The adapter protein APPL1 links FSH receptor to inositol 1,4,5-trisphosphate production and is implicated in intracellular Ca(2+) mobilization

FSH binds to its receptor (FSHR) on target cells in the ovary and testis, to regulate oogenesis and spermatogenesis, respectively. The signaling cascades activated after ligand binding are extremely complex and have been shown to include protein kinase A, mitogen-activated protein kinase, phosphatid...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2011-04, Vol.152 (4), p.1691-1701
Hauptverfasser:	Thomas, Richard M, Nechamen, Cheryl A, Mazurkiewicz, Joseph E, Ulloa-Aguirre, Alfredo, Dias, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Blotting, Western Calcium - metabolism Cell Line Cyclic AMP - metabolism Estradiol - metabolism Female Follicle Stimulating Hormone - metabolism Humans Immunoprecipitation Inositol 1,4,5-Trisphosphate - biosynthesis Mutation Progesterone - metabolism Protein Binding Rats Receptors, FSH - genetics Receptors, FSH - metabolism
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