The Potential of Osteopontin as a Therapeutic Target for Human Colorectal Cancer

Objective Osteopontin (OPN), a phosphorylated glycoprotein, is involved in tumor progression and metastasis. Previously, we have reported that high OPN mRNA expression level possessed clinicopathological or prognostic significance in human colorectal cancer (CRC). The aim of this study is to investi...

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Veröffentlicht in:	Journal of gastrointestinal surgery 2011-04, Vol.15 (4), p.652-659
Hauptverfasser:	Likui, Wang, Hong, Wang, Shuwen, Zhang, Yuangang, You, Yan, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cancer therapies Cell Line, Tumor Cell Proliferation Cell Survival Chemotherapy Colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - physiopathology Colorectal Neoplasms - radiotherapy Down-Regulation Female Gastroenterology Hospitals Humans Medical prognosis Medicine Medicine & Public Health Metastasis Mice Mice, Nude Original Article Osteopontin - metabolism Osteopontin - physiology Polymerase chain reaction Proteins Radiation Radiation Tolerance RNA Interference RNA, Messenger - metabolism Surgery Tumor Stem Cell Assay
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