Clavulanic acid biosynthesis and genetic manipulation for its overproduction

Clavulanic acid, a β-lactamase inhibitor, is used together with β-lactam antibiotics to create drug mixtures possessing potent antimicrobial activity. In view of the clinical and industrial importance of clavulanic acid, identification of the clavulanic acid biosynthetic pathway and the associated g...

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Veröffentlicht in:	Applied microbiology and biotechnology 2010-10, Vol.88 (3), p.659-669
Hauptverfasser:	Song, Ju Yeon, Jensen, Susan E, Lee, Kye Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Analysis Anti-Bacterial Agents - biosynthesis Antibiotics beta-Lactamases - biosynthesis beta-Lactamases - genetics Biological and medical sciences Biomedical and Life Sciences Biosynthesis Biotechnology Clavam clavulanic acid Clavulanic Acid - biosynthesis Clavulanic Acids - biosynthesis Enzymes Fundamental and applied biological sciences. Psychology Genes, Bacterial Genetic engineering Genetic Engineering - methods Life Sciences Metabolites Microbial Genetics and Genomics Microbiology Mini-Review Molecular Structure Multigene Family Pathogens Penicillin Pharmaceuticals Streptomyces - genetics Streptomyces - metabolism Streptomyces clavuligerus β-lactam antibiotics
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