Treatment with a melanocortin agonist improves abnormal lipid metabolism in streptozotocin-induced diabetic mice

Abstract Impairments in leptin–melanocortin signaling are associated with insulin-deficient diabetes and leptin treatment has been shown to be effective in reversing hyperglycemia in animal models of type 1 diabetes. Therefore, we hypothesized that enhanced central melanocortin signaling reverses th...

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Veröffentlicht in:	Neuropeptides (Edinburgh) 2011-04, Vol.45 (2), p.123-129
Hauptverfasser:	Leckstrom, Arnold, Lew, Pei San, Poritsanos, Nicole J, Mizuno, Tooru M
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science alpha-MSH - analogs & derivatives alpha-MSH - pharmacology Animals Biological and medical sciences Blood Glucose - metabolism Body Weight Central nervous system Child Diabetes Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Eating Endocrine pancreas. Apud cells (diseases) Endocrinology & Metabolism Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance FFA Fundamental and applied biological sciences. Psychology Humans Insulin Insulin - blood Leptin - blood Lipid Metabolism - drug effects Lipolysis Male Medical sciences Melanocortin Melanocortins - agonists Mice Mice, Inbred C57BL Triglycerides - blood Vertebrates: endocrinology
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