Hydroxyurea suppresses HCV replication in humans: a Phase I trial of oral hydroxyurea in chronic hepatitis C patients

HCV is the main causative agent of chronic liver disease, which could progress to liver cirrhosis and hepatocellular carcinoma. By using a recently developed genome-length HCV RNA replication reporter assay system, we found that hydroxyurea (HU), an inhibitor of DNA synthesis, inhibited HCV RNA repl...

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Veröffentlicht in:	Antiviral therapy 2010-01, Vol.15 (8), p.1179-1183
Hauptverfasser:	NOZAKI, Akito, NUMATA, Kazushi, TANAKA, Katsuaki, MORIMOTO, Manabu, KONDO, Masaaki, SUGIMORI, Kazuya, MORITA, Satoshi, MIYAJIMA, Eiji, IKEDA, Masanori, KATO, Nobuyuki, MAEDA, Shin
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aged Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Cirrhosis Clinical trials DNA biosynthesis Female Hepacivirus - drug effects Hepacivirus - physiology Hepatitis C Hepatitis C virus Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology Hepatocellular carcinoma Human viral diseases Humans Hydroxyurea Hydroxyurea - administration & dosage Hydroxyurea - pharmacology Infectious diseases Japan Liver diseases Male Medical sciences Middle Aged Nucleic Acid Synthesis Inhibitors - administration & dosage Nucleic Acid Synthesis Inhibitors - pharmacology Pharmacology. Drug treatments Replication RNA RNA, Viral - biosynthesis RNA, Viral - blood Toxicity Transcription Viral diseases Viral hepatitis Virus Replication - drug effects
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