Estradiol Down-Regulates RF-Amide-Related Peptide (RFRP) Expression in the Mouse Hypothalamus

Estradiol down-regulates preproRFRP mRNA expression and a subset of RFRP neurons contains low levels of nuclear estrogen receptor α in mice. In most mammals, RF-amide-related peptides are synthesized in the dorsomedial hypothalamic nucleus and regulate reproduction via inhibiting GnRH neurons and, p...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2011-04, Vol.152 (4), p.1684-1690
Hauptverfasser:	Molnár, C. S, Kalló, I, Liposits, Z, Hrabovszky, E
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Biological and medical sciences Down-regulation Estradiol - pharmacology Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism Estrogen receptors Estrogens Feedback Fundamental and applied biological sciences. Psychology Gene expression Gonadotropin-releasing hormone Hybridization Hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism Immunohistochemistry In Situ Hybridization Mice Neuromodulation Neurons Neuropeptides - genetics Neuropeptides - metabolism Ovariectomy Peptides Pituitary (anterior) Radio frequency Receptors RNA, Messenger - genetics Sex hormones Synthesis Vertebrates: endocrinology Xenoestrogens
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