A subset of breast cancer predisposes to brain metastasis
This study evaluated the expression of biological markers of breast cancers with brain metastases. Eighteen paired tumors were assessed, with 42 non-brain-metastasizing breast cancers that were stained with ER, PR, HER2, CK5/6, p63, and Ki67, and were also classified into intrinsic subtypes. The exp...
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| Veröffentlicht in: | Medical molecular morphology 2011-03, Vol.44 (1), p.15-20 |
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| creator | Shao, Mu-min Liu, Jun Vong, Joaquim S. Niu, Yun Germin, Barbara Tang, Ping Chan, Anthony W.H. Lui, Philip C.W. Law, Bonita K.B. Tan, Puay-Hoon Tse, Gary M. |
| description | This study evaluated the expression of biological markers of breast cancers with brain metastases. Eighteen paired tumors were assessed, with 42 non-brain-metastasizing breast cancers that were stained with ER, PR, HER2, CK5/6, p63, and Ki67, and were also classified into intrinsic subtypes. The expression patterns between the breast tumors with brain metastases were compared to the brain metastases and the controls. Breast cancers with brain metastases were of higher grade and showed higher incidence of lymph node metastases at initial diagnosis and higher EGFR, p63, and Ki67 expression. In the group of breast cancers with brain metastases, the brain metastases showed higher HER2, CK5/6, and Ki67 expression compared to the breast primaries. There was also a higher incidence of basal subtype and a lower incidence of luminal subtype. When tumors metastasized, changes in hormonal receptor (22%) and HER2 (6%) status were observed. We concluded that breast cancers with higher grade, lymph node involvement at diagnosis, high EGFR, p63, and Ki67 expression, and of basal subtype were at higher risk for brain metastases, and that both hormonal receptors and HER2 status may change in brain metastases. |
| doi_str_mv | 10.1007/s00795-010-0495-2 |
| format | Article |
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Eighteen paired tumors were assessed, with 42 non-brain-metastasizing breast cancers that were stained with ER, PR, HER2, CK5/6, p63, and Ki67, and were also classified into intrinsic subtypes. The expression patterns between the breast tumors with brain metastases were compared to the brain metastases and the controls. Breast cancers with brain metastases were of higher grade and showed higher incidence of lymph node metastases at initial diagnosis and higher EGFR, p63, and Ki67 expression. In the group of breast cancers with brain metastases, the brain metastases showed higher HER2, CK5/6, and Ki67 expression compared to the breast primaries. There was also a higher incidence of basal subtype and a lower incidence of luminal subtype. When tumors metastasized, changes in hormonal receptor (22%) and HER2 (6%) status were observed. We concluded that breast cancers with higher grade, lymph node involvement at diagnosis, high EGFR, p63, and Ki67 expression, and of basal subtype were at higher risk for brain metastases, and that both hormonal receptors and HER2 status may change in brain metastases.</description><identifier>ISSN: 1860-1480</identifier><identifier>EISSN: 1860-1499</identifier><identifier>DOI: 10.1007/s00795-010-0495-2</identifier><identifier>PMID: 21424932</identifier><identifier>CODEN: MELMEJ</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Adenocarcinoma, Mucinous - metabolism ; Adenocarcinoma, Mucinous - secondary ; Adult ; Aged ; Anatomy ; Biomarkers, Tumor - metabolism ; Brain ; Brain Neoplasms - metabolism ; Brain Neoplasms - secondary ; Breast cancer ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - metabolism ; Carcinoma, Ductal, Breast - secondary ; Carcinoma, Lobular - metabolism ; Carcinoma, Lobular - secondary ; Female ; Humans ; Keratin-5 - metabolism ; Keratin-6 - metabolism ; Ki-67 Antigen - metabolism ; Lymphatic Metastasis ; Medicine ; Medicine & Public Health ; Membrane Proteins - metabolism ; Metastasis ; Middle Aged ; Molecular Medicine ; Original Paper ; Pathology ; Receptor, Epidermal Growth Factor - metabolism ; Receptor, ErbB-2 - metabolism ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism</subject><ispartof>Medical molecular morphology, 2011-03, Vol.44 (1), p.15-20</ispartof><rights>The Japanese Society for Clinical Molecular Morphology 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-8c6a35f5f471d8669fd3c100532ec9666e32882bf5ed3906cc9fe466395f70d23</citedby><cites>FETCH-LOGICAL-c423t-8c6a35f5f471d8669fd3c100532ec9666e32882bf5ed3906cc9fe466395f70d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00795-010-0495-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00795-010-0495-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21424932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shao, Mu-min</creatorcontrib><creatorcontrib>Liu, Jun</creatorcontrib><creatorcontrib>Vong, Joaquim S.</creatorcontrib><creatorcontrib>Niu, Yun</creatorcontrib><creatorcontrib>Germin, Barbara</creatorcontrib><creatorcontrib>Tang, Ping</creatorcontrib><creatorcontrib>Chan, Anthony W.H.</creatorcontrib><creatorcontrib>Lui, Philip C.W.</creatorcontrib><creatorcontrib>Law, Bonita K.B.</creatorcontrib><creatorcontrib>Tan, Puay-Hoon</creatorcontrib><creatorcontrib>Tse, Gary M.</creatorcontrib><title>A subset of breast cancer predisposes to brain metastasis</title><title>Medical molecular morphology</title><addtitle>Med Mol Morphol</addtitle><addtitle>Med Mol Morphol</addtitle><description>This study evaluated the expression of biological markers of breast cancers with brain metastases. Eighteen paired tumors were assessed, with 42 non-brain-metastasizing breast cancers that were stained with ER, PR, HER2, CK5/6, p63, and Ki67, and were also classified into intrinsic subtypes. The expression patterns between the breast tumors with brain metastases were compared to the brain metastases and the controls. Breast cancers with brain metastases were of higher grade and showed higher incidence of lymph node metastases at initial diagnosis and higher EGFR, p63, and Ki67 expression. In the group of breast cancers with brain metastases, the brain metastases showed higher HER2, CK5/6, and Ki67 expression compared to the breast primaries. There was also a higher incidence of basal subtype and a lower incidence of luminal subtype. When tumors metastasized, changes in hormonal receptor (22%) and HER2 (6%) status were observed. We concluded that breast cancers with higher grade, lymph node involvement at diagnosis, high EGFR, p63, and Ki67 expression, and of basal subtype were at higher risk for brain metastases, and that both hormonal receptors and HER2 status may change in brain metastases.</description><subject>Adenocarcinoma, Mucinous - metabolism</subject><subject>Adenocarcinoma, Mucinous - secondary</subject><subject>Adult</subject><subject>Aged</subject><subject>Anatomy</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Brain</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - secondary</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Ductal, Breast - metabolism</subject><subject>Carcinoma, Ductal, Breast - secondary</subject><subject>Carcinoma, Lobular - metabolism</subject><subject>Carcinoma, Lobular - secondary</subject><subject>Female</subject><subject>Humans</subject><subject>Keratin-5 - metabolism</subject><subject>Keratin-6 - metabolism</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Lymphatic Metastasis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Membrane Proteins - metabolism</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Receptor, Epidermal Growth Factor - metabolism</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><issn>1860-1480</issn><issn>1860-1499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1LxDAURYMojo7-ADdS3Liq5rvJchj8ggE3ug5t-iIdpu2Y1y7892boOILgJnnwTm4uh5ArRu8YpcU9psOqnDKaU5kGfkTOmNE0Z9La48Ns6IycI64pFYXm6pTMOJNcWsHPiF1kOFYIQ9aHrIpQ4pD5svMQs22EusFtj4DZ0Kdl2XRZC0NCSmzwgpyEcoNwub_n5P3x4W35nK9en16Wi1XuJRdDbrwuhQoqyILVRmsbauFTeyU4eKu1BsGN4VVQUAtLtfc2gNRaWBUKWnMxJ7dT7jb2nyPg4NoGPWw2ZQf9iM4ow40orEzkzR9y3Y-xS-USVFirrNEJYhPkY48YIbhtbNoyfjlG3c6qm6y6ZNXtrLpdhet98Fi1UB9e_GhMAJ8ATKvuA-Lvz_-nfgPeP4A-</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Shao, Mu-min</creator><creator>Liu, Jun</creator><creator>Vong, Joaquim S.</creator><creator>Niu, Yun</creator><creator>Germin, Barbara</creator><creator>Tang, Ping</creator><creator>Chan, Anthony W.H.</creator><creator>Lui, Philip C.W.</creator><creator>Law, Bonita K.B.</creator><creator>Tan, Puay-Hoon</creator><creator>Tse, Gary M.</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110301</creationdate><title>A subset of breast cancer predisposes to brain metastasis</title><author>Shao, Mu-min ; Liu, Jun ; Vong, Joaquim S. ; Niu, Yun ; Germin, Barbara ; Tang, Ping ; Chan, Anthony W.H. ; Lui, Philip C.W. ; Law, Bonita K.B. ; Tan, Puay-Hoon ; Tse, Gary M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-8c6a35f5f471d8669fd3c100532ec9666e32882bf5ed3906cc9fe466395f70d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adenocarcinoma, Mucinous - 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Academic</collection><jtitle>Medical molecular morphology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shao, Mu-min</au><au>Liu, Jun</au><au>Vong, Joaquim S.</au><au>Niu, Yun</au><au>Germin, Barbara</au><au>Tang, Ping</au><au>Chan, Anthony W.H.</au><au>Lui, Philip C.W.</au><au>Law, Bonita K.B.</au><au>Tan, Puay-Hoon</au><au>Tse, Gary M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A subset of breast cancer predisposes to brain metastasis</atitle><jtitle>Medical molecular morphology</jtitle><stitle>Med Mol Morphol</stitle><addtitle>Med Mol Morphol</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>44</volume><issue>1</issue><spage>15</spage><epage>20</epage><pages>15-20</pages><issn>1860-1480</issn><eissn>1860-1499</eissn><coden>MELMEJ</coden><abstract>This study evaluated the expression of biological markers of breast cancers with brain metastases. Eighteen paired tumors were assessed, with 42 non-brain-metastasizing breast cancers that were stained with ER, PR, HER2, CK5/6, p63, and Ki67, and were also classified into intrinsic subtypes. The expression patterns between the breast tumors with brain metastases were compared to the brain metastases and the controls. Breast cancers with brain metastases were of higher grade and showed higher incidence of lymph node metastases at initial diagnosis and higher EGFR, p63, and Ki67 expression. In the group of breast cancers with brain metastases, the brain metastases showed higher HER2, CK5/6, and Ki67 expression compared to the breast primaries. There was also a higher incidence of basal subtype and a lower incidence of luminal subtype. When tumors metastasized, changes in hormonal receptor (22%) and HER2 (6%) status were observed. We concluded that breast cancers with higher grade, lymph node involvement at diagnosis, high EGFR, p63, and Ki67 expression, and of basal subtype were at higher risk for brain metastases, and that both hormonal receptors and HER2 status may change in brain metastases.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>21424932</pmid><doi>10.1007/s00795-010-0495-2</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenocarcinoma, Mucinous - metabolism Adenocarcinoma, Mucinous - secondary Adult Aged Anatomy Biomarkers, Tumor - metabolism Brain Brain Neoplasms - metabolism Brain Neoplasms - secondary Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - secondary Carcinoma, Lobular - metabolism Carcinoma, Lobular - secondary Female Humans Keratin-5 - metabolism Keratin-6 - metabolism Ki-67 Antigen - metabolism Lymphatic Metastasis Medicine Medicine & Public Health Membrane Proteins - metabolism Metastasis Middle Aged Molecular Medicine Original Paper Pathology Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism |
| title | A subset of breast cancer predisposes to brain metastasis |
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