Pyoderma gangrenosum: an Indian perspective
Summary Background. Pyoderma gangrenosum (PG) is an uncommon, idiopathic, neutrophilic skin disease sometimes associated with systemic diseases. To our knowledge, there have been no case series of PG reported from India. Aim. To study the clinical features, associated systemic diseases and treatme...
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| Veröffentlicht in: | Clinical and experimental dermatology 2011-04, Vol.36 (3), p.242-247 |
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| container_title | Clinical and experimental dermatology |
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| creator | Bhat, R. M. Nandakishore, B. Sequeira, F. F. Sukumar, D. Kamath, G. H. Martis, J. Furtado, S. |
| description | Summary
Background. Pyoderma gangrenosum (PG) is an uncommon, idiopathic, neutrophilic skin disease sometimes associated with systemic diseases. To our knowledge, there have been no case series of PG reported from India.
Aim. To study the clinical features, associated systemic diseases and treatment methods in our case series.
Methods. In total, 18 cases of PG diagnosed at our institution in Mangalore were evaluated in a prospective study.
Results. Ulcerative PG was the most common variant, seen in all except one case. Paediatric patients constituted less than a quarter (27.77%) of the patients. Systemic diseases were associated with the disease in over half of the patients (55.55%). The pathergy test was positive in seven patients (38.88%), and all but one had associated systemic disease. Corticosteroids were mainly used for management.
Conclusions. PG is a rare disease in India, but paediatric PG cases were relatively common. Ulcerative PG was the commonest type, and over half of the patients had associated systemic diseases. There were a significant number of patients with associated systemic disease who had a positive pathergy test. |
| doi_str_mv | 10.1111/j.1365-2230.2010.03941.x |
| format | Article |
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Background. Pyoderma gangrenosum (PG) is an uncommon, idiopathic, neutrophilic skin disease sometimes associated with systemic diseases. To our knowledge, there have been no case series of PG reported from India.
Aim. To study the clinical features, associated systemic diseases and treatment methods in our case series.
Methods. In total, 18 cases of PG diagnosed at our institution in Mangalore were evaluated in a prospective study.
Results. Ulcerative PG was the most common variant, seen in all except one case. Paediatric patients constituted less than a quarter (27.77%) of the patients. Systemic diseases were associated with the disease in over half of the patients (55.55%). The pathergy test was positive in seven patients (38.88%), and all but one had associated systemic disease. Corticosteroids were mainly used for management.
Conclusions. PG is a rare disease in India, but paediatric PG cases were relatively common. Ulcerative PG was the commonest type, and over half of the patients had associated systemic diseases. There were a significant number of patients with associated systemic disease who had a positive pathergy test.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/j.1365-2230.2010.03941.x</identifier><identifier>PMID: 21070329</identifier><identifier>CODEN: CEDEDE</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Age Factors ; Arthritis - complications ; Biological and medical sciences ; Breast implants ; Child ; Child, Preschool ; Colitis, Ulcerative - complications ; Dermatology ; Disease ; Female ; Follow-Up Studies ; Glucocorticoids - therapeutic use ; Humans ; Immunosuppressive Agents - therapeutic use ; India ; Male ; Medical research ; Medical sciences ; Middle Aged ; Myeloproliferative Disorders - complications ; Prospective Studies ; Pyoderma Gangrenosum - complications ; Pyoderma Gangrenosum - diagnosis ; Pyoderma Gangrenosum - drug therapy ; Skin involvement in other diseases. Miscellaneous. General aspects ; Treatment Outcome ; Young Adult</subject><ispartof>Clinical and experimental dermatology, 2011-04, Vol.36 (3), p.242-247</ispartof><rights>The Author(s). CED © 2010 British Association of Dermatologists</rights><rights>2015 INIST-CNRS</rights><rights>The Author(s). CED © 2010 British Association of Dermatologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4151-10e18b994ecab00a7fa3059e90569d0281b1a8bc46cd4d3a9da0631eca809ff33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24030834$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21070329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhat, R. M.</creatorcontrib><creatorcontrib>Nandakishore, B.</creatorcontrib><creatorcontrib>Sequeira, F. F.</creatorcontrib><creatorcontrib>Sukumar, D.</creatorcontrib><creatorcontrib>Kamath, G. H.</creatorcontrib><creatorcontrib>Martis, J.</creatorcontrib><creatorcontrib>Furtado, S.</creatorcontrib><title>Pyoderma gangrenosum: an Indian perspective</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Background. Pyoderma gangrenosum (PG) is an uncommon, idiopathic, neutrophilic skin disease sometimes associated with systemic diseases. To our knowledge, there have been no case series of PG reported from India.
Aim. To study the clinical features, associated systemic diseases and treatment methods in our case series.
Methods. In total, 18 cases of PG diagnosed at our institution in Mangalore were evaluated in a prospective study.
Results. Ulcerative PG was the most common variant, seen in all except one case. Paediatric patients constituted less than a quarter (27.77%) of the patients. Systemic diseases were associated with the disease in over half of the patients (55.55%). The pathergy test was positive in seven patients (38.88%), and all but one had associated systemic disease. Corticosteroids were mainly used for management.
Conclusions. PG is a rare disease in India, but paediatric PG cases were relatively common. Ulcerative PG was the commonest type, and over half of the patients had associated systemic diseases. There were a significant number of patients with associated systemic disease who had a positive pathergy test.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Arthritis - complications</subject><subject>Biological and medical sciences</subject><subject>Breast implants</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Colitis, Ulcerative - complications</subject><subject>Dermatology</subject><subject>Disease</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>India</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myeloproliferative Disorders - complications</subject><subject>Prospective Studies</subject><subject>Pyoderma Gangrenosum - complications</subject><subject>Pyoderma Gangrenosum - diagnosis</subject><subject>Pyoderma Gangrenosum - drug therapy</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV9P2zAUxS00BB3jK0yVpmkPU7prO05spD1shQFSBzwA7duVkzhVQv7Nbkb77efQrkjcl3vl-ztX1jmEjClMqK9v5YTySASMcZgw8K_AVUgn6wMy2i_ekRFwiINIcXlM3jtXAlBOY3FEjhmFGDhTI_L1btNmxtZ6vNTN0pqmdX19NtbN-LrJCt86Y11n0lXx13wgh7munDnd9RPy8OvifnoVzG4vr6c_ZkEaUkEDCobKRKnQpDoB0HGuOQhlFIhIZcAkTaiWSRpGaRZmXKtMQ8SppyWoPOf8hHzZ3u1s-6c3boV14VJTVboxbe9QCskk47Hy5Kc3ZNn2tvGfQyqYEixmwDz1cUf1SW0y7GxRa7vB_y544PMO0C7VVW51kxbulQu9kZKHnvu-5Z6Lymz2ewo4pIIlDubjYD4OqeBLKrjG6cX5MHl9sNUXbmXWe722TxjFPBY4v7nExe_F4_3jzzkq_g-oRYxQ</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Bhat, R. M.</creator><creator>Nandakishore, B.</creator><creator>Sequeira, F. F.</creator><creator>Sukumar, D.</creator><creator>Kamath, G. H.</creator><creator>Martis, J.</creator><creator>Furtado, S.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Pyoderma gangrenosum: an Indian perspective</title><author>Bhat, R. M. ; Nandakishore, B. ; Sequeira, F. F. ; Sukumar, D. ; Kamath, G. H. ; Martis, J. ; Furtado, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4151-10e18b994ecab00a7fa3059e90569d0281b1a8bc46cd4d3a9da0631eca809ff33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Arthritis - complications</topic><topic>Biological and medical sciences</topic><topic>Breast implants</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Colitis, Ulcerative - complications</topic><topic>Dermatology</topic><topic>Disease</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>India</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myeloproliferative Disorders - complications</topic><topic>Prospective Studies</topic><topic>Pyoderma Gangrenosum - complications</topic><topic>Pyoderma Gangrenosum - diagnosis</topic><topic>Pyoderma Gangrenosum - drug therapy</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhat, R. M.</creatorcontrib><creatorcontrib>Nandakishore, B.</creatorcontrib><creatorcontrib>Sequeira, F. F.</creatorcontrib><creatorcontrib>Sukumar, D.</creatorcontrib><creatorcontrib>Kamath, G. H.</creatorcontrib><creatorcontrib>Martis, J.</creatorcontrib><creatorcontrib>Furtado, S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhat, R. M.</au><au>Nandakishore, B.</au><au>Sequeira, F. F.</au><au>Sukumar, D.</au><au>Kamath, G. H.</au><au>Martis, J.</au><au>Furtado, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pyoderma gangrenosum: an Indian perspective</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2011-04</date><risdate>2011</risdate><volume>36</volume><issue>3</issue><spage>242</spage><epage>247</epage><pages>242-247</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><coden>CEDEDE</coden><abstract>Summary
Background. Pyoderma gangrenosum (PG) is an uncommon, idiopathic, neutrophilic skin disease sometimes associated with systemic diseases. To our knowledge, there have been no case series of PG reported from India.
Aim. To study the clinical features, associated systemic diseases and treatment methods in our case series.
Methods. In total, 18 cases of PG diagnosed at our institution in Mangalore were evaluated in a prospective study.
Results. Ulcerative PG was the most common variant, seen in all except one case. Paediatric patients constituted less than a quarter (27.77%) of the patients. Systemic diseases were associated with the disease in over half of the patients (55.55%). The pathergy test was positive in seven patients (38.88%), and all but one had associated systemic disease. Corticosteroids were mainly used for management.
Conclusions. PG is a rare disease in India, but paediatric PG cases were relatively common. Ulcerative PG was the commonest type, and over half of the patients had associated systemic diseases. There were a significant number of patients with associated systemic disease who had a positive pathergy test.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21070329</pmid><doi>10.1111/j.1365-2230.2010.03941.x</doi><tpages>6</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Age Factors Arthritis - complications Biological and medical sciences Breast implants Child Child, Preschool Colitis, Ulcerative - complications Dermatology Disease Female Follow-Up Studies Glucocorticoids - therapeutic use Humans Immunosuppressive Agents - therapeutic use India Male Medical research Medical sciences Middle Aged Myeloproliferative Disorders - complications Prospective Studies Pyoderma Gangrenosum - complications Pyoderma Gangrenosum - diagnosis Pyoderma Gangrenosum - drug therapy Skin involvement in other diseases. Miscellaneous. General aspects Treatment Outcome Young Adult |
| title | Pyoderma gangrenosum: an Indian perspective |
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