Serum vaspin levels in normal pregnancy in comparison with non-pregnant women
ObjectivePregnancy represents a state of insulin resistance (IR). Vaspin (SERPINA12) is a novel insulin-sensitizing adipokine that might be implicated in endogenous glucose regulation. However, its role in pregnancy and its circulating levels have not been adequately studied. We aimed to evaluate se...
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| Veröffentlicht in: | European journal of endocrinology 2011-04, Vol.164 (4), p.579-583 |
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| container_title | European journal of endocrinology |
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| creator | Giomisi, Athina Kourtis, Anargyros Toulis, Konstantinos A Anastasilakis, Athanasios D Makedou, Kali G Mouzaki, Maria Gerou, Spyridon Gavana, Elpida Agorastos, Theodoros Giannoulis, Charalambos |
| description | ObjectivePregnancy represents a state of insulin resistance (IR). Vaspin (SERPINA12) is a novel insulin-sensitizing adipokine that might be implicated in endogenous glucose regulation. However, its role in pregnancy and its circulating levels have not been adequately studied. We aimed to evaluate serum vaspin levels in pregnancy and their correlation with known markers of IR.DesignA group of 106 women (age 27.9±0.4 years) at the 24–30th week of gestation (pregnancy group) and another 106 age-matched healthy non-pregnant controls (control group) were included in the study.MethodsSerum glucose, insulin, vaspin, adiponectin, and lipid parameters were measured. The quantitative insulin sensitivity check index (QUICKI) was used as an insulin sensitivity index.ResultsPregnant women had significantly higher body mass index (BMI), lipids, and serum insulin and lower serum glucose and vaspin levels than controls. Vaspin was positively correlated to adiponectin in both groups (P |
| doi_str_mv | 10.1530/EJE-10-1020 |
| format | Article |
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Vaspin (SERPINA12) is a novel insulin-sensitizing adipokine that might be implicated in endogenous glucose regulation. However, its role in pregnancy and its circulating levels have not been adequately studied. We aimed to evaluate serum vaspin levels in pregnancy and their correlation with known markers of IR.DesignA group of 106 women (age 27.9±0.4 years) at the 24–30th week of gestation (pregnancy group) and another 106 age-matched healthy non-pregnant controls (control group) were included in the study.MethodsSerum glucose, insulin, vaspin, adiponectin, and lipid parameters were measured. The quantitative insulin sensitivity check index (QUICKI) was used as an insulin sensitivity index.ResultsPregnant women had significantly higher body mass index (BMI), lipids, and serum insulin and lower serum glucose and vaspin levels than controls. Vaspin was positively correlated to adiponectin in both groups (P<0.001 and P<0.004 respectively) but was not correlated to BMI, serum insulin levels, or the QUICKI index in either group. Furthermore, vaspin was negatively correlated to lipid parameters (total cholesterol, triglycerides, and low-density lipoproteins) in the pregnant but not in the non-pregnant women.ConclusionsVaspin cannot serve as a marker of IR in either pregnant or non-pregnant women, although it is significantly correlated with adiponectin. On the other hand, vaspin might be useful as a surrogate marker of lipid metabolism in pregnancy if confirmed by subsequent studies.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/EJE-10-1020</identifier><identifier>PMID: 21282352</identifier><language>eng</language><publisher>Bristol: BioScientifica</publisher><subject>Adiponectin - blood ; Adult ; Biological and medical sciences ; Blood Glucose - metabolism ; Clinical Study ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Insulin - blood ; Insulin Resistance - physiology ; Lipoproteins, HDL - blood ; Lipoproteins, LDL - blood ; Medical sciences ; Pregnancy ; Serpins - blood ; Vertebrates: endocrinology</subject><ispartof>European journal of endocrinology, 2011-04, Vol.164 (4), p.579-583</ispartof><rights>2011 European Society of Endocrinology</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b440t-6dfd3abf1d90f9b9fb2911ec9298ed9cdc435b6c00ef7c315a03b126687a86803</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24070641$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21282352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giomisi, Athina</creatorcontrib><creatorcontrib>Kourtis, Anargyros</creatorcontrib><creatorcontrib>Toulis, Konstantinos A</creatorcontrib><creatorcontrib>Anastasilakis, Athanasios D</creatorcontrib><creatorcontrib>Makedou, Kali G</creatorcontrib><creatorcontrib>Mouzaki, Maria</creatorcontrib><creatorcontrib>Gerou, Spyridon</creatorcontrib><creatorcontrib>Gavana, Elpida</creatorcontrib><creatorcontrib>Agorastos, Theodoros</creatorcontrib><creatorcontrib>Giannoulis, Charalambos</creatorcontrib><title>Serum vaspin levels in normal pregnancy in comparison with non-pregnant women</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>ObjectivePregnancy represents a state of insulin resistance (IR). Vaspin (SERPINA12) is a novel insulin-sensitizing adipokine that might be implicated in endogenous glucose regulation. However, its role in pregnancy and its circulating levels have not been adequately studied. We aimed to evaluate serum vaspin levels in pregnancy and their correlation with known markers of IR.DesignA group of 106 women (age 27.9±0.4 years) at the 24–30th week of gestation (pregnancy group) and another 106 age-matched healthy non-pregnant controls (control group) were included in the study.MethodsSerum glucose, insulin, vaspin, adiponectin, and lipid parameters were measured. The quantitative insulin sensitivity check index (QUICKI) was used as an insulin sensitivity index.ResultsPregnant women had significantly higher body mass index (BMI), lipids, and serum insulin and lower serum glucose and vaspin levels than controls. Vaspin was positively correlated to adiponectin in both groups (P<0.001 and P<0.004 respectively) but was not correlated to BMI, serum insulin levels, or the QUICKI index in either group. Furthermore, vaspin was negatively correlated to lipid parameters (total cholesterol, triglycerides, and low-density lipoproteins) in the pregnant but not in the non-pregnant women.ConclusionsVaspin cannot serve as a marker of IR in either pregnant or non-pregnant women, although it is significantly correlated with adiponectin. On the other hand, vaspin might be useful as a surrogate marker of lipid metabolism in pregnancy if confirmed by subsequent studies.</description><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Clinical Study</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin Resistance - physiology</subject><subject>Lipoproteins, HDL - blood</subject><subject>Lipoproteins, LDL - blood</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Serpins - blood</subject><subject>Vertebrates: endocrinology</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90c9LwzAUB_AgipvTk3fpRTxI9eVHu_QoY_5C8aCCt5KmyRZp05p0G_vvzdym4kEI5BE-7yV8g9AxhgucULgc349jDGER2EF9zIZZnHL6tov6wIHFLGW0hw68fwfAoYZ91COYcEIT0kePz8rN6mgufGtsVKm5qnwUKtu4WlRR69TECiuXqzPZ1K1wxjc2WphuGoyNN6CLFk2t7CHa06Ly6mizD9Dr9fhldBs_PN3cja4e4oIx6OK01CUVhcZlBjorMl2QDGMlM5JxVWaylIwmRSoBlB5KihMBtMAkTflQ8JQDHaCz9dzWNR8z5bu8Nl6qqhJWNTOf84QzzMO0IM_XUrrGe6d03jpTC7fMMeSr-PIQ31cd4gv6ZDN3VtSq_LbbvAI43QDhpai0C9kY_-MYDCFlODiydlMzmS6MU3lhGi-Nsp3RRorft28_LzThddMf-9-LPwGP8pf_</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Giomisi, Athina</creator><creator>Kourtis, Anargyros</creator><creator>Toulis, Konstantinos A</creator><creator>Anastasilakis, Athanasios D</creator><creator>Makedou, Kali G</creator><creator>Mouzaki, Maria</creator><creator>Gerou, Spyridon</creator><creator>Gavana, Elpida</creator><creator>Agorastos, Theodoros</creator><creator>Giannoulis, Charalambos</creator><general>BioScientifica</general><general>European Society of Endocrinology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Serum vaspin levels in normal pregnancy in comparison with non-pregnant women</title><author>Giomisi, Athina ; Kourtis, Anargyros ; Toulis, Konstantinos A ; Anastasilakis, Athanasios D ; Makedou, Kali G ; Mouzaki, Maria ; Gerou, Spyridon ; Gavana, Elpida ; Agorastos, Theodoros ; Giannoulis, Charalambos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b440t-6dfd3abf1d90f9b9fb2911ec9298ed9cdc435b6c00ef7c315a03b126687a86803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adiponectin - blood</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Clinical Study</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin Resistance - physiology</topic><topic>Lipoproteins, HDL - blood</topic><topic>Lipoproteins, LDL - blood</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Serpins - blood</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giomisi, Athina</creatorcontrib><creatorcontrib>Kourtis, Anargyros</creatorcontrib><creatorcontrib>Toulis, Konstantinos A</creatorcontrib><creatorcontrib>Anastasilakis, Athanasios D</creatorcontrib><creatorcontrib>Makedou, Kali G</creatorcontrib><creatorcontrib>Mouzaki, Maria</creatorcontrib><creatorcontrib>Gerou, Spyridon</creatorcontrib><creatorcontrib>Gavana, Elpida</creatorcontrib><creatorcontrib>Agorastos, Theodoros</creatorcontrib><creatorcontrib>Giannoulis, Charalambos</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giomisi, Athina</au><au>Kourtis, Anargyros</au><au>Toulis, Konstantinos A</au><au>Anastasilakis, Athanasios D</au><au>Makedou, Kali G</au><au>Mouzaki, Maria</au><au>Gerou, Spyridon</au><au>Gavana, Elpida</au><au>Agorastos, Theodoros</au><au>Giannoulis, Charalambos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum vaspin levels in normal pregnancy in comparison with non-pregnant women</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>164</volume><issue>4</issue><spage>579</spage><epage>583</epage><pages>579-583</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>ObjectivePregnancy represents a state of insulin resistance (IR). Vaspin (SERPINA12) is a novel insulin-sensitizing adipokine that might be implicated in endogenous glucose regulation. However, its role in pregnancy and its circulating levels have not been adequately studied. We aimed to evaluate serum vaspin levels in pregnancy and their correlation with known markers of IR.DesignA group of 106 women (age 27.9±0.4 years) at the 24–30th week of gestation (pregnancy group) and another 106 age-matched healthy non-pregnant controls (control group) were included in the study.MethodsSerum glucose, insulin, vaspin, adiponectin, and lipid parameters were measured. The quantitative insulin sensitivity check index (QUICKI) was used as an insulin sensitivity index.ResultsPregnant women had significantly higher body mass index (BMI), lipids, and serum insulin and lower serum glucose and vaspin levels than controls. Vaspin was positively correlated to adiponectin in both groups (P<0.001 and P<0.004 respectively) but was not correlated to BMI, serum insulin levels, or the QUICKI index in either group. Furthermore, vaspin was negatively correlated to lipid parameters (total cholesterol, triglycerides, and low-density lipoproteins) in the pregnant but not in the non-pregnant women.ConclusionsVaspin cannot serve as a marker of IR in either pregnant or non-pregnant women, although it is significantly correlated with adiponectin. On the other hand, vaspin might be useful as a surrogate marker of lipid metabolism in pregnancy if confirmed by subsequent studies.</abstract><cop>Bristol</cop><pub>BioScientifica</pub><pmid>21282352</pmid><doi>10.1530/EJE-10-1020</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of endocrinology, 2011-04, Vol.164 (4), p.579-583 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adiponectin - blood Adult Biological and medical sciences Blood Glucose - metabolism Clinical Study Endocrinopathies Female Fundamental and applied biological sciences. Psychology Humans Insulin - blood Insulin Resistance - physiology Lipoproteins, HDL - blood Lipoproteins, LDL - blood Medical sciences Pregnancy Serpins - blood Vertebrates: endocrinology |
| title | Serum vaspin levels in normal pregnancy in comparison with non-pregnant women |
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