Detecting and defining the anatomic extent of large nerve perineural spread of malignancy: Comparing "targeted" MRI with the histologic findings following surgery
Background. The accurate preoperative identification of the extent of perineural spread (PNS) of malignancy along a cranial nerve is vital to the design of an appropriate surgical resection. Our purpose was to determine the sensitivity of targeted MRI in predicting the presence of disease and the an...
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| Veröffentlicht in: | Head & neck 2011-04, Vol.33 (4), p.469-475 |
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| creator | Gandhi, M. R. Panizza, B. Kennedy, D. |
| description | Background.
The accurate preoperative identification of the extent of perineural spread (PNS) of malignancy along a cranial nerve is vital to the design of an appropriate surgical resection. Our purpose was to determine the sensitivity of targeted MRI in predicting the presence of disease and the anatomic extent of spread when compared with histologic findings.
Methods.
A retrospective review was performed of 25 patients with PNS who had targeted MRI and surgery to excise perineural tumor (2002–2008).
Results.
MRI detected PNS in 30 of 30 nerves (100%) with 1 false positive. MRI correctly identified the extent of spread based on histology in 25 of 30 nerves (83.3%). In 4 of 30 cases (13.3%) MRI underestimated the extent of spread proximal to the Gasserian ganglion that, if diagnosed preoperatively, may have deemed the patient inoperable.
Conclusions.
MRI demonstrated the presence and anatomic extent of PNS in the majority of cases. MRI may underestimate microscopic spread proximal to the Gasserian ganglion. © 2010 Wiley Periodicals, Inc. Head Neck, 2011 |
| doi_str_mv | 10.1002/hed.21470 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_858282145</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1323805508</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4930-9af0e20e15f5e74f2b7068cf8c894de24435753ae8a6b4a01b64e6a65fdb434d3</originalsourceid><addsrcrecordid>eNqFkUtv1DAUhSMEoqWw4A8gqxICFmkdPxIPO5jpCxWQqiKWlpNczxicONgepvN3-KV15gErYGX76jvn6Ppk2fMCnxQYk9MFtCekYBV-kB0WeFLlmLLq4XhnNKe4YgfZkxC-YYxpycjj7IDgknEi-GH2awYRmmj6OVJ9i1rQph8fcQFpoKLrTIPgLkIfkdPIKj8H1IP_CWgAb3pYemVRGDyodgQ6Zc28V32zfoumrhuUH92O46iL0B6jjzdXaGXiYpOwMCE66-YpI-W2CQ1IO2vdalSFZRL59dPskVY2wLPdeZR9OT-7nV7m158vrqbvrvOGTSjOJ0pjIBgKrjlUTJO6wqVotGjEhLVAGKO84lSBUGXNFC7qkkGpSq7bmlHW0qPs1dZ38O7HEkKUnQkNWKt6cMsgBRdEpG_miXz9T7KghArMORb_RxNZkDLBCX2zRRvvQvCg5eBNp_xaFliOPcvUs9z0nNgXO9tl3aXpntwXm4CXO0CFRlntUyUm_OEYJoxsVjndcitjYf33RHl5NttH51tF6g7ufiuU_y7LilZcfv10Iafv2Q2ZfSjkLb0HVzjPHw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1238126055</pqid></control><display><type>article</type><title>Detecting and defining the anatomic extent of large nerve perineural spread of malignancy: Comparing "targeted" MRI with the histologic findings following surgery</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Gandhi, M. R. ; Panizza, B. ; Kennedy, D.</creator><creatorcontrib>Gandhi, M. R. ; Panizza, B. ; Kennedy, D.</creatorcontrib><description>Background.
The accurate preoperative identification of the extent of perineural spread (PNS) of malignancy along a cranial nerve is vital to the design of an appropriate surgical resection. Our purpose was to determine the sensitivity of targeted MRI in predicting the presence of disease and the anatomic extent of spread when compared with histologic findings.
Methods.
A retrospective review was performed of 25 patients with PNS who had targeted MRI and surgery to excise perineural tumor (2002–2008).
Results.
MRI detected PNS in 30 of 30 nerves (100%) with 1 false positive. MRI correctly identified the extent of spread based on histology in 25 of 30 nerves (83.3%). In 4 of 30 cases (13.3%) MRI underestimated the extent of spread proximal to the Gasserian ganglion that, if diagnosed preoperatively, may have deemed the patient inoperable.
Conclusions.
MRI demonstrated the presence and anatomic extent of PNS in the majority of cases. MRI may underestimate microscopic spread proximal to the Gasserian ganglion. © 2010 Wiley Periodicals, Inc. Head Neck, 2011</description><identifier>ISSN: 1043-3074</identifier><identifier>ISSN: 1097-0347</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.21470</identifier><identifier>PMID: 20645285</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Cranial Nerve Neoplasms - diagnosis ; Cranial Nerve Neoplasms - pathology ; Cranial nerves ; facial ; Facial Nerve - pathology ; Facial Nerve - surgery ; Female ; Head ; head and neck neoplasms ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - surgery ; Humans ; Magnetic Resonance Imaging ; Male ; Malignancy ; Medical sciences ; Middle Aged ; MRI ; Neck ; Neoplasm Invasiveness ; nerves ; nerves, facial ; nerves, trigeminal ; Otorhinolaryngology. Stomatology ; perineural spread ; Skin Neoplasms - pathology ; Skin Neoplasms - surgery ; Surgery ; trigeminal ; Trigeminal Nerve - pathology ; Trigeminal Nerve - surgery ; Tumors</subject><ispartof>Head & neck, 2011-04, Vol.33 (4), p.469-475</ispartof><rights>Copyright © 2010 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4930-9af0e20e15f5e74f2b7068cf8c894de24435753ae8a6b4a01b64e6a65fdb434d3</citedby><cites>FETCH-LOGICAL-c4930-9af0e20e15f5e74f2b7068cf8c894de24435753ae8a6b4a01b64e6a65fdb434d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.21470$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.21470$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24024245$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20645285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gandhi, M. R.</creatorcontrib><creatorcontrib>Panizza, B.</creatorcontrib><creatorcontrib>Kennedy, D.</creatorcontrib><title>Detecting and defining the anatomic extent of large nerve perineural spread of malignancy: Comparing "targeted" MRI with the histologic findings following surgery</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background.
The accurate preoperative identification of the extent of perineural spread (PNS) of malignancy along a cranial nerve is vital to the design of an appropriate surgical resection. Our purpose was to determine the sensitivity of targeted MRI in predicting the presence of disease and the anatomic extent of spread when compared with histologic findings.
Methods.
A retrospective review was performed of 25 patients with PNS who had targeted MRI and surgery to excise perineural tumor (2002–2008).
Results.
MRI detected PNS in 30 of 30 nerves (100%) with 1 false positive. MRI correctly identified the extent of spread based on histology in 25 of 30 nerves (83.3%). In 4 of 30 cases (13.3%) MRI underestimated the extent of spread proximal to the Gasserian ganglion that, if diagnosed preoperatively, may have deemed the patient inoperable.
Conclusions.
MRI demonstrated the presence and anatomic extent of PNS in the majority of cases. MRI may underestimate microscopic spread proximal to the Gasserian ganglion. © 2010 Wiley Periodicals, Inc. Head Neck, 2011</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Cranial Nerve Neoplasms - diagnosis</subject><subject>Cranial Nerve Neoplasms - pathology</subject><subject>Cranial nerves</subject><subject>facial</subject><subject>Facial Nerve - pathology</subject><subject>Facial Nerve - surgery</subject><subject>Female</subject><subject>Head</subject><subject>head and neck neoplasms</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - surgery</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Neck</subject><subject>Neoplasm Invasiveness</subject><subject>nerves</subject><subject>nerves, facial</subject><subject>nerves, trigeminal</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>perineural spread</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - surgery</subject><subject>Surgery</subject><subject>trigeminal</subject><subject>Trigeminal Nerve - pathology</subject><subject>Trigeminal Nerve - surgery</subject><subject>Tumors</subject><issn>1043-3074</issn><issn>1097-0347</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhSMEoqWw4A8gqxICFmkdPxIPO5jpCxWQqiKWlpNczxicONgepvN3-KV15gErYGX76jvn6Ppk2fMCnxQYk9MFtCekYBV-kB0WeFLlmLLq4XhnNKe4YgfZkxC-YYxpycjj7IDgknEi-GH2awYRmmj6OVJ9i1rQph8fcQFpoKLrTIPgLkIfkdPIKj8H1IP_CWgAb3pYemVRGDyodgQ6Zc28V32zfoumrhuUH92O46iL0B6jjzdXaGXiYpOwMCE66-YpI-W2CQ1IO2vdalSFZRL59dPskVY2wLPdeZR9OT-7nV7m158vrqbvrvOGTSjOJ0pjIBgKrjlUTJO6wqVotGjEhLVAGKO84lSBUGXNFC7qkkGpSq7bmlHW0qPs1dZ38O7HEkKUnQkNWKt6cMsgBRdEpG_miXz9T7KghArMORb_RxNZkDLBCX2zRRvvQvCg5eBNp_xaFliOPcvUs9z0nNgXO9tl3aXpntwXm4CXO0CFRlntUyUm_OEYJoxsVjndcitjYf33RHl5NttH51tF6g7ufiuU_y7LilZcfv10Iafv2Q2ZfSjkLb0HVzjPHw</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Gandhi, M. R.</creator><creator>Panizza, B.</creator><creator>Kennedy, D.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Detecting and defining the anatomic extent of large nerve perineural spread of malignancy: Comparing "targeted" MRI with the histologic findings following surgery</title><author>Gandhi, M. R. ; Panizza, B. ; Kennedy, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4930-9af0e20e15f5e74f2b7068cf8c894de24435753ae8a6b4a01b64e6a65fdb434d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Cranial Nerve Neoplasms - diagnosis</topic><topic>Cranial Nerve Neoplasms - pathology</topic><topic>Cranial nerves</topic><topic>facial</topic><topic>Facial Nerve - pathology</topic><topic>Facial Nerve - surgery</topic><topic>Female</topic><topic>Head</topic><topic>head and neck neoplasms</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - surgery</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Malignancy</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Neck</topic><topic>Neoplasm Invasiveness</topic><topic>nerves</topic><topic>nerves, facial</topic><topic>nerves, trigeminal</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>perineural spread</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - surgery</topic><topic>Surgery</topic><topic>trigeminal</topic><topic>Trigeminal Nerve - pathology</topic><topic>Trigeminal Nerve - surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gandhi, M. R.</creatorcontrib><creatorcontrib>Panizza, B.</creatorcontrib><creatorcontrib>Kennedy, D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gandhi, M. R.</au><au>Panizza, B.</au><au>Kennedy, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detecting and defining the anatomic extent of large nerve perineural spread of malignancy: Comparing "targeted" MRI with the histologic findings following surgery</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2011-04</date><risdate>2011</risdate><volume>33</volume><issue>4</issue><spage>469</spage><epage>475</epage><pages>469-475</pages><issn>1043-3074</issn><issn>1097-0347</issn><eissn>1097-0347</eissn><abstract>Background.
The accurate preoperative identification of the extent of perineural spread (PNS) of malignancy along a cranial nerve is vital to the design of an appropriate surgical resection. Our purpose was to determine the sensitivity of targeted MRI in predicting the presence of disease and the anatomic extent of spread when compared with histologic findings.
Methods.
A retrospective review was performed of 25 patients with PNS who had targeted MRI and surgery to excise perineural tumor (2002–2008).
Results.
MRI detected PNS in 30 of 30 nerves (100%) with 1 false positive. MRI correctly identified the extent of spread based on histology in 25 of 30 nerves (83.3%). In 4 of 30 cases (13.3%) MRI underestimated the extent of spread proximal to the Gasserian ganglion that, if diagnosed preoperatively, may have deemed the patient inoperable.
Conclusions.
MRI demonstrated the presence and anatomic extent of PNS in the majority of cases. MRI may underestimate microscopic spread proximal to the Gasserian ganglion. © 2010 Wiley Periodicals, Inc. Head Neck, 2011</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20645285</pmid><doi>10.1002/hed.21470</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Cranial Nerve Neoplasms - diagnosis Cranial Nerve Neoplasms - pathology Cranial nerves facial Facial Nerve - pathology Facial Nerve - surgery Female Head head and neck neoplasms Head and Neck Neoplasms - pathology Head and Neck Neoplasms - surgery Humans Magnetic Resonance Imaging Male Malignancy Medical sciences Middle Aged MRI Neck Neoplasm Invasiveness nerves nerves, facial nerves, trigeminal Otorhinolaryngology. Stomatology perineural spread Skin Neoplasms - pathology Skin Neoplasms - surgery Surgery trigeminal Trigeminal Nerve - pathology Trigeminal Nerve - surgery Tumors |
| title | Detecting and defining the anatomic extent of large nerve perineural spread of malignancy: Comparing "targeted" MRI with the histologic findings following surgery |
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