadol with gabapentin, and buprenorphine (n = 6 per group) in
a rat model of incisional pain by examining thermal hyperalgesia and weight-bearing daily for 6 d after surgery. All drugs were administered preemptively and continued for 2 consecutive days after surgery. Rats treated with saline or with tramadol only showed thermal hyperalgesia on days 1
through 4 and 1 through 3 after surgery, respectively. In contrast, buprenorphine-treated rats showed no thermal hyperalgesia on days 1 and 2 after surgery, and rats given tramadol with gabapentin showed reduced thermal hyperalgesia on days 2 and 4. For tests of weight-bearing, rats treated
with saline or with tramadol only showed significantly less ipsilateral weight-bearing on day 1 after surgery, whereas rats given either buprenorphine or tramadol with gabapentin showed no significant change in ipsilateral weight-bearing after surgery. These data suggest that tramadol alone
provides insufficient analgesia in this model of incisional pain; buprenorphine and, to a lesser extent, tramadol with gabapentin provide relief of thermal hyperalgesia and normalize weight-bearing.</description><subject>Amines - pharmacology</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Buprenorphine - pharmacology</subject><subject>Cyclohexanecarboxylic Acids - pharmacology</subject><subject>Experimental Use</subject><subject>gamma-Aminobutyric Acid - pharmacology</subject><subject>Hyperalgesia</subject><subject>Male</subject><subject>Models, Animal</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Pain, Postoperative - veterinary</subject><subject>Postoperative Period</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tramadol - pharmacology</subject><subject>Weight-Bearing</subject><issn>1559-6109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ksFu1DAQhnMA0VJ4BZQbIDXS2I6zzgWptKVUKipC5WxN7EnqVdYOdrISnHj0ertLBQcsyzPyjL9f_jXPimMmZVs1DNqj4mVKawC5koK_KI44q0XLGT8ufp95HAdKzpSXfU9mTmXoy7uIG7RhPH3KqivscCI_O39aorflx2WK5EOc7p2n0vl8WV5745ILmVh-CZbGHeor5lre3zCj3-VzXlKZ321pcGZJ718Vz3scE70-xJPi-6fLu_PP1c3t1fX52U3lRKvmqhbEJPLGGt4DSVgZBayrGQrgEqxoySgFtehb4MKS7bjhpBrgTDFSshMnxYc9d1q6DVmTvxJx1FN0G4w_dUCn_614d6-HsNUCGlazNgPeHgAx_FgozXrjkqFxRE9hSVrJFrK7jcqdb_6WetL443puuNg3OD9kNdTrsMTsWtKIIya93gcOjGl4XBIOCXCNcd4lTcbc_gfjzIG0m4DdAOitBM8zkTNQbKUZq1ttqcdlnPWMUQ-_dGrEA8SPrrQ</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>McKeon, Gabriel P</creator><creator>Pacharinsak, Cholawat</creator><creator>Long, Charles T</creator><creator>Howard, Antwain M</creator><creator>Jampachaisri, Katechan</creator><creator>Yeomans, David C</creator><creator>Felt, Stephen A</creator><general>American Association for Laboratory Animal Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110301</creationdate><title>Analgesic Effects of Tramadol, Tramadol-Gabapentin, and Buprenorphine in an Incisional Model of Pain in Rats (Rattus norvegicus)</title><author>McKeon, Gabriel P ; Pacharinsak, Cholawat ; Long, Charles T ; Howard, Antwain M ; Jampachaisri, Katechan ; Yeomans, David C ; Felt, Stephen A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i398t-43e15a26dc2f0e507c801b41a30250d39ec88043f9023dedb2c2e8602181e85b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Amines - pharmacology</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Buprenorphine - pharmacology</topic><topic>Cyclohexanecarboxylic Acids - pharmacology</topic><topic>Experimental Use</topic><topic>gamma-Aminobutyric Acid - pharmacology</topic><topic>Hyperalgesia</topic><topic>Male</topic><topic>Models, Animal</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Pain, Postoperative - veterinary</topic><topic>Postoperative Period</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tramadol - pharmacology</topic><topic>Weight-Bearing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McKeon, Gabriel P</creatorcontrib><creatorcontrib>Pacharinsak, Cholawat</creatorcontrib><creatorcontrib>Long, Charles T</creatorcontrib><creatorcontrib>Howard, Antwain M</creatorcontrib><creatorcontrib>Jampachaisri, Katechan</creatorcontrib><creatorcontrib>Yeomans, David C</creatorcontrib><creatorcontrib>Felt, Stephen A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American Association for Laboratory Animal Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McKeon, Gabriel P</au><au>Pacharinsak, Cholawat</au><au>Long, Charles T</au><au>Howard, Antwain M</au><au>Jampachaisri, Katechan</au><au>Yeomans, David C</au><au>Felt, Stephen A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analgesic Effects of Tramadol, Tramadol-Gabapentin, and Buprenorphine in an Incisional Model of Pain in Rats (Rattus norvegicus)</atitle><jtitle>Journal of the American Association for Laboratory Animal Science</jtitle><stitle>J Am Assoc Lab Animal Sci</stitle><addtitle>J Am Assoc Lab Anim Sci</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>50</volume><issue>2</issue><spage>192</spage><epage>197</epage><pages>192-197</pages><issn>1559-6109</issn><abstract>Postoperative pain management in laboratory animals relies heavily on a limited number of drug classes, such as opioids and nonsteroidal antiinflammatory drugs. Here we evaluated the effects of saline, tramadol, tramadol with gabapentin, and buprenorphine (n = 6 per group) in
a rat model of incisional pain by examining thermal hyperalgesia and weight-bearing daily for 6 d after surgery. All drugs were administered preemptively and continued for 2 consecutive days after surgery. Rats treated with saline or with tramadol only showed thermal hyperalgesia on days 1
through 4 and 1 through 3 after surgery, respectively. In contrast, buprenorphine-treated rats showed no thermal hyperalgesia on days 1 and 2 after surgery, and rats given tramadol with gabapentin showed reduced thermal hyperalgesia on days 2 and 4. For tests of weight-bearing, rats treated
with saline or with tramadol only showed significantly less ipsilateral weight-bearing on day 1 after surgery, whereas rats given either buprenorphine or tramadol with gabapentin showed no significant change in ipsilateral weight-bearing after surgery. These data suggest that tramadol alone
provides insufficient analgesia in this model of incisional pain; buprenorphine and, to a lesser extent, tramadol with gabapentin provide relief of thermal hyperalgesia and normalize weight-bearing.</abstract><cop>United States</cop><pub>American Association for Laboratory Animal Science</pub><pmid>21439212</pmid><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1559-6109 |
| ispartof | Journal of the American Association for Laboratory Animal Science, 2011-03, Vol.50 (2), p.192-197 |
| issn | 1559-6109 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_859053268 |
| source | MEDLINE; IngentaConnect Open Access Journals; PubMed Central; EZB Electronic Journals Library |
| subjects | Amines - pharmacology Analgesics - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Buprenorphine - pharmacology Cyclohexanecarboxylic Acids - pharmacology Experimental Use gamma-Aminobutyric Acid - pharmacology Hyperalgesia Male Models, Animal Pain, Postoperative - drug therapy Pain, Postoperative - veterinary Postoperative Period Rats Rats, Sprague-Dawley Tramadol - pharmacology Weight-Bearing |
| title | Analgesic Effects of Tramadol, Tramadol-Gabapentin, and Buprenorphine in an Incisional Model of Pain in Rats (Rattus norvegicus) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T19%3A28%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_ingen&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analgesic%20Effects%20of%20Tramadol,%20Tramadol-Gabapentin,%20and%20Buprenorphine%20in%20an%20Incisional%20Model%20of%20Pain%20in%20Rats%20(Rattus%20norvegicus)&rft.jtitle=Journal%20of%20the%20American%20Association%20for%20Laboratory%20Animal%20Science&rft.au=McKeon,%20Gabriel%20P&rft.date=2011-03-01&rft.volume=50&rft.issue=2&rft.spage=192&rft.epage=197&rft.pages=192-197&rft.issn=1559-6109&rft_id=info:doi/&rft_dat=%3Cproquest_ingen%3E859053268%3C/proquest_ingen%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=859053268&rft_id=info:pmid/21439212&rft_ingid=aalas/jaalas/2011/00000050/00000002/art00006&rfr_iscdi=true |