Inhibition of Tissue Transglutaminase 2 Attenuates Contractility of Pregnant Human Myometrium

Premature delivery remains a serious risk factor in pregnancy, with currently licensed tocolytics unable to offer significant improvement in neonatal outcome. Further understanding of the regulators of uterine contractility is required to enable the development of novel and more effective tocolytic...

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Veröffentlicht in:	Biology of reproduction 2011-04, Vol.84 (4), p.646-653
Hauptverfasser:	ALCOCK, Joelle, WARREN, Averil Y, GOODSON, Yvonne J, HILL, Stephen J, KHAN, Raheela N, LYMN, Joanne S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bradykinin - pharmacology Cadaverine - analogs & derivatives Cadaverine - pharmacology Calcium Signaling - drug effects Cystamine - pharmacology Enzyme Inhibitors - pharmacology Female Fundamental and applied biological sciences. Psychology GTP-Binding Proteins Humans Imidazoles - pharmacology In Vitro Techniques Myometrium - drug effects Myometrium - physiology Norleucine - analogs & derivatives Norleucine - pharmacology Obstetric Labor, Premature - prevention & control Oxytocin - pharmacology Phenylephrine - pharmacology Pregnancy Tocolysis Tocolytic Agents - pharmacology Transglutaminases - antagonists & inhibitors Transglutaminases - physiology Uterine Contraction - drug effects Uterine Contraction - physiology Vertebrates: reproduction
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