Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosis
BackgroundOsteoprotegerin (OPG) and receptor activator of nuclear factor κ B ligand (RANKL) play a critical role in the regulation of bone turnover, but the relative importance of these two cytokines in the pathogenesis of postmenopausal osteoporosis is controversial.AimTo investigate the relationsh...
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| creator | Jabbar, Suhair Drury, John Fordham, John N Datta, Harish K Francis, Roger M Tuck, Stephen P |
| description | BackgroundOsteoprotegerin (OPG) and receptor activator of nuclear factor κ B ligand (RANKL) play a critical role in the regulation of bone turnover, but the relative importance of these two cytokines in the pathogenesis of postmenopausal osteoporosis is controversial.AimTo investigate the relationship between circulating levels of OPG, RANKL, bone turnover and bone mineral density (BMD) in postmenopausal women.MethodsA cross-sectional study of 185 women with osteoporosis and 185 age- and sex-matched control subjects was undertaken. Measurements were made of plasma OPG, RANKL, interleukin-6 (IL-6), sex steroids, calciotropic hormones, biochemical markers of bone turnover, BMD and anthropometry. Health questionnaires were administered.ResultsPlasma RANKL was significantly higher (p |
| doi_str_mv | 10.1136/jcp.2010.086595 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_858287607</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4022586201</sourcerecordid><originalsourceid>FETCH-LOGICAL-b539t-fdd6fa4684231dedecee4a68c86f31d05c49d5cd53943cf9bb9d5201aceea3113</originalsourceid><addsrcrecordid>eNqF0M-L1TAQB_AgivtcPXuTgoggdjfT_D4uD11lH7u4qNeQpqn02TY1aUX_e-fZ5wpePIVJPhNmvoQ8BXoGwOT53k9nFcWKaimMuEc2wFVVcuDyPtlQWkFpFJcn5FHOe0qBKWAPyUkFjCoQYkMub_Ic4pTiHL6E1I2vi9uL66td4camqOMYinlJY_weUtGNxRTzPIQxTm7Jri_i79aYYu7yY_KgdX0OT47nKfn09s3H7btyd3P5fnuxK2vBzFy2TSNbx6XmFYMmNMGHwJ3UXssWL6jw3DTCN4g5862payxxQYfOMVz5lLxc_8WRvy0hz3bosg9978YQl2y10JVWkiqUz_-R-4i74HAWlAbKFKsMqvNVeVwjp9DaKXWDSz8tUHuI2GLE9hCxXSPGjmfHf5d6CM2d_5MpghdH4LJ3fZvc6Lv81zGjwVQMXbm6DnP8cffu0lcrFVPCXn_e2lsDH7SCK3vwr1ZfD_v_TvkL2R6gNA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781037329</pqid></control><display><type>article</type><title>Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosis</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Jabbar, Suhair ; Drury, John ; Fordham, John N ; Datta, Harish K ; Francis, Roger M ; Tuck, Stephen P</creator><creatorcontrib>Jabbar, Suhair ; Drury, John ; Fordham, John N ; Datta, Harish K ; Francis, Roger M ; Tuck, Stephen P</creatorcontrib><description>BackgroundOsteoprotegerin (OPG) and receptor activator of nuclear factor κ B ligand (RANKL) play a critical role in the regulation of bone turnover, but the relative importance of these two cytokines in the pathogenesis of postmenopausal osteoporosis is controversial.AimTo investigate the relationship between circulating levels of OPG, RANKL, bone turnover and bone mineral density (BMD) in postmenopausal women.MethodsA cross-sectional study of 185 women with osteoporosis and 185 age- and sex-matched control subjects was undertaken. Measurements were made of plasma OPG, RANKL, interleukin-6 (IL-6), sex steroids, calciotropic hormones, biochemical markers of bone turnover, BMD and anthropometry. Health questionnaires were administered.ResultsPlasma RANKL was significantly higher (p<0.0001) in women with osteoporosis (0.66±0.67 pmol/l) than in control subjects (0.37±0.38 pmol/l), as was plasma OPG (18.70±9.70 pmol/l in women with osteoporosis, 10.44±5.85 pmol/l in control subjects; p<0.0001). OPG/RANKL ratio was higher in women with osteoporosis (51.3) than in control subjects (36.6). The women with osteoporosis also had significantly higher biochemical markers of bone turnover, IL-6 and parathyroid hormone and lower 25-hydroxyvitamin D and oestradiol than the control subjects. Multiple regression analysis showed that lumbar spine and femoral neck BMD in postmenopausal women were best predicted by OPG and RANKL, giving an R2 value of 15.5% and 14.9%, respectively.ConclusionsThis study indicates that the circulating levels of OPG and RANKL are inversely related to BMD and contribute to the development of osteoporosis in postmenopausal women.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.2010.086595</identifier><identifier>PMID: 21307155</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Absorptiometry, Photon - methods ; Age ; Aged ; ageing ; Anthropometry - methods ; Biological and medical sciences ; Biomarkers - blood ; bone ; bone cells ; Bone density ; Bone Density - physiology ; Bone mineral density ; bone pathology ; Bone Remodeling - physiology ; Case-Control Studies ; Cross-Sectional Studies ; Cytokines ; Diseases of the osteoarticular system ; Female ; Femur Neck - physiopathology ; Humans ; Immunoassay ; Investigative techniques, diagnostic techniques (general aspects) ; Ligands ; Lumbar Vertebrae - physiopathology ; Medical sciences ; Middle Aged ; Osteoporosis ; Osteoporosis, Postmenopausal - blood ; Osteoporosis, Postmenopausal - physiopathology ; Osteoporosis. Osteomalacia. Paget disease ; osteoprotegerin ; Osteoprotegerin - blood ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; RANK ; RANK Ligand - blood ; RANKL ; rheumatological pathology ; Statistical analysis ; Studies</subject><ispartof>Journal of clinical pathology, 2011-04, Vol.64 (4), p.354-357</ispartof><rights>2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2011 (c) 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b539t-fdd6fa4684231dedecee4a68c86f31d05c49d5cd53943cf9bb9d5201aceea3113</citedby><cites>FETCH-LOGICAL-b539t-fdd6fa4684231dedecee4a68c86f31d05c49d5cd53943cf9bb9d5201aceea3113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jcp.bmj.com/content/64/4/354.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jcp.bmj.com/content/64/4/354.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23550,27901,27902,77342,77373</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23981923$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21307155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jabbar, Suhair</creatorcontrib><creatorcontrib>Drury, John</creatorcontrib><creatorcontrib>Fordham, John N</creatorcontrib><creatorcontrib>Datta, Harish K</creatorcontrib><creatorcontrib>Francis, Roger M</creatorcontrib><creatorcontrib>Tuck, Stephen P</creatorcontrib><title>Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosis</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>BackgroundOsteoprotegerin (OPG) and receptor activator of nuclear factor κ B ligand (RANKL) play a critical role in the regulation of bone turnover, but the relative importance of these two cytokines in the pathogenesis of postmenopausal osteoporosis is controversial.AimTo investigate the relationship between circulating levels of OPG, RANKL, bone turnover and bone mineral density (BMD) in postmenopausal women.MethodsA cross-sectional study of 185 women with osteoporosis and 185 age- and sex-matched control subjects was undertaken. Measurements were made of plasma OPG, RANKL, interleukin-6 (IL-6), sex steroids, calciotropic hormones, biochemical markers of bone turnover, BMD and anthropometry. Health questionnaires were administered.ResultsPlasma RANKL was significantly higher (p<0.0001) in women with osteoporosis (0.66±0.67 pmol/l) than in control subjects (0.37±0.38 pmol/l), as was plasma OPG (18.70±9.70 pmol/l in women with osteoporosis, 10.44±5.85 pmol/l in control subjects; p<0.0001). OPG/RANKL ratio was higher in women with osteoporosis (51.3) than in control subjects (36.6). The women with osteoporosis also had significantly higher biochemical markers of bone turnover, IL-6 and parathyroid hormone and lower 25-hydroxyvitamin D and oestradiol than the control subjects. Multiple regression analysis showed that lumbar spine and femoral neck BMD in postmenopausal women were best predicted by OPG and RANKL, giving an R2 value of 15.5% and 14.9%, respectively.ConclusionsThis study indicates that the circulating levels of OPG and RANKL are inversely related to BMD and contribute to the development of osteoporosis in postmenopausal women.</description><subject>Absorptiometry, Photon - methods</subject><subject>Age</subject><subject>Aged</subject><subject>ageing</subject><subject>Anthropometry - methods</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>bone</subject><subject>bone cells</subject><subject>Bone density</subject><subject>Bone Density - physiology</subject><subject>Bone mineral density</subject><subject>bone pathology</subject><subject>Bone Remodeling - physiology</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Cytokines</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Femur Neck - physiopathology</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Ligands</subject><subject>Lumbar Vertebrae - physiopathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osteoporosis</subject><subject>Osteoporosis, Postmenopausal - blood</subject><subject>Osteoporosis, Postmenopausal - physiopathology</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>osteoprotegerin</subject><subject>Osteoprotegerin - blood</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>RANK</subject><subject>RANK Ligand - blood</subject><subject>RANKL</subject><subject>rheumatological pathology</subject><subject>Statistical analysis</subject><subject>Studies</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0M-L1TAQB_AgivtcPXuTgoggdjfT_D4uD11lH7u4qNeQpqn02TY1aUX_e-fZ5wpePIVJPhNmvoQ8BXoGwOT53k9nFcWKaimMuEc2wFVVcuDyPtlQWkFpFJcn5FHOe0qBKWAPyUkFjCoQYkMub_Ic4pTiHL6E1I2vi9uL66td4camqOMYinlJY_weUtGNxRTzPIQxTm7Jri_i79aYYu7yY_KgdX0OT47nKfn09s3H7btyd3P5fnuxK2vBzFy2TSNbx6XmFYMmNMGHwJ3UXssWL6jw3DTCN4g5862payxxQYfOMVz5lLxc_8WRvy0hz3bosg9978YQl2y10JVWkiqUz_-R-4i74HAWlAbKFKsMqvNVeVwjp9DaKXWDSz8tUHuI2GLE9hCxXSPGjmfHf5d6CM2d_5MpghdH4LJ3fZvc6Lv81zGjwVQMXbm6DnP8cffu0lcrFVPCXn_e2lsDH7SCK3vwr1ZfD_v_TvkL2R6gNA</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Jabbar, Suhair</creator><creator>Drury, John</creator><creator>Fordham, John N</creator><creator>Datta, Harish K</creator><creator>Francis, Roger M</creator><creator>Tuck, Stephen P</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosis</title><author>Jabbar, Suhair ; Drury, John ; Fordham, John N ; Datta, Harish K ; Francis, Roger M ; Tuck, Stephen P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b539t-fdd6fa4684231dedecee4a68c86f31d05c49d5cd53943cf9bb9d5201aceea3113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Absorptiometry, Photon - methods</topic><topic>Age</topic><topic>Aged</topic><topic>ageing</topic><topic>Anthropometry - methods</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>bone</topic><topic>bone cells</topic><topic>Bone density</topic><topic>Bone Density - physiology</topic><topic>Bone mineral density</topic><topic>bone pathology</topic><topic>Bone Remodeling - physiology</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Cytokines</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Femur Neck - physiopathology</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Ligands</topic><topic>Lumbar Vertebrae - physiopathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Osteoporosis</topic><topic>Osteoporosis, Postmenopausal - blood</topic><topic>Osteoporosis, Postmenopausal - physiopathology</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>osteoprotegerin</topic><topic>Osteoprotegerin - blood</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>RANK</topic><topic>RANK Ligand - blood</topic><topic>RANKL</topic><topic>rheumatological pathology</topic><topic>Statistical analysis</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jabbar, Suhair</creatorcontrib><creatorcontrib>Drury, John</creatorcontrib><creatorcontrib>Fordham, John N</creatorcontrib><creatorcontrib>Datta, Harish K</creatorcontrib><creatorcontrib>Francis, Roger M</creatorcontrib><creatorcontrib>Tuck, Stephen P</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jabbar, Suhair</au><au>Drury, John</au><au>Fordham, John N</au><au>Datta, Harish K</au><au>Francis, Roger M</au><au>Tuck, Stephen P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosis</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>64</volume><issue>4</issue><spage>354</spage><epage>357</epage><pages>354-357</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>BackgroundOsteoprotegerin (OPG) and receptor activator of nuclear factor κ B ligand (RANKL) play a critical role in the regulation of bone turnover, but the relative importance of these two cytokines in the pathogenesis of postmenopausal osteoporosis is controversial.AimTo investigate the relationship between circulating levels of OPG, RANKL, bone turnover and bone mineral density (BMD) in postmenopausal women.MethodsA cross-sectional study of 185 women with osteoporosis and 185 age- and sex-matched control subjects was undertaken. Measurements were made of plasma OPG, RANKL, interleukin-6 (IL-6), sex steroids, calciotropic hormones, biochemical markers of bone turnover, BMD and anthropometry. Health questionnaires were administered.ResultsPlasma RANKL was significantly higher (p<0.0001) in women with osteoporosis (0.66±0.67 pmol/l) than in control subjects (0.37±0.38 pmol/l), as was plasma OPG (18.70±9.70 pmol/l in women with osteoporosis, 10.44±5.85 pmol/l in control subjects; p<0.0001). OPG/RANKL ratio was higher in women with osteoporosis (51.3) than in control subjects (36.6). The women with osteoporosis also had significantly higher biochemical markers of bone turnover, IL-6 and parathyroid hormone and lower 25-hydroxyvitamin D and oestradiol than the control subjects. Multiple regression analysis showed that lumbar spine and femoral neck BMD in postmenopausal women were best predicted by OPG and RANKL, giving an R2 value of 15.5% and 14.9%, respectively.ConclusionsThis study indicates that the circulating levels of OPG and RANKL are inversely related to BMD and contribute to the development of osteoporosis in postmenopausal women.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>21307155</pmid><doi>10.1136/jcp.2010.086595</doi><tpages>4</tpages></addata></record> |
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| subjects | Absorptiometry, Photon - methods Age Aged ageing Anthropometry - methods Biological and medical sciences Biomarkers - blood bone bone cells Bone density Bone Density - physiology Bone mineral density bone pathology Bone Remodeling - physiology Case-Control Studies Cross-Sectional Studies Cytokines Diseases of the osteoarticular system Female Femur Neck - physiopathology Humans Immunoassay Investigative techniques, diagnostic techniques (general aspects) Ligands Lumbar Vertebrae - physiopathology Medical sciences Middle Aged Osteoporosis Osteoporosis, Postmenopausal - blood Osteoporosis, Postmenopausal - physiopathology Osteoporosis. Osteomalacia. Paget disease osteoprotegerin Osteoprotegerin - blood Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques RANK RANK Ligand - blood RANKL rheumatological pathology Statistical analysis Studies |
| title | Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosis |
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