Aerosol drug delivery: developments in device design and clinical use
Aerosolised drugs are prescribed for use in a range of inhaler devices and systems. Delivering drugs by inhalation requires a formulation that can be successfully aerosolised and a delivery system that produces a useful aerosol of the drug; the particles or droplets need to be of sufficient size and...
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| Veröffentlicht in: | The Lancet (British edition) 2011-03, Vol.377 (9770), p.1032-1045 |
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| creator | Dolovich, Myrna B, Prof Dhand, Rajiv, Prof |
| description | Aerosolised drugs are prescribed for use in a range of inhaler devices and systems. Delivering drugs by inhalation requires a formulation that can be successfully aerosolised and a delivery system that produces a useful aerosol of the drug; the particles or droplets need to be of sufficient size and mass to be carried to the distal lung or deposited on proximal airways to give rise to a therapeutic effect. Patients and caregivers must use and maintain these aerosol drug delivery devices correctly. In recent years, several technical innovations have led to aerosol drug delivery devices with efficient drug delivery and with novel features that take into account factors such as dose tracking, portability, materials of manufacture, breath actuation, the interface with the patient, combination therapies, and systemic delivery. These changes have improved performance in all four categories of devices: metered dose inhalers, spacers and holding chambers, dry powder inhalers, and nebulisers. Additionally, several therapies usually given by injection are now prescribed as aerosols for use in a range of drug delivery devices. In this Review, we discuss recent developments in the design and clinical use of aerosol devices over the past 10–15 years with an emphasis on the treatment of respiratory disorders. |
| doi_str_mv | 10.1016/S0140-6736(10)60926-9 |
| format | Article |
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Delivering drugs by inhalation requires a formulation that can be successfully aerosolised and a delivery system that produces a useful aerosol of the drug; the particles or droplets need to be of sufficient size and mass to be carried to the distal lung or deposited on proximal airways to give rise to a therapeutic effect. Patients and caregivers must use and maintain these aerosol drug delivery devices correctly. In recent years, several technical innovations have led to aerosol drug delivery devices with efficient drug delivery and with novel features that take into account factors such as dose tracking, portability, materials of manufacture, breath actuation, the interface with the patient, combination therapies, and systemic delivery. These changes have improved performance in all four categories of devices: metered dose inhalers, spacers and holding chambers, dry powder inhalers, and nebulisers. Additionally, several therapies usually given by injection are now prescribed as aerosols for use in a range of drug delivery devices. 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Delivering drugs by inhalation requires a formulation that can be successfully aerosolised and a delivery system that produces a useful aerosol of the drug; the particles or droplets need to be of sufficient size and mass to be carried to the distal lung or deposited on proximal airways to give rise to a therapeutic effect. Patients and caregivers must use and maintain these aerosol drug delivery devices correctly. In recent years, several technical innovations have led to aerosol drug delivery devices with efficient drug delivery and with novel features that take into account factors such as dose tracking, portability, materials of manufacture, breath actuation, the interface with the patient, combination therapies, and systemic delivery. These changes have improved performance in all four categories of devices: metered dose inhalers, spacers and holding chambers, dry powder inhalers, and nebulisers. Additionally, several therapies usually given by injection are now prescribed as aerosols for use in a range of drug delivery devices. In this Review, we discuss recent developments in the design and clinical use of aerosol devices over the past 10–15 years with an emphasis on the treatment of respiratory disorders.</description><subject>Administration, Inhalation</subject><subject>Aerosols</subject><subject>Aerosols - administration & dosage</subject><subject>Atoms & subatomic particles</subject><subject>Biological and medical sciences</subject><subject>breathing</subject><subject>caregivers</subject><subject>Clinical medicine</subject><subject>Cyclosporine - administration & dosage</subject><subject>Deoxyribonucleic acid</subject><subject>Design</subject><subject>Development</subject><subject>Disease</subject><subject>DNA</subject><subject>droplets</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>Drug development</subject><subject>drugs</subject><subject>Equipment Design</subject><subject>Fees & charges</subject><subject>General aspects</subject><subject>Generic products</subject><subject>Genetic Therapy - methods</subject><subject>Helium - administration & dosage</subject><subject>Humans</subject><subject>Iloprost - administration & dosage</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Inhalation</subject><subject>Internal Medicine</subject><subject>Lung</subject><subject>manufacturing</subject><subject>Market entry</subject><subject>Medical sciences</subject><subject>Nebulizers and Vaporizers</subject><subject>Oxygen - administration & dosage</subject><subject>Particle Size</subject><subject>patients</subject><subject>Pharmaceutical industry</subject><subject>Powder</subject><subject>Respiration, Artificial</subject><subject>Respiratory therapy</subject><subject>Respiratory tract</subject><subject>respiratory tract diseases</subject><subject>Reviews</subject><subject>Spacer</subject><subject>Technological change</subject><subject>therapeutics</subject><subject>Vaccines - administration & 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Delivering drugs by inhalation requires a formulation that can be successfully aerosolised and a delivery system that produces a useful aerosol of the drug; the particles or droplets need to be of sufficient size and mass to be carried to the distal lung or deposited on proximal airways to give rise to a therapeutic effect. Patients and caregivers must use and maintain these aerosol drug delivery devices correctly. In recent years, several technical innovations have led to aerosol drug delivery devices with efficient drug delivery and with novel features that take into account factors such as dose tracking, portability, materials of manufacture, breath actuation, the interface with the patient, combination therapies, and systemic delivery. These changes have improved performance in all four categories of devices: metered dose inhalers, spacers and holding chambers, dry powder inhalers, and nebulisers. 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| subjects | Administration, Inhalation Aerosols Aerosols - administration & dosage Atoms & subatomic particles Biological and medical sciences breathing caregivers Clinical medicine Cyclosporine - administration & dosage Deoxyribonucleic acid Design Development Disease DNA droplets Drug delivery Drug Delivery Systems Drug development drugs Equipment Design Fees & charges General aspects Generic products Genetic Therapy - methods Helium - administration & dosage Humans Iloprost - administration & dosage Immunosuppressive Agents - administration & dosage Inhalation Internal Medicine Lung manufacturing Market entry Medical sciences Nebulizers and Vaporizers Oxygen - administration & dosage Particle Size patients Pharmaceutical industry Powder Respiration, Artificial Respiratory therapy Respiratory tract respiratory tract diseases Reviews Spacer Technological change therapeutics Vaccines - administration & dosage Vasodilator Agents - administration & dosage |
| title | Aerosol drug delivery: developments in device design and clinical use |
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