Linking cell polarity, aging and rejuvenation
Cell polarity is a universal biological phenomenon. While much is known about the establishment and maintenance of cell polarity, its role in aging and age-related diseases remains to be fully addressed. Nonetheless, the exciting findings in the budding yeast indicate that the polar processes are in...
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| Veröffentlicht in: | Biogerontology (Dordrecht) 2011-04, Vol.12 (2), p.167-175 |
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| creator | Budovsky, Arie Fraifeld, Vadim E. Aronov, Stella |
| description | Cell polarity is a universal biological phenomenon. While much is known about the establishment and maintenance of cell polarity, its role in aging and age-related diseases remains to be fully addressed. Nonetheless, the exciting findings in the budding yeast indicate that the polar processes are intimately linked to both aging of the mother cell and rejuvenation of the daughter cell. This includes polar segregation of damaged proteins and ERCs due to the septin-based diffusion barrier, asymmetric inheritance of MDR proteins and retrograde protein transport. The principal, still unexplored question is whether the same polar mechanisms work during the asymmetric division of germ and stem cells, allowing their rejuvenation across generations. Further strengthening the links between cell polarity and aging is a large number of common genes associated with both polarity and longevity. Given a strong similarity between mechanisms of cell polarity in yeast and higher eukaryotes, the budding yeast
Saccharomyces cerevisiae
could serve as a convenient model system for studying the links between the cell polarity, aging and rejuvenation. Consequently, exploring the potential mammalian equivalents of yeast-established polarity mechanisms could be the focus for future biogerontological investigations. |
| doi_str_mv | 10.1007/s10522-010-9305-4 |
| format | Article |
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Saccharomyces cerevisiae
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Saccharomyces cerevisiae
could serve as a convenient model system for studying the links between the cell polarity, aging and rejuvenation. Consequently, exploring the potential mammalian equivalents of yeast-established polarity mechanisms could be the focus for future biogerontological investigations.</description><subject>Aging</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cell Polarity</subject><subject>Daughters</subject><subject>Development. Metamorphosis. Moult. Ageing</subject><subject>Developmental Biology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Geriatrics/Gerontology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Opinion</subject><subject>Proteins</subject><subject>Rejuvenation</subject><subject>Ribosomal DNA</subject><subject>Saccharomyces cerevisiae - cytology</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - physiology</subject><subject>Saccharomyces cerevisiae Proteins - genetics</subject><subject>Saccharomyces cerevisiae Proteins - metabolism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Yeast</subject><issn>1389-5729</issn><issn>1573-6768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kFtLxDAQhYMo3n-AL7II4ovRyT19FPEGC77oc5i26dK1m67JVvDfm7KrguBDmDDzzZnDIeSEwRUDMNeJgeKcAgNaCFBUbpF9poyg2mi7nf_CFlQZXuyRg5TmAExzrXbJHofC2EKYfUKnbXhrw2xS-a6bLPsOY7v6vJzgbGxiqCfRz4cPH3DV9uGI7DTYJX-8qYfk9f7u5faRTp8fnm5vprSSACtqNWO1MEpiaRvJaskKjVxw5L6AMj8GsqoLLCWXTcnQmrJBBbURRnNUjTgkF2vdZezfB59WbtGm0SEG3w_JWWWNlVrITJ79Ief9EEM2N0LcMC50htgaqmKfUvSNW8Z2gfHTMXBjkm6dpMvG3JikG4VPN8JDufD1z8Z3dBk43wCYKuyaiKFq0y8ngRtpeOb4mkt5FGY-_jr8__oXaCKIjg</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Budovsky, Arie</creator><creator>Fraifeld, Vadim E.</creator><creator>Aronov, Stella</creator><general>Springer Netherlands</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Linking cell polarity, aging and rejuvenation</title><author>Budovsky, Arie ; Fraifeld, Vadim E. ; Aronov, Stella</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-8611d3754ab8f41d4196a232a2e90be90104cd9ab424fb1a87bfa50d73762a5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Cell Polarity</topic><topic>Daughters</topic><topic>Development. Metamorphosis. Moult. Ageing</topic><topic>Developmental Biology</topic><topic>Fundamental and applied biological sciences. 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While much is known about the establishment and maintenance of cell polarity, its role in aging and age-related diseases remains to be fully addressed. Nonetheless, the exciting findings in the budding yeast indicate that the polar processes are intimately linked to both aging of the mother cell and rejuvenation of the daughter cell. This includes polar segregation of damaged proteins and ERCs due to the septin-based diffusion barrier, asymmetric inheritance of MDR proteins and retrograde protein transport. The principal, still unexplored question is whether the same polar mechanisms work during the asymmetric division of germ and stem cells, allowing their rejuvenation across generations. Further strengthening the links between cell polarity and aging is a large number of common genes associated with both polarity and longevity. Given a strong similarity between mechanisms of cell polarity in yeast and higher eukaryotes, the budding yeast
Saccharomyces cerevisiae
could serve as a convenient model system for studying the links between the cell polarity, aging and rejuvenation. Consequently, exploring the potential mammalian equivalents of yeast-established polarity mechanisms could be the focus for future biogerontological investigations.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>20978937</pmid><doi>10.1007/s10522-010-9305-4</doi><tpages>9</tpages></addata></record> |
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| subjects | Aging Animals Biological and medical sciences Biomedical and Life Sciences Cell Biology Cell Polarity Daughters Development. Metamorphosis. Moult. Ageing Developmental Biology Fundamental and applied biological sciences. Psychology Geriatrics/Gerontology Humans Life Sciences Opinion Proteins Rejuvenation Ribosomal DNA Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems Yeast |
| title | Linking cell polarity, aging and rejuvenation |
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