Gene expression profiling of human hepatoblastoma using archived formalin-fixed and paraffin-embedded tissues
We elucidated the genetic profile of hepatoblastomas (HBLs) to identify diagnostic and prognostic markers. RNA was extracted from 32 formalin-fixed, paraffin-embedded HBLs and corresponding nonneoplastic liver (NNL) tissues, and cDNA-mediated annealing, selection, extension, and ligation (DASL) chip...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2011-04, Vol.458 (4), p.453-465 |
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| creator | Shin, Eun Lee, Kyoung-Bun Park, Soo-Young Kim, Soo-Hee Ryu, Han-Suk Park, Young-Nyun Yu, Eunsil Jang, Ja-June |
| description | We elucidated the genetic profile of hepatoblastomas (HBLs) to identify diagnostic and prognostic markers. RNA was extracted from 32 formalin-fixed, paraffin-embedded HBLs and corresponding nonneoplastic liver (NNL) tissues, and cDNA-mediated annealing, selection, extension, and ligation (DASL) chip assays were performed. Immunohistochemistry was performed to confirm the expression of Yin Yang 1 (
YY1
) protein in HBL. Twenty-four genes that were associated with signal transduction, cell–cell adhesion, cell cycle regulation, and apoptosis were differentially expressed in HBL and NNL tissues. Two apoptosis-associated genes,
MYCN
and
BIRC5
, were highly upregulated in HBL. Eight genes, including
YY1
and
IGF1
, were upregulated in HBL cases that had a poor prognosis. Thirty-eight genes, including
YY1
, were differentially expressed according to histologic differentiation of HBL, and the immunohistochemical expression of
YY1
was correlated with poor HBL differentiation. Thus, using DASL chip assays, we report the gene expression profiles of HBL, which suggest new candidate prognostic and diagnostic genetic markers and putative therapeutic targets for HBL. |
| doi_str_mv | 10.1007/s00428-011-1043-8 |
| format | Article |
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YY1
) protein in HBL. Twenty-four genes that were associated with signal transduction, cell–cell adhesion, cell cycle regulation, and apoptosis were differentially expressed in HBL and NNL tissues. Two apoptosis-associated genes,
MYCN
and
BIRC5
, were highly upregulated in HBL. Eight genes, including
YY1
and
IGF1
, were upregulated in HBL cases that had a poor prognosis. Thirty-eight genes, including
YY1
, were differentially expressed according to histologic differentiation of HBL, and the immunohistochemical expression of
YY1
was correlated with poor HBL differentiation. Thus, using DASL chip assays, we report the gene expression profiles of HBL, which suggest new candidate prognostic and diagnostic genetic markers and putative therapeutic targets for HBL.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-011-1043-8</identifier><identifier>PMID: 21369802</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - genetics ; Child ; Child, Preschool ; Female ; Formaldehyde ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Expression ; Gene Expression Profiling - methods ; Genetic markers ; Hepatoblastoma - genetics ; Hepatoblastoma - mortality ; Hepatoblastoma - pathology ; Humans ; Immunohistochemistry ; Infant ; Investigative techniques, diagnostic techniques (general aspects) ; Kaplan-Meier Estimate ; Liver Neoplasms - genetics ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Oligonucleotide Array Sequence Analysis ; Original Article ; Other diseases. Semiology ; Paraffin Embedding ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Prognosis ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - analysis ; RNA, Messenger - isolation & purification ; Tissue Fixation</subject><ispartof>Virchows Archiv : an international journal of pathology, 2011-04, Vol.458 (4), p.453-465</ispartof><rights>Springer-Verlag 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-8142039b2a7d5dae0c0873d1df02821ac911add68175ec6a535f120368d54f3a3</citedby><cites>FETCH-LOGICAL-c433t-8142039b2a7d5dae0c0873d1df02821ac911add68175ec6a535f120368d54f3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00428-011-1043-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00428-011-1043-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24038306$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21369802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Eun</creatorcontrib><creatorcontrib>Lee, Kyoung-Bun</creatorcontrib><creatorcontrib>Park, Soo-Young</creatorcontrib><creatorcontrib>Kim, Soo-Hee</creatorcontrib><creatorcontrib>Ryu, Han-Suk</creatorcontrib><creatorcontrib>Park, Young-Nyun</creatorcontrib><creatorcontrib>Yu, Eunsil</creatorcontrib><creatorcontrib>Jang, Ja-June</creatorcontrib><title>Gene expression profiling of human hepatoblastoma using archived formalin-fixed and paraffin-embedded tissues</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><addtitle>Virchows Arch</addtitle><description>We elucidated the genetic profile of hepatoblastomas (HBLs) to identify diagnostic and prognostic markers. RNA was extracted from 32 formalin-fixed, paraffin-embedded HBLs and corresponding nonneoplastic liver (NNL) tissues, and cDNA-mediated annealing, selection, extension, and ligation (DASL) chip assays were performed. Immunohistochemistry was performed to confirm the expression of Yin Yang 1 (
YY1
) protein in HBL. Twenty-four genes that were associated with signal transduction, cell–cell adhesion, cell cycle regulation, and apoptosis were differentially expressed in HBL and NNL tissues. Two apoptosis-associated genes,
MYCN
and
BIRC5
, were highly upregulated in HBL. Eight genes, including
YY1
and
IGF1
, were upregulated in HBL cases that had a poor prognosis. Thirty-eight genes, including
YY1
, were differentially expressed according to histologic differentiation of HBL, and the immunohistochemical expression of
YY1
was correlated with poor HBL differentiation. Thus, using DASL chip assays, we report the gene expression profiles of HBL, which suggest new candidate prognostic and diagnostic genetic markers and putative therapeutic targets for HBL.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Formaldehyde</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Expression</subject><subject>Gene Expression Profiling - methods</subject><subject>Genetic markers</subject><subject>Hepatoblastoma - genetics</subject><subject>Hepatoblastoma - mortality</subject><subject>Hepatoblastoma - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Infant</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kaplan-Meier Estimate</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Original Article</subject><subject>Other diseases. Semiology</subject><subject>Paraffin Embedding</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Prognosis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - isolation & purification</subject><subject>Tissue Fixation</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kVtrVTEQhYMo9rT6A3yRjSD1JTqT7EvyKEWrUOhLfQ5zculJ2TeTvaX-e3M4RwtC-xQy861ZMyzG3iB8RIDuUwaoheKAyBFqydUztsFaCi4kdM_ZBnTd8FZid8JOc74DEKiwfclOBMpWKxAbNlz60Vf-fk4-5ziN1ZymEPs43lZTqHbrQGO18zMt07anvEwDVWvedynZXfzlXRWmNFAR8BDvy5dGV82UKIRS8sPWO1eqS8x59fkVexGoz_718T1jP75-ubn4xq-uL79ffL7itpZy4QprAVJvBXWuceTBguqkQxdAKIFkNSI51yrsGm9bamQTsCha5Zo6SJJn7Pwwt1zzs_guZojZ-r6n0U9rNqpRQimJqpAfniSLg6wbjVoU9N1_6N20prHcUeZ1WuumhgLhAbJpyjn5YOYUB0q_DYLZh2YOoZkSmtmHZvY7vD0OXreDd_8Uf1MqwPsjQNlSHxKNNuYHrvgqCW3hxIHLpTXe-vSw4ePufwDY3a7L</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Shin, Eun</creator><creator>Lee, Kyoung-Bun</creator><creator>Park, Soo-Young</creator><creator>Kim, Soo-Hee</creator><creator>Ryu, Han-Suk</creator><creator>Park, Young-Nyun</creator><creator>Yu, Eunsil</creator><creator>Jang, Ja-June</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Gene expression profiling of human hepatoblastoma using archived formalin-fixed and paraffin-embedded tissues</title><author>Shin, Eun ; Lee, Kyoung-Bun ; Park, Soo-Young ; Kim, Soo-Hee ; Ryu, Han-Suk ; Park, Young-Nyun ; Yu, Eunsil ; Jang, Ja-June</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-8142039b2a7d5dae0c0873d1df02821ac911add68175ec6a535f120368d54f3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Formaldehyde</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gene Expression</topic><topic>Gene Expression Profiling - methods</topic><topic>Genetic markers</topic><topic>Hepatoblastoma - genetics</topic><topic>Hepatoblastoma - mortality</topic><topic>Hepatoblastoma - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Infant</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Kaplan-Meier Estimate</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Original Article</topic><topic>Other diseases. Semiology</topic><topic>Paraffin Embedding</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. 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RNA was extracted from 32 formalin-fixed, paraffin-embedded HBLs and corresponding nonneoplastic liver (NNL) tissues, and cDNA-mediated annealing, selection, extension, and ligation (DASL) chip assays were performed. Immunohistochemistry was performed to confirm the expression of Yin Yang 1 (
YY1
) protein in HBL. Twenty-four genes that were associated with signal transduction, cell–cell adhesion, cell cycle regulation, and apoptosis were differentially expressed in HBL and NNL tissues. Two apoptosis-associated genes,
MYCN
and
BIRC5
, were highly upregulated in HBL. Eight genes, including
YY1
and
IGF1
, were upregulated in HBL cases that had a poor prognosis. Thirty-eight genes, including
YY1
, were differentially expressed according to histologic differentiation of HBL, and the immunohistochemical expression of
YY1
was correlated with poor HBL differentiation. Thus, using DASL chip assays, we report the gene expression profiles of HBL, which suggest new candidate prognostic and diagnostic genetic markers and putative therapeutic targets for HBL.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21369802</pmid><doi>10.1007/s00428-011-1043-8</doi><tpages>13</tpages></addata></record> |
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| subjects | Adolescent Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Child Child, Preschool Female Formaldehyde Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Gene Expression Profiling - methods Genetic markers Hepatoblastoma - genetics Hepatoblastoma - mortality Hepatoblastoma - pathology Humans Immunohistochemistry Infant Investigative techniques, diagnostic techniques (general aspects) Kaplan-Meier Estimate Liver Neoplasms - genetics Liver Neoplasms - mortality Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Medicine Medicine & Public Health Oligonucleotide Array Sequence Analysis Original Article Other diseases. Semiology Paraffin Embedding Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prognosis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis RNA, Messenger - isolation & purification Tissue Fixation |
| title | Gene expression profiling of human hepatoblastoma using archived formalin-fixed and paraffin-embedded tissues |
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