Severe hepatotoxicity associated with the combination of spiramycin plus metronidazole
Drug-induced liver injury (DILI) is a leading cause of acute liver failure and is the most frequent reason for post-marketing drug withdrawal. The spectrum of liver injury is wide, ranging from mild and subclinical injury, noticeable only on routine biochemical testing, to fulminant liver failure an...
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| Veröffentlicht in: | Arab journal of gastroenterology 2011-03, Vol.12 (1), p.44-47 |
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| container_title | Arab journal of gastroenterology |
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| creator | Hussein, Rola El-Halabi, Mustapha Ghaith, Ola Jurdi, Nawaf Azar, Cecilio Mansour, Nabil Sharara, Ala I. |
| description | Drug-induced liver injury (DILI) is a leading cause of acute liver failure and is the most frequent reason for post-marketing drug withdrawal. The spectrum of liver injury is wide, ranging from mild and subclinical injury, noticeable only on routine biochemical testing, to fulminant liver failure and death. Antibiotics, as a group, are a leading cause of DILI. We herein describe 4 patients who developed moderate to severe hepatotoxicity after exposure to a commercially – available combination of two antibiotics – spiramycin and metronidazole – commonly used for the treatment and prevention of periodontal infections. No other aetiology for liver injury could be identified in all cases. Two patients recovered spontaneously, and two had a more severe course, one responding to corticosteroids and mycophenolate mofetil and the other requiring liver transplantation for subacute massive necrosis. |
| doi_str_mv | 10.1016/j.ajg.2010.11.001 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1687-1979 |
| ispartof | Arab journal of gastroenterology, 2011-03, Vol.12 (1), p.44-47 |
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| subjects | Adult Adverse events Anti-Bacterial Agents - adverse effects Antibiotics Antiprotozoal Agents - adverse effects Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - physiopathology Chemical and Drug Induced Liver Injury - therapy Drug Drug Combinations Humans Injury Liver Liver Transplantation Male Metronidazole - adverse effects Spiramycin - adverse effects Treatment Outcome |
| title | Severe hepatotoxicity associated with the combination of spiramycin plus metronidazole |
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