Disseminated Rhizomucor pusillus causing early multiorgan failure during hematopoietic stem cell transplantation for severe aplastic anemia
Matched sibling donor hematopoietic stem cell transplantation is the standard of care for severe aplastic anemia, with an overall survival of 80% to 90%. Only 60% to 70% of patients respond to treatment with immunosuppressive therapy. The main life threatening complications are infections, graft fai...
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| Veröffentlicht in: | Journal of pediatric hematology/oncology 2011-04, Vol.33 (3), p.235-237 |
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| container_issue | 3 |
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| container_title | Journal of pediatric hematology/oncology |
| container_volume | 33 |
| creator | Rawlinson, Neil J Fung, Bonita Gross, Thomas G Termuhlen, Amanda M Skeens, Micah Garee, Amy Soni, Sandeep Pietryga, Daniel Bajwa, Rajinder P S |
| description | Matched sibling donor hematopoietic stem cell transplantation is the standard of care for severe aplastic anemia, with an overall survival of 80% to 90%. Only 60% to 70% of patients respond to treatment with immunosuppressive therapy. The main life threatening complications are infections, graft failure, and graft versus host disease. A 10-year-old patient with severe aplastic anemia underwent matched sibling donor hematopoietic stem cell transplantation, but developed sudden onset of fatal multiorgan failure on day +12. The cause of death was found only after autopsy. |
| doi_str_mv | 10.1097/MPH.0b013e3182050a4f |
| format | Article |
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| identifier | ISSN: 1077-4114 |
| ispartof | Journal of pediatric hematology/oncology, 2011-04, Vol.33 (3), p.235-237 |
| issn | 1077-4114 1536-3678 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Amphotericin B - therapeutic use Anemia, Aplastic - surgery Child Female Hematopoietic Stem Cell Transplantation - adverse effects Humans Mucormycosis - complications Mucormycosis - drug therapy Multiple Organ Failure - etiology Pyrimidines - therapeutic use Rhizomucor Triazoles - therapeutic use Voriconazole |
| title | Disseminated Rhizomucor pusillus causing early multiorgan failure during hematopoietic stem cell transplantation for severe aplastic anemia |
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