p38γ Activation Triggers Dynamical Changes in Allosteric Docking Sites

Mitogen-activated protein kinases (MAPKs) are serine-threonine kinases that participate in signal transduction pathways. p38 MAPKs have four isoforms (p38α, p38β, p38γ, and p38δ) which are involved in multiple cellular functions such as proliferation, differentiation, survival, and migration. MAPK k...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemistry (Easton) 2011-03, Vol.50 (8), p.1384-1395
Hauptverfasser:	Rodriguez Limardo, Ramiro G, Ferreiro, Dardo N, Roitberg, Adrián E, Marti, Marcelo A, Turjanski, Adrian G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Allosteric Regulation Enzyme Activation Mitogen-Activated Protein Kinase 12 - chemistry Mitogen-Activated Protein Kinase 12 - metabolism Molecular Dynamics Simulation Movement Phosphorylation Protein Structure, Secondary Protein Structure, Tertiary
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!