Lead pellet retention time and associated toxicity in northern bobwhite quail (Colinus virginianus)
Birds are exposed to Pb by oral ingestion of spent Pb shot as grit. A paucity of data exists for retention and clearance of these particles in the bird gastrointestinal tract. In the current study, northern bobwhite quail (Colinus virginianus) were orally gavaged with 1, 5, or 10 Pb shot pellets, of...
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| Veröffentlicht in: | Environmental toxicology and chemistry 2010-12, Vol.29 (12), p.2869-2874 |
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| creator | Kerr, Richard Holladay, Steven Jarrett, Timothy Selcer, Barbara Meldrum, Blair Williams, Susan Tannenbaum, Lawrence Holladay, Jeremy Williams, Jamie Gogal, Robert |
| description | Birds are exposed to Pb by oral ingestion of spent Pb shot as grit. A paucity of data exists for retention and clearance of these particles in the bird gastrointestinal tract. In the current study, northern bobwhite quail (Colinus virginianus) were orally gavaged with 1, 5, or 10 Pb shot pellets, of 2‐mm diameter, and radiographically followed over time. Blood Pb levels and other measures of toxicity were collected, to correlate with pellet retention. Quail dosed with either 5 or 10 pellets exhibited morbidity between weeks 1 and 2 and were removed from further study. Most of the Pb pellets were absorbed or excreted within 14 d of gavage, independent of dose. Pellet size in the ventriculus decreased over time in radiographs, suggesting dissolution caused by the acidic pH. Birds dosed with one pellet showed mean blood Pb levels that exceeded 1,300 µg/dl at week 1, further supporting dissolution in the gastrointestinal tract. Limited signs of toxicity were seen in the one‐pellet birds; however, plasma δ‐aminolevulinic acid dehydratase (d‐ALAD) activity was persistently depressed, suggesting possible impaired hematological function. Environ. Toxicol. Chem. 2010;29:2869–2874. © 2010 SETAC |
| doi_str_mv | 10.1002/etc.355 |
| format | Article |
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A paucity of data exists for retention and clearance of these particles in the bird gastrointestinal tract. In the current study, northern bobwhite quail (Colinus virginianus) were orally gavaged with 1, 5, or 10 Pb shot pellets, of 2‐mm diameter, and radiographically followed over time. Blood Pb levels and other measures of toxicity were collected, to correlate with pellet retention. Quail dosed with either 5 or 10 pellets exhibited morbidity between weeks 1 and 2 and were removed from further study. Most of the Pb pellets were absorbed or excreted within 14 d of gavage, independent of dose. Pellet size in the ventriculus decreased over time in radiographs, suggesting dissolution caused by the acidic pH. Birds dosed with one pellet showed mean blood Pb levels that exceeded 1,300 µg/dl at week 1, further supporting dissolution in the gastrointestinal tract. Limited signs of toxicity were seen in the one‐pellet birds; however, plasma δ‐aminolevulinic acid dehydratase (d‐ALAD) activity was persistently depressed, suggesting possible impaired hematological function. Environ. Toxicol. Chem. 2010;29:2869–2874. © 2010 SETAC</description><identifier>ISSN: 0730-7268</identifier><identifier>ISSN: 1552-8618</identifier><identifier>EISSN: 1552-8618</identifier><identifier>DOI: 10.1002/etc.355</identifier><identifier>PMID: 20836061</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Acidity ; Animals ; Avian ; Birds ; Blood ; Colinus - blood ; Colinus - metabolism ; Colinus virginianus ; d-ALAD ; Dissolution ; Female ; Gastrointestinal tract ; Ingestion ; Lead ; Lead (metal) ; Lead - blood ; Lead - pharmacokinetics ; Lead - toxicity ; Male ; Pellets ; Radiographs ; Random Allocation ; Retention ; Retention time ; Shot ; Toxicity ; Toxicology ; Ventriculus</subject><ispartof>Environmental toxicology and chemistry, 2010-12, Vol.29 (12), p.2869-2874</ispartof><rights>Copyright © 2010 SETAC</rights><rights>2010 SETAC.</rights><rights>Copyright Blackwell Publishing Ltd. Dec 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4795-604ba68b0cc06d28eeae93eeaaab2eac030eefe1efd8f14dd146fae66072282a3</citedby><cites>FETCH-LOGICAL-c4795-604ba68b0cc06d28eeae93eeaaab2eac030eefe1efd8f14dd146fae66072282a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fetc.355$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fetc.355$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20836061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kerr, Richard</creatorcontrib><creatorcontrib>Holladay, Steven</creatorcontrib><creatorcontrib>Jarrett, Timothy</creatorcontrib><creatorcontrib>Selcer, Barbara</creatorcontrib><creatorcontrib>Meldrum, Blair</creatorcontrib><creatorcontrib>Williams, Susan</creatorcontrib><creatorcontrib>Tannenbaum, Lawrence</creatorcontrib><creatorcontrib>Holladay, Jeremy</creatorcontrib><creatorcontrib>Williams, Jamie</creatorcontrib><creatorcontrib>Gogal, Robert</creatorcontrib><title>Lead pellet retention time and associated toxicity in northern bobwhite quail (Colinus virginianus)</title><title>Environmental toxicology and chemistry</title><addtitle>Environmental Toxicology and Chemistry</addtitle><description>Birds are exposed to Pb by oral ingestion of spent Pb shot as grit. A paucity of data exists for retention and clearance of these particles in the bird gastrointestinal tract. In the current study, northern bobwhite quail (Colinus virginianus) were orally gavaged with 1, 5, or 10 Pb shot pellets, of 2‐mm diameter, and radiographically followed over time. Blood Pb levels and other measures of toxicity were collected, to correlate with pellet retention. Quail dosed with either 5 or 10 pellets exhibited morbidity between weeks 1 and 2 and were removed from further study. Most of the Pb pellets were absorbed or excreted within 14 d of gavage, independent of dose. Pellet size in the ventriculus decreased over time in radiographs, suggesting dissolution caused by the acidic pH. Birds dosed with one pellet showed mean blood Pb levels that exceeded 1,300 µg/dl at week 1, further supporting dissolution in the gastrointestinal tract. Limited signs of toxicity were seen in the one‐pellet birds; however, plasma δ‐aminolevulinic acid dehydratase (d‐ALAD) activity was persistently depressed, suggesting possible impaired hematological function. Environ. Toxicol. Chem. 2010;29:2869–2874. © 2010 SETAC</description><subject>Acidity</subject><subject>Animals</subject><subject>Avian</subject><subject>Birds</subject><subject>Blood</subject><subject>Colinus - blood</subject><subject>Colinus - metabolism</subject><subject>Colinus virginianus</subject><subject>d-ALAD</subject><subject>Dissolution</subject><subject>Female</subject><subject>Gastrointestinal tract</subject><subject>Ingestion</subject><subject>Lead</subject><subject>Lead (metal)</subject><subject>Lead - blood</subject><subject>Lead - pharmacokinetics</subject><subject>Lead - toxicity</subject><subject>Male</subject><subject>Pellets</subject><subject>Radiographs</subject><subject>Random Allocation</subject><subject>Retention</subject><subject>Retention time</subject><subject>Shot</subject><subject>Toxicity</subject><subject>Toxicology</subject><subject>Ventriculus</subject><issn>0730-7268</issn><issn>1552-8618</issn><issn>1552-8618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90UFrFDEUB_Agit1W8RtI8GJFpr4kM5nMURbbCoNelHoLmcwbmzqbbJOM7X57U7ZWEPSS5PDjH977E_KCwQkD4O8w2xPRNI_IijUNr5Rk6jFZQSugarlUB-QwpSsAJruue0oOOCghQbIVsT2akW5xnjHTiBl9dsHT7DZIjR-pSSlYZzKONIdbZ13eUeepDzFfYvR0CMPNpctIrxfjZnq8DrPzS6I_XfzuvDPl_eYZeTKZOeHz-_uIfD398GV9XvWfzz6u3_eVrduuqSTUg5FqAGtBjlwhGuxEOY0ZOBoLAhAnZDiNamL1OLJaTgalhJZzxY04Iq_3udsYrhdMWW9csmU04zEsSatG1Zy1NRR5_F_JZMvk3bJYoa_-oldhib7MoZVUCsom2z8_2xhSijjpbXQbE3eagb4rSJeCdCmoyJf3ccuwwfHB_W6kgLd7cONm3P0rRxeyj6v22qWMtw_axB9atqJt9MWnM30u-guhvvWai19RN6lm</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Kerr, Richard</creator><creator>Holladay, Steven</creator><creator>Jarrett, Timothy</creator><creator>Selcer, Barbara</creator><creator>Meldrum, Blair</creator><creator>Williams, Susan</creator><creator>Tannenbaum, Lawrence</creator><creator>Holladay, Jeremy</creator><creator>Williams, Jamie</creator><creator>Gogal, Robert</creator><general>John Wiley & Sons, Inc</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7SU</scope><scope>KR7</scope><scope>7U1</scope><scope>7U2</scope></search><sort><creationdate>201012</creationdate><title>Lead pellet retention time and associated toxicity in northern bobwhite quail (Colinus virginianus)</title><author>Kerr, Richard ; Holladay, Steven ; Jarrett, Timothy ; Selcer, Barbara ; Meldrum, Blair ; Williams, Susan ; Tannenbaum, Lawrence ; Holladay, Jeremy ; Williams, Jamie ; Gogal, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4795-604ba68b0cc06d28eeae93eeaaab2eac030eefe1efd8f14dd146fae66072282a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acidity</topic><topic>Animals</topic><topic>Avian</topic><topic>Birds</topic><topic>Blood</topic><topic>Colinus - blood</topic><topic>Colinus - metabolism</topic><topic>Colinus virginianus</topic><topic>d-ALAD</topic><topic>Dissolution</topic><topic>Female</topic><topic>Gastrointestinal tract</topic><topic>Ingestion</topic><topic>Lead</topic><topic>Lead (metal)</topic><topic>Lead - blood</topic><topic>Lead - pharmacokinetics</topic><topic>Lead - toxicity</topic><topic>Male</topic><topic>Pellets</topic><topic>Radiographs</topic><topic>Random Allocation</topic><topic>Retention</topic><topic>Retention time</topic><topic>Shot</topic><topic>Toxicity</topic><topic>Toxicology</topic><topic>Ventriculus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kerr, Richard</creatorcontrib><creatorcontrib>Holladay, Steven</creatorcontrib><creatorcontrib>Jarrett, Timothy</creatorcontrib><creatorcontrib>Selcer, Barbara</creatorcontrib><creatorcontrib>Meldrum, Blair</creatorcontrib><creatorcontrib>Williams, Susan</creatorcontrib><creatorcontrib>Tannenbaum, Lawrence</creatorcontrib><creatorcontrib>Holladay, Jeremy</creatorcontrib><creatorcontrib>Williams, Jamie</creatorcontrib><creatorcontrib>Gogal, Robert</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>Environmental Engineering Abstracts</collection><collection>Civil Engineering Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><jtitle>Environmental toxicology and chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kerr, Richard</au><au>Holladay, Steven</au><au>Jarrett, Timothy</au><au>Selcer, Barbara</au><au>Meldrum, Blair</au><au>Williams, Susan</au><au>Tannenbaum, Lawrence</au><au>Holladay, Jeremy</au><au>Williams, Jamie</au><au>Gogal, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lead pellet retention time and associated toxicity in northern bobwhite quail (Colinus virginianus)</atitle><jtitle>Environmental toxicology and chemistry</jtitle><addtitle>Environmental Toxicology and Chemistry</addtitle><date>2010-12</date><risdate>2010</risdate><volume>29</volume><issue>12</issue><spage>2869</spage><epage>2874</epage><pages>2869-2874</pages><issn>0730-7268</issn><issn>1552-8618</issn><eissn>1552-8618</eissn><abstract>Birds are exposed to Pb by oral ingestion of spent Pb shot as grit. A paucity of data exists for retention and clearance of these particles in the bird gastrointestinal tract. In the current study, northern bobwhite quail (Colinus virginianus) were orally gavaged with 1, 5, or 10 Pb shot pellets, of 2‐mm diameter, and radiographically followed over time. Blood Pb levels and other measures of toxicity were collected, to correlate with pellet retention. Quail dosed with either 5 or 10 pellets exhibited morbidity between weeks 1 and 2 and were removed from further study. Most of the Pb pellets were absorbed or excreted within 14 d of gavage, independent of dose. Pellet size in the ventriculus decreased over time in radiographs, suggesting dissolution caused by the acidic pH. Birds dosed with one pellet showed mean blood Pb levels that exceeded 1,300 µg/dl at week 1, further supporting dissolution in the gastrointestinal tract. Limited signs of toxicity were seen in the one‐pellet birds; however, plasma δ‐aminolevulinic acid dehydratase (d‐ALAD) activity was persistently depressed, suggesting possible impaired hematological function. Environ. Toxicol. Chem. 2010;29:2869–2874. © 2010 SETAC</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>20836061</pmid><doi>10.1002/etc.355</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environmental toxicology and chemistry, 2010-12, Vol.29 (12), p.2869-2874 |
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| subjects | Acidity Animals Avian Birds Blood Colinus - blood Colinus - metabolism Colinus virginianus d-ALAD Dissolution Female Gastrointestinal tract Ingestion Lead Lead (metal) Lead - blood Lead - pharmacokinetics Lead - toxicity Male Pellets Radiographs Random Allocation Retention Retention time Shot Toxicity Toxicology Ventriculus |
| title | Lead pellet retention time and associated toxicity in northern bobwhite quail (Colinus virginianus) |
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