Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating thiocarbamates

The thiocarbamates 4-RC 6H 4NHC(S)NR 2′ (R = H, Cl; R′ = Me, Et), 4-ClC 6H 4NHC(S)NR (NR = 2-pyridylpiperazine) react with cis-[PtCl 2(PTA) 2] (PTA = 1,3,5-triaza-7-phosphaadamantane) in the presence of base to afford the monocationic platinum(II) complexes cis-[Pt{SC(NR 2′) = NC 6H 4R}(PTA) 2] + (R...

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Veröffentlicht in:	Journal of inorganic biochemistry 2011-03, Vol.105 (3), p.462-466
Hauptverfasser:	Bippus, Patrick, Skocic, Matthias, Jakupec, Michael A., Keppler, Bernhard K., Mohr, Fabian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - chemistry Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cations, Divalent Chelating Agents - chemistry cis geometry Crystallography, X-Ray Cytotoxicity Drug Screening Assays, Antitumor Humans Inhibitory Concentration 50 Organophosphorus Compounds - chemistry Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Piperazines - chemistry Pt complexes Pyridines - chemistry Stereoisomerism Thiocarbamate ligands Thiocarbamates - chemistry Tumor Cells, Cultured X-ray structure
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