Facilitated acquisition of the classically conditioned eyeblink response in females is augmented in those taking oral contraceptives

▶ Females exhibit faster new motor learning than males. ▶ Oral contraceptives facilitate new motor learning. Sex differences in attentional processing and new motor learning remain controversial, and are complicated by the influence of endogenous and exogenous gonadal hormones. Facilitated acquisiti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Behavioural brain research 2011, Vol.216 (1), p.301-307
Hauptverfasser: Holloway, Jacqueline L., Beck, Kevin D., Servatius, Richard J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 307
container_issue 1
container_start_page 301
container_title Behavioural brain research
container_volume 216
creator Holloway, Jacqueline L.
Beck, Kevin D.
Servatius, Richard J.
description ▶ Females exhibit faster new motor learning than males. ▶ Oral contraceptives facilitate new motor learning. Sex differences in attentional processing and new motor learning remain controversial, and are complicated by the influence of endogenous and exogenous gonadal hormones. Facilitated acquisition of a classically conditioned eyeblink response in oral contraceptive-using women has been reported, as have menstrual cycle-dependent changes in pre-pulse inhibition (PPI). The current study sought to replicate and extend these findings by comparing acquisition of the conditioned eyeblink response and PPI in women currently taking oral contraceptives (OCs), women not taking OCs, as well as men. Women were assigned to participate either during their follicular or luteal menstrual cycle phase. Acquisition was assessed in a two-tone discrimination delay paradigm (500-ms conditional stimulus (CS); 100-ms airpuff unconditional stimulus (US)). PPI was lower in males and OC-users depending on stimulus intensity. Consistent with early classical conditioning research, females acquired an eyeblink conditioned response faster than males. Faster acquisition was associated with larger unconditional responses. Women taking OCs demonstrated accelerated conditioned response acquisition compared to women not taking OCs and males although unconditional responses were comparable to males. Facilitated acquisition of new motor learning in OC-users was replicated in a college-aged population of women and was not secondary to enhanced reactivity to sensory stimuli.
doi_str_mv 10.1016/j.bbr.2010.08.008
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_858422203</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S016643281000567X</els_id><sourcerecordid>858422203</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-ddbf790fae802b021eebc2a411834f10749f761834a05b8caccbec85db3afb183</originalsourceid><addsrcrecordid>eNqFkbFuFDEQhi0EIkfgAWiQG5RqD9vr3fWJCkUJIEWigdoae8eJL971xfZFup4Hx5s7oIPKmvE3n0bzE_KWszVnvP-wXRuT1oLVmqk1Y-oZWXE1iGbo5OY5WVWmb2Qr1Bl5lfOWMSZZx1-SM8EG0XZ9vyI_r8H64AsUHCnYh73Pvvg40-houUNqA-TsLYRwoDbO49NnRfGAJvj5nibMuzhnpH6mDicImKnPFPa3E86LtPbLXaxAgXs_39KYICyqksDirvhHzK_JCwch45vTe05-XF99v_zS3Hz7_PXy001jJZelGUfjhg1zgIoJwwRHNFaA5Fy10nE2yI0b-qUA1hllwVqDVnWjacGZ2j8nF0fvLsWHPeaiJ58thgAzxn3WqlNSCMHa_5JD3_K-k5JVkh9Jm2LOCZ3eJT9BOmjO9JKS3uqakl5S0kzpmlKdeXey782E45-J37FU4P0JgFxv7xLM1ue_XCvbXolF9PHIYb3ao8eks_U4Wxx9Qlv0GP0_1vgFEQqytQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>763165440</pqid></control><display><type>article</type><title>Facilitated acquisition of the classically conditioned eyeblink response in females is augmented in those taking oral contraceptives</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Holloway, Jacqueline L. ; Beck, Kevin D. ; Servatius, Richard J.</creator><creatorcontrib>Holloway, Jacqueline L. ; Beck, Kevin D. ; Servatius, Richard J.</creatorcontrib><description>▶ Females exhibit faster new motor learning than males. ▶ Oral contraceptives facilitate new motor learning. Sex differences in attentional processing and new motor learning remain controversial, and are complicated by the influence of endogenous and exogenous gonadal hormones. Facilitated acquisition of a classically conditioned eyeblink response in oral contraceptive-using women has been reported, as have menstrual cycle-dependent changes in pre-pulse inhibition (PPI). The current study sought to replicate and extend these findings by comparing acquisition of the conditioned eyeblink response and PPI in women currently taking oral contraceptives (OCs), women not taking OCs, as well as men. Women were assigned to participate either during their follicular or luteal menstrual cycle phase. Acquisition was assessed in a two-tone discrimination delay paradigm (500-ms conditional stimulus (CS); 100-ms airpuff unconditional stimulus (US)). PPI was lower in males and OC-users depending on stimulus intensity. Consistent with early classical conditioning research, females acquired an eyeblink conditioned response faster than males. Faster acquisition was associated with larger unconditional responses. Women taking OCs demonstrated accelerated conditioned response acquisition compared to women not taking OCs and males although unconditional responses were comparable to males. Facilitated acquisition of new motor learning in OC-users was replicated in a college-aged population of women and was not secondary to enhanced reactivity to sensory stimuli.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2010.08.008</identifier><identifier>PMID: 20723566</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Acoustic startle response ; Acoustic Stimulation ; Adolescent ; Analysis of Variance ; Association Learning - drug effects ; Association Learning - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; Conditioning, Eyelid - drug effects ; Conditioning, Eyelid - physiology ; Contraceptives, Oral, Hormonal - administration &amp; dosage ; Electromyography ; Estrogen ; Ethinyl estradiol ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Menstrual cycle ; Menstrual Cycle - physiology ; Pre-pulse inhibition ; Progesterone ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Sensory Gating - drug effects ; Sensory Gating - physiology ; Sex differences ; Sex Factors ; Young Adult</subject><ispartof>Behavioural brain research, 2011, Vol.216 (1), p.301-307</ispartof><rights>2010</rights><rights>2015 INIST-CNRS</rights><rights>Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-ddbf790fae802b021eebc2a411834f10749f761834a05b8caccbec85db3afb183</citedby><cites>FETCH-LOGICAL-c414t-ddbf790fae802b021eebc2a411834f10749f761834a05b8caccbec85db3afb183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016643281000567X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=23436828$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20723566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holloway, Jacqueline L.</creatorcontrib><creatorcontrib>Beck, Kevin D.</creatorcontrib><creatorcontrib>Servatius, Richard J.</creatorcontrib><title>Facilitated acquisition of the classically conditioned eyeblink response in females is augmented in those taking oral contraceptives</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>▶ Females exhibit faster new motor learning than males. ▶ Oral contraceptives facilitate new motor learning. Sex differences in attentional processing and new motor learning remain controversial, and are complicated by the influence of endogenous and exogenous gonadal hormones. Facilitated acquisition of a classically conditioned eyeblink response in oral contraceptive-using women has been reported, as have menstrual cycle-dependent changes in pre-pulse inhibition (PPI). The current study sought to replicate and extend these findings by comparing acquisition of the conditioned eyeblink response and PPI in women currently taking oral contraceptives (OCs), women not taking OCs, as well as men. Women were assigned to participate either during their follicular or luteal menstrual cycle phase. Acquisition was assessed in a two-tone discrimination delay paradigm (500-ms conditional stimulus (CS); 100-ms airpuff unconditional stimulus (US)). PPI was lower in males and OC-users depending on stimulus intensity. Consistent with early classical conditioning research, females acquired an eyeblink conditioned response faster than males. Faster acquisition was associated with larger unconditional responses. Women taking OCs demonstrated accelerated conditioned response acquisition compared to women not taking OCs and males although unconditional responses were comparable to males. Facilitated acquisition of new motor learning in OC-users was replicated in a college-aged population of women and was not secondary to enhanced reactivity to sensory stimuli.</description><subject>Acoustic startle response</subject><subject>Acoustic Stimulation</subject><subject>Adolescent</subject><subject>Analysis of Variance</subject><subject>Association Learning - drug effects</subject><subject>Association Learning - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Conditioning, Eyelid - drug effects</subject><subject>Conditioning, Eyelid - physiology</subject><subject>Contraceptives, Oral, Hormonal - administration &amp; dosage</subject><subject>Electromyography</subject><subject>Estrogen</subject><subject>Ethinyl estradiol</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Menstrual cycle</subject><subject>Menstrual Cycle - physiology</subject><subject>Pre-pulse inhibition</subject><subject>Progesterone</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Sensory Gating - drug effects</subject><subject>Sensory Gating - physiology</subject><subject>Sex differences</subject><subject>Sex Factors</subject><subject>Young Adult</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkbFuFDEQhi0EIkfgAWiQG5RqD9vr3fWJCkUJIEWigdoae8eJL971xfZFup4Hx5s7oIPKmvE3n0bzE_KWszVnvP-wXRuT1oLVmqk1Y-oZWXE1iGbo5OY5WVWmb2Qr1Bl5lfOWMSZZx1-SM8EG0XZ9vyI_r8H64AsUHCnYh73Pvvg40-houUNqA-TsLYRwoDbO49NnRfGAJvj5nibMuzhnpH6mDicImKnPFPa3E86LtPbLXaxAgXs_39KYICyqksDirvhHzK_JCwch45vTe05-XF99v_zS3Hz7_PXy001jJZelGUfjhg1zgIoJwwRHNFaA5Fy10nE2yI0b-qUA1hllwVqDVnWjacGZ2j8nF0fvLsWHPeaiJ58thgAzxn3WqlNSCMHa_5JD3_K-k5JVkh9Jm2LOCZ3eJT9BOmjO9JKS3uqakl5S0kzpmlKdeXey782E45-J37FU4P0JgFxv7xLM1ue_XCvbXolF9PHIYb3ao8eks_U4Wxx9Qlv0GP0_1vgFEQqytQ</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Holloway, Jacqueline L.</creator><creator>Beck, Kevin D.</creator><creator>Servatius, Richard J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>2011</creationdate><title>Facilitated acquisition of the classically conditioned eyeblink response in females is augmented in those taking oral contraceptives</title><author>Holloway, Jacqueline L. ; Beck, Kevin D. ; Servatius, Richard J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-ddbf790fae802b021eebc2a411834f10749f761834a05b8caccbec85db3afb183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acoustic startle response</topic><topic>Acoustic Stimulation</topic><topic>Adolescent</topic><topic>Analysis of Variance</topic><topic>Association Learning - drug effects</topic><topic>Association Learning - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Conditioning, Eyelid - drug effects</topic><topic>Conditioning, Eyelid - physiology</topic><topic>Contraceptives, Oral, Hormonal - administration &amp; dosage</topic><topic>Electromyography</topic><topic>Estrogen</topic><topic>Ethinyl estradiol</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Menstrual cycle</topic><topic>Menstrual Cycle - physiology</topic><topic>Pre-pulse inhibition</topic><topic>Progesterone</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Sensory Gating - drug effects</topic><topic>Sensory Gating - physiology</topic><topic>Sex differences</topic><topic>Sex Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holloway, Jacqueline L.</creatorcontrib><creatorcontrib>Beck, Kevin D.</creatorcontrib><creatorcontrib>Servatius, Richard J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holloway, Jacqueline L.</au><au>Beck, Kevin D.</au><au>Servatius, Richard J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Facilitated acquisition of the classically conditioned eyeblink response in females is augmented in those taking oral contraceptives</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2011</date><risdate>2011</risdate><volume>216</volume><issue>1</issue><spage>301</spage><epage>307</epage><pages>301-307</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>▶ Females exhibit faster new motor learning than males. ▶ Oral contraceptives facilitate new motor learning. Sex differences in attentional processing and new motor learning remain controversial, and are complicated by the influence of endogenous and exogenous gonadal hormones. Facilitated acquisition of a classically conditioned eyeblink response in oral contraceptive-using women has been reported, as have menstrual cycle-dependent changes in pre-pulse inhibition (PPI). The current study sought to replicate and extend these findings by comparing acquisition of the conditioned eyeblink response and PPI in women currently taking oral contraceptives (OCs), women not taking OCs, as well as men. Women were assigned to participate either during their follicular or luteal menstrual cycle phase. Acquisition was assessed in a two-tone discrimination delay paradigm (500-ms conditional stimulus (CS); 100-ms airpuff unconditional stimulus (US)). PPI was lower in males and OC-users depending on stimulus intensity. Consistent with early classical conditioning research, females acquired an eyeblink conditioned response faster than males. Faster acquisition was associated with larger unconditional responses. Women taking OCs demonstrated accelerated conditioned response acquisition compared to women not taking OCs and males although unconditional responses were comparable to males. Facilitated acquisition of new motor learning in OC-users was replicated in a college-aged population of women and was not secondary to enhanced reactivity to sensory stimuli.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>20723566</pmid><doi>10.1016/j.bbr.2010.08.008</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0166-4328
ispartof Behavioural brain research, 2011, Vol.216 (1), p.301-307
issn 0166-4328
1872-7549
language eng
recordid cdi_proquest_miscellaneous_858422203
source MEDLINE; Elsevier ScienceDirect Journals Complete
subjects Acoustic startle response
Acoustic Stimulation
Adolescent
Analysis of Variance
Association Learning - drug effects
Association Learning - physiology
Behavioral psychophysiology
Biological and medical sciences
Conditioning, Eyelid - drug effects
Conditioning, Eyelid - physiology
Contraceptives, Oral, Hormonal - administration & dosage
Electromyography
Estrogen
Ethinyl estradiol
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Menstrual cycle
Menstrual Cycle - physiology
Pre-pulse inhibition
Progesterone
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Sensory Gating - drug effects
Sensory Gating - physiology
Sex differences
Sex Factors
Young Adult
title Facilitated acquisition of the classically conditioned eyeblink response in females is augmented in those taking oral contraceptives
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T03%3A13%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Facilitated%20acquisition%20of%20the%20classically%20conditioned%20eyeblink%20response%20in%20females%20is%20augmented%20in%20those%20taking%20oral%20contraceptives&rft.jtitle=Behavioural%20brain%20research&rft.au=Holloway,%20Jacqueline%20L.&rft.date=2011&rft.volume=216&rft.issue=1&rft.spage=301&rft.epage=307&rft.pages=301-307&rft.issn=0166-4328&rft.eissn=1872-7549&rft.coden=BBREDI&rft_id=info:doi/10.1016/j.bbr.2010.08.008&rft_dat=%3Cproquest_cross%3E858422203%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=763165440&rft_id=info:pmid/20723566&rft_els_id=S016643281000567X&rfr_iscdi=true