Association between High-Sensitivity C-Reactive Protein and Left Ventricular Diastolic Function Assessed by Echocardiography in Patients with Cardiovascular Risk Factors
High-sensitivity C-reactive protein (hsCRP) has been demonstrated to play a causal role in atherosclerosis and to predict cardiovascular events in the general population. On the other hand, left ventricular (LV) hypertrophy and diastolic dysfunction assessed by echocardiography can also predict card...
Gespeichert in:
| Veröffentlicht in: | The Tohoku Journal of Experimental Medicine 2011, Vol.223(4), pp.263-268 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 268 |
|---|---|
| container_issue | 4 |
| container_start_page | 263 |
| container_title | The Tohoku Journal of Experimental Medicine |
| container_volume | 223 |
| creator | Masugata, Hisashi Senda, Shoichi Inukai, Michio Murao, Koji Tada, Satoshi Hosomi, Naohisa Iwado, Yasuyoshi Noma, Takahisa Kohno, Masakazu Himoto, Takashi Goda, Fuminori |
| description | High-sensitivity C-reactive protein (hsCRP) has been demonstrated to play a causal role in atherosclerosis and to predict cardiovascular events in the general population. On the other hand, left ventricular (LV) hypertrophy and diastolic dysfunction assessed by echocardiography can also predict cardiovascular events in patients with cardiovascular risk factors. However, there are few data regarding the relationships among hsCRP, LV hypertrophy, and diastolic function. We examined the relationships among hsCRP, LV hypertrophy, and diastolic function in 185 patients (65 ± 11 years), who had no overt heart disease, but had cardiovascular risk factors, including hypertension, diabetes, and dyslipidemia. Echocardiography was performed to measure the left ventricular mass index (LVMI) as a parameter of LV hypertrophy. LV diastolic function was assessed by the ratio (E/A) of early (E) and late (A) diastolic transmitral flows, early diastolic mitral annular velocity (E'), and the ratio (E/E') of E to E' using Doppler echocardiography. The hsCRP was correlated with LVMI (r = 0.228, p = 0.002), E' (r = −0.276, p < 0.001), and E/E' (r = 0.419, p < 0.001). The E/E' as a parameter of LV diastolic function showed the closest correlation to hsCRP. These results indicate that elevated hsCRP reflects LV diastolic dysfunction rather than LV hypertrophy. We therefore suggest that hsCRP may be a marker of subclinical LV diastolic dysfunction in patients with cardiovascular risk factors. |
| doi_str_mv | 10.1620/tjem.223.263 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_858287183</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>858287183</sourcerecordid><originalsourceid>FETCH-LOGICAL-c506t-18e175a674d066dd681f925f1621ad5fc4e062ce605827dc3022f497047f67aa3</originalsourceid><addsrcrecordid>eNpFkU1vEzEQhi0Eomnhxhn5xqUb_LX25lhCQ5EiUZWWq-XYs1mHzTrY3lb5SfxL3KYNkmVrNI-fkeZF6AMlUyoZ-Zw3sJ0yxqdM8ldoQrmYVZyz2Ws0IUSQqlFMnaDTlDaEcEGUfItOGBWMKSEn6O9FSsF6k30Y8AryA8CAr_y6q37CkHz29z7v8by6AWNLAfg6hgx-wGZweAltxr9gyNHbsTcRf_Um5dB7ixfjYJ-cxQ_lOLza40vbBWui82Edza7b4-K5LqOLIeEHnzs8f-rem3Tw3fj0Gy_K5BDTO_SmNX2C98_vGbpbXN7Or6rlj2_f5xfLytZE5oo2QFVtpBKOSOmcbGg7Y3VbdkWNq1srgEhmQZK6YcpZThhrxUwRoVqpjOFn6NPBu4vhzwgp661PFvreDBDGpJvyr1G04YU8P5A2hpQitHoX_dbEvaZEP2ajH7PRJRtdsin4x2fxuNqCO8IvYRTgywHYpGzWcARMzN728N8mXm7Jj03bmahh4P8A9XqluQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>858287183</pqid></control><display><type>article</type><title>Association between High-Sensitivity C-Reactive Protein and Left Ventricular Diastolic Function Assessed by Echocardiography in Patients with Cardiovascular Risk Factors</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Open Access Titles of Japan</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Masugata, Hisashi ; Senda, Shoichi ; Inukai, Michio ; Murao, Koji ; Tada, Satoshi ; Hosomi, Naohisa ; Iwado, Yasuyoshi ; Noma, Takahisa ; Kohno, Masakazu ; Himoto, Takashi ; Goda, Fuminori</creator><creatorcontrib>Masugata, Hisashi ; Senda, Shoichi ; Inukai, Michio ; Murao, Koji ; Tada, Satoshi ; Hosomi, Naohisa ; Iwado, Yasuyoshi ; Noma, Takahisa ; Kohno, Masakazu ; Himoto, Takashi ; Goda, Fuminori</creatorcontrib><description>High-sensitivity C-reactive protein (hsCRP) has been demonstrated to play a causal role in atherosclerosis and to predict cardiovascular events in the general population. On the other hand, left ventricular (LV) hypertrophy and diastolic dysfunction assessed by echocardiography can also predict cardiovascular events in patients with cardiovascular risk factors. However, there are few data regarding the relationships among hsCRP, LV hypertrophy, and diastolic function. We examined the relationships among hsCRP, LV hypertrophy, and diastolic function in 185 patients (65 ± 11 years), who had no overt heart disease, but had cardiovascular risk factors, including hypertension, diabetes, and dyslipidemia. Echocardiography was performed to measure the left ventricular mass index (LVMI) as a parameter of LV hypertrophy. LV diastolic function was assessed by the ratio (E/A) of early (E) and late (A) diastolic transmitral flows, early diastolic mitral annular velocity (E'), and the ratio (E/E') of E to E' using Doppler echocardiography. The hsCRP was correlated with LVMI (r = 0.228, p = 0.002), E' (r = −0.276, p < 0.001), and E/E' (r = 0.419, p < 0.001). The E/E' as a parameter of LV diastolic function showed the closest correlation to hsCRP. These results indicate that elevated hsCRP reflects LV diastolic dysfunction rather than LV hypertrophy. We therefore suggest that hsCRP may be a marker of subclinical LV diastolic dysfunction in patients with cardiovascular risk factors.</description><identifier>ISSN: 0040-8727</identifier><identifier>EISSN: 1349-3329</identifier><identifier>DOI: 10.1620/tjem.223.263</identifier><identifier>PMID: 21422746</identifier><language>eng</language><publisher>Japan: Tohoku University Medical Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; C-Reactive Protein - analysis ; C-Reactive Protein - metabolism ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnostic imaging ; Cardiovascular Diseases - etiology ; cardiovascular risk factor ; Cohort Studies ; Diabetes Complications - blood ; Diabetes Complications - diagnostic imaging ; Diabetes Complications - physiopathology ; Diastole - physiology ; Dyslipidemias - blood ; Dyslipidemias - complications ; Dyslipidemias - diagnostic imaging ; Dyslipidemias - physiopathology ; Echocardiography ; Female ; Heart Ventricles - diagnostic imaging ; high-sensitive CRP ; Humans ; Hypertension - blood ; Hypertension - complications ; Hypertension - diagnostic imaging ; Hypertension - physiopathology ; left ventricular diastolic dysfunction ; left ventricular hypertrophy ; Male ; Middle Aged ; Risk Factors ; Ventricular Function, Left - physiology ; Young Adult</subject><ispartof>The Tohoku Journal of Experimental Medicine, 2011, Vol.223(4), pp.263-268</ispartof><rights>2011 Tohoku University Medical Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-18e175a674d066dd681f925f1621ad5fc4e062ce605827dc3022f497047f67aa3</citedby><cites>FETCH-LOGICAL-c506t-18e175a674d066dd681f925f1621ad5fc4e062ce605827dc3022f497047f67aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21422746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masugata, Hisashi</creatorcontrib><creatorcontrib>Senda, Shoichi</creatorcontrib><creatorcontrib>Inukai, Michio</creatorcontrib><creatorcontrib>Murao, Koji</creatorcontrib><creatorcontrib>Tada, Satoshi</creatorcontrib><creatorcontrib>Hosomi, Naohisa</creatorcontrib><creatorcontrib>Iwado, Yasuyoshi</creatorcontrib><creatorcontrib>Noma, Takahisa</creatorcontrib><creatorcontrib>Kohno, Masakazu</creatorcontrib><creatorcontrib>Himoto, Takashi</creatorcontrib><creatorcontrib>Goda, Fuminori</creatorcontrib><title>Association between High-Sensitivity C-Reactive Protein and Left Ventricular Diastolic Function Assessed by Echocardiography in Patients with Cardiovascular Risk Factors</title><title>The Tohoku Journal of Experimental Medicine</title><addtitle>Tohoku J. Exp. Med.</addtitle><description>High-sensitivity C-reactive protein (hsCRP) has been demonstrated to play a causal role in atherosclerosis and to predict cardiovascular events in the general population. On the other hand, left ventricular (LV) hypertrophy and diastolic dysfunction assessed by echocardiography can also predict cardiovascular events in patients with cardiovascular risk factors. However, there are few data regarding the relationships among hsCRP, LV hypertrophy, and diastolic function. We examined the relationships among hsCRP, LV hypertrophy, and diastolic function in 185 patients (65 ± 11 years), who had no overt heart disease, but had cardiovascular risk factors, including hypertension, diabetes, and dyslipidemia. Echocardiography was performed to measure the left ventricular mass index (LVMI) as a parameter of LV hypertrophy. LV diastolic function was assessed by the ratio (E/A) of early (E) and late (A) diastolic transmitral flows, early diastolic mitral annular velocity (E'), and the ratio (E/E') of E to E' using Doppler echocardiography. The hsCRP was correlated with LVMI (r = 0.228, p = 0.002), E' (r = −0.276, p < 0.001), and E/E' (r = 0.419, p < 0.001). The E/E' as a parameter of LV diastolic function showed the closest correlation to hsCRP. These results indicate that elevated hsCRP reflects LV diastolic dysfunction rather than LV hypertrophy. We therefore suggest that hsCRP may be a marker of subclinical LV diastolic dysfunction in patients with cardiovascular risk factors.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>C-Reactive Protein - analysis</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - diagnostic imaging</subject><subject>Cardiovascular Diseases - etiology</subject><subject>cardiovascular risk factor</subject><subject>Cohort Studies</subject><subject>Diabetes Complications - blood</subject><subject>Diabetes Complications - diagnostic imaging</subject><subject>Diabetes Complications - physiopathology</subject><subject>Diastole - physiology</subject><subject>Dyslipidemias - blood</subject><subject>Dyslipidemias - complications</subject><subject>Dyslipidemias - diagnostic imaging</subject><subject>Dyslipidemias - physiopathology</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>high-sensitive CRP</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - complications</subject><subject>Hypertension - diagnostic imaging</subject><subject>Hypertension - physiopathology</subject><subject>left ventricular diastolic dysfunction</subject><subject>left ventricular hypertrophy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Ventricular Function, Left - physiology</subject><subject>Young Adult</subject><issn>0040-8727</issn><issn>1349-3329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1vEzEQhi0Eomnhxhn5xqUb_LX25lhCQ5EiUZWWq-XYs1mHzTrY3lb5SfxL3KYNkmVrNI-fkeZF6AMlUyoZ-Zw3sJ0yxqdM8ldoQrmYVZyz2Ws0IUSQqlFMnaDTlDaEcEGUfItOGBWMKSEn6O9FSsF6k30Y8AryA8CAr_y6q37CkHz29z7v8by6AWNLAfg6hgx-wGZweAltxr9gyNHbsTcRf_Um5dB7ixfjYJ-cxQ_lOLza40vbBWui82Edza7b4-K5LqOLIeEHnzs8f-rem3Tw3fj0Gy_K5BDTO_SmNX2C98_vGbpbXN7Or6rlj2_f5xfLytZE5oo2QFVtpBKOSOmcbGg7Y3VbdkWNq1srgEhmQZK6YcpZThhrxUwRoVqpjOFn6NPBu4vhzwgp661PFvreDBDGpJvyr1G04YU8P5A2hpQitHoX_dbEvaZEP2ajH7PRJRtdsin4x2fxuNqCO8IvYRTgywHYpGzWcARMzN728N8mXm7Jj03bmahh4P8A9XqluQ</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Masugata, Hisashi</creator><creator>Senda, Shoichi</creator><creator>Inukai, Michio</creator><creator>Murao, Koji</creator><creator>Tada, Satoshi</creator><creator>Hosomi, Naohisa</creator><creator>Iwado, Yasuyoshi</creator><creator>Noma, Takahisa</creator><creator>Kohno, Masakazu</creator><creator>Himoto, Takashi</creator><creator>Goda, Fuminori</creator><general>Tohoku University Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Association between High-Sensitivity C-Reactive Protein and Left Ventricular Diastolic Function Assessed by Echocardiography in Patients with Cardiovascular Risk Factors</title><author>Masugata, Hisashi ; Senda, Shoichi ; Inukai, Michio ; Murao, Koji ; Tada, Satoshi ; Hosomi, Naohisa ; Iwado, Yasuyoshi ; Noma, Takahisa ; Kohno, Masakazu ; Himoto, Takashi ; Goda, Fuminori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-18e175a674d066dd681f925f1621ad5fc4e062ce605827dc3022f497047f67aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>C-Reactive Protein - analysis</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - diagnostic imaging</topic><topic>Cardiovascular Diseases - etiology</topic><topic>cardiovascular risk factor</topic><topic>Cohort Studies</topic><topic>Diabetes Complications - blood</topic><topic>Diabetes Complications - diagnostic imaging</topic><topic>Diabetes Complications - physiopathology</topic><topic>Diastole - physiology</topic><topic>Dyslipidemias - blood</topic><topic>Dyslipidemias - complications</topic><topic>Dyslipidemias - diagnostic imaging</topic><topic>Dyslipidemias - physiopathology</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>high-sensitive CRP</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - complications</topic><topic>Hypertension - diagnostic imaging</topic><topic>Hypertension - physiopathology</topic><topic>left ventricular diastolic dysfunction</topic><topic>left ventricular hypertrophy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Ventricular Function, Left - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masugata, Hisashi</creatorcontrib><creatorcontrib>Senda, Shoichi</creatorcontrib><creatorcontrib>Inukai, Michio</creatorcontrib><creatorcontrib>Murao, Koji</creatorcontrib><creatorcontrib>Tada, Satoshi</creatorcontrib><creatorcontrib>Hosomi, Naohisa</creatorcontrib><creatorcontrib>Iwado, Yasuyoshi</creatorcontrib><creatorcontrib>Noma, Takahisa</creatorcontrib><creatorcontrib>Kohno, Masakazu</creatorcontrib><creatorcontrib>Himoto, Takashi</creatorcontrib><creatorcontrib>Goda, Fuminori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Tohoku Journal of Experimental Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masugata, Hisashi</au><au>Senda, Shoichi</au><au>Inukai, Michio</au><au>Murao, Koji</au><au>Tada, Satoshi</au><au>Hosomi, Naohisa</au><au>Iwado, Yasuyoshi</au><au>Noma, Takahisa</au><au>Kohno, Masakazu</au><au>Himoto, Takashi</au><au>Goda, Fuminori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between High-Sensitivity C-Reactive Protein and Left Ventricular Diastolic Function Assessed by Echocardiography in Patients with Cardiovascular Risk Factors</atitle><jtitle>The Tohoku Journal of Experimental Medicine</jtitle><addtitle>Tohoku J. Exp. Med.</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>223</volume><issue>4</issue><spage>263</spage><epage>268</epage><pages>263-268</pages><issn>0040-8727</issn><eissn>1349-3329</eissn><abstract>High-sensitivity C-reactive protein (hsCRP) has been demonstrated to play a causal role in atherosclerosis and to predict cardiovascular events in the general population. On the other hand, left ventricular (LV) hypertrophy and diastolic dysfunction assessed by echocardiography can also predict cardiovascular events in patients with cardiovascular risk factors. However, there are few data regarding the relationships among hsCRP, LV hypertrophy, and diastolic function. We examined the relationships among hsCRP, LV hypertrophy, and diastolic function in 185 patients (65 ± 11 years), who had no overt heart disease, but had cardiovascular risk factors, including hypertension, diabetes, and dyslipidemia. Echocardiography was performed to measure the left ventricular mass index (LVMI) as a parameter of LV hypertrophy. LV diastolic function was assessed by the ratio (E/A) of early (E) and late (A) diastolic transmitral flows, early diastolic mitral annular velocity (E'), and the ratio (E/E') of E to E' using Doppler echocardiography. The hsCRP was correlated with LVMI (r = 0.228, p = 0.002), E' (r = −0.276, p < 0.001), and E/E' (r = 0.419, p < 0.001). The E/E' as a parameter of LV diastolic function showed the closest correlation to hsCRP. These results indicate that elevated hsCRP reflects LV diastolic dysfunction rather than LV hypertrophy. We therefore suggest that hsCRP may be a marker of subclinical LV diastolic dysfunction in patients with cardiovascular risk factors.</abstract><cop>Japan</cop><pub>Tohoku University Medical Press</pub><pmid>21422746</pmid><doi>10.1620/tjem.223.263</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0040-8727 |
| ispartof | The Tohoku Journal of Experimental Medicine, 2011, Vol.223(4), pp.263-268 |
| issn | 0040-8727 1349-3329 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_858287183 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Aged, 80 and over C-Reactive Protein - analysis C-Reactive Protein - metabolism Cardiovascular Diseases - blood Cardiovascular Diseases - diagnostic imaging Cardiovascular Diseases - etiology cardiovascular risk factor Cohort Studies Diabetes Complications - blood Diabetes Complications - diagnostic imaging Diabetes Complications - physiopathology Diastole - physiology Dyslipidemias - blood Dyslipidemias - complications Dyslipidemias - diagnostic imaging Dyslipidemias - physiopathology Echocardiography Female Heart Ventricles - diagnostic imaging high-sensitive CRP Humans Hypertension - blood Hypertension - complications Hypertension - diagnostic imaging Hypertension - physiopathology left ventricular diastolic dysfunction left ventricular hypertrophy Male Middle Aged Risk Factors Ventricular Function, Left - physiology Young Adult |
| title | Association between High-Sensitivity C-Reactive Protein and Left Ventricular Diastolic Function Assessed by Echocardiography in Patients with Cardiovascular Risk Factors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T18%3A53%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20High-Sensitivity%20C-Reactive%20Protein%20and%20Left%20Ventricular%20Diastolic%20Function%20Assessed%20by%20Echocardiography%20in%20Patients%20with%20Cardiovascular%20Risk%20Factors&rft.jtitle=The%20Tohoku%20Journal%20of%20Experimental%20Medicine&rft.au=Masugata,%20Hisashi&rft.date=2011-04-01&rft.volume=223&rft.issue=4&rft.spage=263&rft.epage=268&rft.pages=263-268&rft.issn=0040-8727&rft.eissn=1349-3329&rft_id=info:doi/10.1620/tjem.223.263&rft_dat=%3Cproquest_cross%3E858287183%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=858287183&rft_id=info:pmid/21422746&rfr_iscdi=true |