Clavulanic acid biosynthesis and genetic manipulation for its overproduction
Clavulanic acid, a β-lactamase inhibitor, is used together with β-lactam antibiotics to create drug mixtures possessing potent antimicrobial activity. In view of the clinical and industrial importance of clavulanic acid, identification of the clavulanic acid biosynthetic pathway and the associated g...
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| Veröffentlicht in: | Applied microbiology and biotechnology 2010-10, Vol.88 (3), p.659-669 |
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| creator | Song, Ju Yeon Jensen, Susan E Lee, Kye Joon |
| description | Clavulanic acid, a β-lactamase inhibitor, is used together with β-lactam antibiotics to create drug mixtures possessing potent antimicrobial activity. In view of the clinical and industrial importance of clavulanic acid, identification of the clavulanic acid biosynthetic pathway and the associated gene cluster(s) in the main producer species, Streptomyces clavuligerus, has been an intriguing research question. Clavulanic acid biosynthesis was revealed to involve an interesting mechanism common to all of the clavam metabolites produced by the organism, but different from that of other β-lactam compounds. Gene clusters involved in clavulanic acid biosynthesis in S. clavuligerus occupy large regions of nucleotide sequence in three loci of its genome. In this review, clavulanic acid biosynthesis and the associated gene clusters are discussed, and clavulanic acid improvement through genetic manipulation is explained. |
| doi_str_mv | 10.1007/s00253-010-2801-2 |
| format | Article |
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In view of the clinical and industrial importance of clavulanic acid, identification of the clavulanic acid biosynthetic pathway and the associated gene cluster(s) in the main producer species, Streptomyces clavuligerus, has been an intriguing research question. Clavulanic acid biosynthesis was revealed to involve an interesting mechanism common to all of the clavam metabolites produced by the organism, but different from that of other β-lactam compounds. Gene clusters involved in clavulanic acid biosynthesis in S. clavuligerus occupy large regions of nucleotide sequence in three loci of its genome. In this review, clavulanic acid biosynthesis and the associated gene clusters are discussed, and clavulanic acid improvement through genetic manipulation is explained.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-010-2801-2</identifier><identifier>PMID: 20711575</identifier><identifier>CODEN: AMBIDG</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Acids ; Analysis ; Anti-Bacterial Agents - biosynthesis ; Antibiotics ; beta-Lactamases - biosynthesis ; beta-Lactamases - genetics ; Biological and medical sciences ; Biomedical and Life Sciences ; Biosynthesis ; Biotechnology ; Clavam ; clavulanic acid ; Clavulanic Acid - biosynthesis ; Clavulanic Acids - biosynthesis ; Enzymes ; Fundamental and applied biological sciences. Psychology ; Genes, Bacterial ; Genetic engineering ; Genetic Engineering - methods ; Life Sciences ; Metabolites ; Microbial Genetics and Genomics ; Microbiology ; Mini-Review ; Molecular Structure ; Multigene Family ; Pathogens ; Penicillin ; Pharmaceuticals ; Streptomyces - genetics ; Streptomyces - metabolism ; Streptomyces clavuligerus ; β-lactam antibiotics</subject><ispartof>Applied microbiology and biotechnology, 2010-10, Vol.88 (3), p.659-669</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-5aeb9cac486c1f0ea8f5494a601affaad8b3902d0ac8c76c49db6214eb1cc8f83</citedby><cites>FETCH-LOGICAL-c522t-5aeb9cac486c1f0ea8f5494a601affaad8b3902d0ac8c76c49db6214eb1cc8f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00253-010-2801-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00253-010-2801-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23265707$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20711575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Ju Yeon</creatorcontrib><creatorcontrib>Jensen, Susan E</creatorcontrib><creatorcontrib>Lee, Kye Joon</creatorcontrib><title>Clavulanic acid biosynthesis and genetic manipulation for its overproduction</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>Clavulanic acid, a β-lactamase inhibitor, is used together with β-lactam antibiotics to create drug mixtures possessing potent antimicrobial activity. In view of the clinical and industrial importance of clavulanic acid, identification of the clavulanic acid biosynthetic pathway and the associated gene cluster(s) in the main producer species, Streptomyces clavuligerus, has been an intriguing research question. Clavulanic acid biosynthesis was revealed to involve an interesting mechanism common to all of the clavam metabolites produced by the organism, but different from that of other β-lactam compounds. Gene clusters involved in clavulanic acid biosynthesis in S. clavuligerus occupy large regions of nucleotide sequence in three loci of its genome. In this review, clavulanic acid biosynthesis and the associated gene clusters are discussed, and clavulanic acid improvement through genetic manipulation is explained.</description><subject>Acids</subject><subject>Analysis</subject><subject>Anti-Bacterial Agents - biosynthesis</subject><subject>Antibiotics</subject><subject>beta-Lactamases - biosynthesis</subject><subject>beta-Lactamases - genetics</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biosynthesis</subject><subject>Biotechnology</subject><subject>Clavam</subject><subject>clavulanic acid</subject><subject>Clavulanic Acid - biosynthesis</subject><subject>Clavulanic Acids - biosynthesis</subject><subject>Enzymes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Bacterial</subject><subject>Genetic engineering</subject><subject>Genetic Engineering - methods</subject><subject>Life Sciences</subject><subject>Metabolites</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Mini-Review</subject><subject>Molecular Structure</subject><subject>Multigene Family</subject><subject>Pathogens</subject><subject>Penicillin</subject><subject>Pharmaceuticals</subject><subject>Streptomyces - genetics</subject><subject>Streptomyces - metabolism</subject><subject>Streptomyces clavuligerus</subject><subject>β-lactam antibiotics</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU-LFDEQxYMo7uzqB_CijSCeWqvSSSd9lEFXYcCD7jlUp5MxS09nTLoX9tuboUcXPOgpkPq9V38eYy8Q3iGAep8BuGxqQKi5Bqz5I7ZB0fAaWhSP2QZQyVrJTl-wy5xvAZDrtn3KLjgoRKnkhu22I90tI03BVmTDUPUh5vtp_uFyyBVNQ7V3k5tL9VCYYyHnEKfKx1SFOVfxzqVjisNiT9_P2BNPY3bPz-8Vu_n08fv2c737ev1l-2FXW8n5XEtyfWfJCt1a9OBIeyk6QS0geU806L7pgA9AVlvVWtENfctRuB6t1V43V-zt6lta_1xcns0hZOvGsoaLSzZaasEBNfyXVFIWDLuT5-u_yNu4pKmsUSCUXDSiKxCukE0x5-S8OaZwoHRvEMwpErNGYkok5hSJ4UXz8my89Ac3_FH8zqAAb84AZUujTzTZkB-4hrdSgSocX7lcStPepYcJ_9X91SryFA3tUzG--VZu05Tz6E5z1fwCGkWs-g</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Song, Ju Yeon</creator><creator>Jensen, Susan E</creator><creator>Lee, Kye Joon</creator><general>Berlin/Heidelberg : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20101001</creationdate><title>Clavulanic acid biosynthesis and genetic manipulation for its overproduction</title><author>Song, Ju Yeon ; Jensen, Susan E ; Lee, Kye Joon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-5aeb9cac486c1f0ea8f5494a601affaad8b3902d0ac8c76c49db6214eb1cc8f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acids</topic><topic>Analysis</topic><topic>Anti-Bacterial Agents - biosynthesis</topic><topic>Antibiotics</topic><topic>beta-Lactamases - biosynthesis</topic><topic>beta-Lactamases - genetics</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biosynthesis</topic><topic>Biotechnology</topic><topic>Clavam</topic><topic>clavulanic acid</topic><topic>Clavulanic Acid - biosynthesis</topic><topic>Clavulanic Acids - biosynthesis</topic><topic>Enzymes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Bacterial</topic><topic>Genetic engineering</topic><topic>Genetic Engineering - methods</topic><topic>Life Sciences</topic><topic>Metabolites</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbiology</topic><topic>Mini-Review</topic><topic>Molecular Structure</topic><topic>Multigene Family</topic><topic>Pathogens</topic><topic>Penicillin</topic><topic>Pharmaceuticals</topic><topic>Streptomyces - genetics</topic><topic>Streptomyces - metabolism</topic><topic>Streptomyces clavuligerus</topic><topic>β-lactam antibiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Ju Yeon</creatorcontrib><creatorcontrib>Jensen, Susan E</creatorcontrib><creatorcontrib>Lee, Kye Joon</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Access via ABI/INFORM (ProQuest)</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ProQuest Biological Science Collection</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Applied microbiology and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Ju Yeon</au><au>Jensen, Susan E</au><au>Lee, Kye Joon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clavulanic acid biosynthesis and genetic manipulation for its overproduction</atitle><jtitle>Applied microbiology and biotechnology</jtitle><stitle>Appl Microbiol Biotechnol</stitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>88</volume><issue>3</issue><spage>659</spage><epage>669</epage><pages>659-669</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><coden>AMBIDG</coden><abstract>Clavulanic acid, a β-lactamase inhibitor, is used together with β-lactam antibiotics to create drug mixtures possessing potent antimicrobial activity. In view of the clinical and industrial importance of clavulanic acid, identification of the clavulanic acid biosynthetic pathway and the associated gene cluster(s) in the main producer species, Streptomyces clavuligerus, has been an intriguing research question. Clavulanic acid biosynthesis was revealed to involve an interesting mechanism common to all of the clavam metabolites produced by the organism, but different from that of other β-lactam compounds. Gene clusters involved in clavulanic acid biosynthesis in S. clavuligerus occupy large regions of nucleotide sequence in three loci of its genome. In this review, clavulanic acid biosynthesis and the associated gene clusters are discussed, and clavulanic acid improvement through genetic manipulation is explained.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>20711575</pmid><doi>10.1007/s00253-010-2801-2</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0175-7598 |
| ispartof | Applied microbiology and biotechnology, 2010-10, Vol.88 (3), p.659-669 |
| issn | 0175-7598 1432-0614 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Acids Analysis Anti-Bacterial Agents - biosynthesis Antibiotics beta-Lactamases - biosynthesis beta-Lactamases - genetics Biological and medical sciences Biomedical and Life Sciences Biosynthesis Biotechnology Clavam clavulanic acid Clavulanic Acid - biosynthesis Clavulanic Acids - biosynthesis Enzymes Fundamental and applied biological sciences. Psychology Genes, Bacterial Genetic engineering Genetic Engineering - methods Life Sciences Metabolites Microbial Genetics and Genomics Microbiology Mini-Review Molecular Structure Multigene Family Pathogens Penicillin Pharmaceuticals Streptomyces - genetics Streptomyces - metabolism Streptomyces clavuligerus β-lactam antibiotics |
| title | Clavulanic acid biosynthesis and genetic manipulation for its overproduction |
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