Differences of immunophenotypic markers and signaling molecules between adenocarcinomas of gastric cardia and distal stomach
Summary During the past decades, the subsites of gastric carcinoma underwent significant changes. The incidence of the adenocarcinoma at distal stomach has been decreased, whereas cardiac adenocarcinoma remained increasing in many countries. The aim of this study was to investigate the differences b...
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| Veröffentlicht in: | Human pathology 2011-04, Vol.42 (4), p.594-601 |
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| creator | Xue, Liying, MD Zhang, Xianghong, MD Li, Yuehong, MD Yang, Haiyan, MS Li, Xuemin, BS Mi, Jianmin, BS Wang, Hengshu, BS Wang, Junling, BS Yan, Xia, BS |
| description | Summary During the past decades, the subsites of gastric carcinoma underwent significant changes. The incidence of the adenocarcinoma at distal stomach has been decreased, whereas cardiac adenocarcinoma remained increasing in many countries. The aim of this study was to investigate the differences between gastric cardiac and distal adenocarcinomas. We detected expressions of cytokeratins (cytokeratins 7, 14, 19, and 20) and mucins (mucins 1, 2, and 5AC) by immunohistochemistry and signaling molecules (p38, mitogen-activated protein kinase-interacting kinase 1 (MNK1), extracellular signal-regulated kinase, Jun N-terminal kinase, and phosphoinositide 3 kinase) by reverse transcription–polymerase chain reaction in both groups. The incidence of mucin 2 expression was lower in total (50.0%) and advanced-stage cases (52.0%) with cardiac adenocarcinomas than those in distal cases with total (70.2%) and advanced stage (71.4%), respectively. However, the staining for cytokeratin 14 was also significantly higher in total or advanced-stage tumors from the cardia. Our data showed no significant difference of cytokeratin 7/cytokeratin 20 pattern between 2 groups, but cytokeratin 20 expression was significantly higher in advanced-stage carcinomas of the cardia (58.7%) than in distal ones with advanced stage (38.3%). A multivariate analysis demonstrated different relationships between immunophenotypic markers and pathologic parameters in adenocarcinomas of the cardia and distal stomach. Moreover, significantly lower expressions of MNK1 and p38 in cardiac tumors were also detected. In summary, we found significant differences in patterns of immunophenotypic markers and expressions of signaling molecules between the 2 groups. It is indicated that adenocarcinoma of the cardia was different in histotype and histologic origin from distal adenocarcinoma. The cardiac adenocarcinoma might be a special subtype or an independent entity of gastric carcinoma in China. |
| doi_str_mv | 10.1016/j.humpath.2010.06.015 |
| format | Article |
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The incidence of the adenocarcinoma at distal stomach has been decreased, whereas cardiac adenocarcinoma remained increasing in many countries. The aim of this study was to investigate the differences between gastric cardiac and distal adenocarcinomas. We detected expressions of cytokeratins (cytokeratins 7, 14, 19, and 20) and mucins (mucins 1, 2, and 5AC) by immunohistochemistry and signaling molecules (p38, mitogen-activated protein kinase-interacting kinase 1 (MNK1), extracellular signal-regulated kinase, Jun N-terminal kinase, and phosphoinositide 3 kinase) by reverse transcription–polymerase chain reaction in both groups. The incidence of mucin 2 expression was lower in total (50.0%) and advanced-stage cases (52.0%) with cardiac adenocarcinomas than those in distal cases with total (70.2%) and advanced stage (71.4%), respectively. However, the staining for cytokeratin 14 was also significantly higher in total or advanced-stage tumors from the cardia. Our data showed no significant difference of cytokeratin 7/cytokeratin 20 pattern between 2 groups, but cytokeratin 20 expression was significantly higher in advanced-stage carcinomas of the cardia (58.7%) than in distal ones with advanced stage (38.3%). A multivariate analysis demonstrated different relationships between immunophenotypic markers and pathologic parameters in adenocarcinomas of the cardia and distal stomach. Moreover, significantly lower expressions of MNK1 and p38 in cardiac tumors were also detected. In summary, we found significant differences in patterns of immunophenotypic markers and expressions of signaling molecules between the 2 groups. It is indicated that adenocarcinoma of the cardia was different in histotype and histologic origin from distal adenocarcinoma. The cardiac adenocarcinoma might be a special subtype or an independent entity of gastric carcinoma in China.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2010.06.015</identifier><identifier>PMID: 21146193</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adenocarcinoma - epidemiology ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Adenocarcinoma of distal stomach ; Adenocarcinoma of gastric cardia ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - metabolism ; Cancer ; Cardia - metabolism ; Cardia - pathology ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Keratin-20 - biosynthesis ; Keratin-7 - biosynthesis ; Kinases ; Medical sciences ; Molecular weight ; Mucins - biosynthesis ; Neoplasm Staging ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Phenotypic markers ; Polymerase chain reaction ; Pyloric Antrum - metabolism ; Pyloric Antrum - pathology ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction - physiology ; Signaling molecules ; Stomach Neoplasms - epidemiology ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Studies</subject><ispartof>Human pathology, 2011-04, Vol.42 (4), p.594-601</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-fed20a5a4313dccb8a22d806029ea3d6e5fcca0116aa81cea80163f095db23f23</citedby><cites>FETCH-LOGICAL-c543t-fed20a5a4313dccb8a22d806029ea3d6e5fcca0116aa81cea80163f095db23f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humpath.2010.06.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24066077$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21146193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xue, Liying, MD</creatorcontrib><creatorcontrib>Zhang, Xianghong, MD</creatorcontrib><creatorcontrib>Li, Yuehong, MD</creatorcontrib><creatorcontrib>Yang, Haiyan, MS</creatorcontrib><creatorcontrib>Li, Xuemin, BS</creatorcontrib><creatorcontrib>Mi, Jianmin, BS</creatorcontrib><creatorcontrib>Wang, Hengshu, BS</creatorcontrib><creatorcontrib>Wang, Junling, BS</creatorcontrib><creatorcontrib>Yan, Xia, BS</creatorcontrib><title>Differences of immunophenotypic markers and signaling molecules between adenocarcinomas of gastric cardia and distal stomach</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary During the past decades, the subsites of gastric carcinoma underwent significant changes. The incidence of the adenocarcinoma at distal stomach has been decreased, whereas cardiac adenocarcinoma remained increasing in many countries. The aim of this study was to investigate the differences between gastric cardiac and distal adenocarcinomas. We detected expressions of cytokeratins (cytokeratins 7, 14, 19, and 20) and mucins (mucins 1, 2, and 5AC) by immunohistochemistry and signaling molecules (p38, mitogen-activated protein kinase-interacting kinase 1 (MNK1), extracellular signal-regulated kinase, Jun N-terminal kinase, and phosphoinositide 3 kinase) by reverse transcription–polymerase chain reaction in both groups. The incidence of mucin 2 expression was lower in total (50.0%) and advanced-stage cases (52.0%) with cardiac adenocarcinomas than those in distal cases with total (70.2%) and advanced stage (71.4%), respectively. However, the staining for cytokeratin 14 was also significantly higher in total or advanced-stage tumors from the cardia. Our data showed no significant difference of cytokeratin 7/cytokeratin 20 pattern between 2 groups, but cytokeratin 20 expression was significantly higher in advanced-stage carcinomas of the cardia (58.7%) than in distal ones with advanced stage (38.3%). A multivariate analysis demonstrated different relationships between immunophenotypic markers and pathologic parameters in adenocarcinomas of the cardia and distal stomach. Moreover, significantly lower expressions of MNK1 and p38 in cardiac tumors were also detected. In summary, we found significant differences in patterns of immunophenotypic markers and expressions of signaling molecules between the 2 groups. It is indicated that adenocarcinoma of the cardia was different in histotype and histologic origin from distal adenocarcinoma. The cardiac adenocarcinoma might be a special subtype or an independent entity of gastric carcinoma in China.</description><subject>Adenocarcinoma - epidemiology</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma of distal stomach</subject><subject>Adenocarcinoma of gastric cardia</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Cardia - metabolism</subject><subject>Cardia - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Keratin-20 - biosynthesis</subject><subject>Keratin-7 - biosynthesis</subject><subject>Kinases</subject><subject>Medical sciences</subject><subject>Molecular weight</subject><subject>Mucins - biosynthesis</subject><subject>Neoplasm Staging</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Phenotypic markers</subject><subject>Polymerase chain reaction</subject><subject>Pyloric Antrum - metabolism</subject><subject>Pyloric Antrum - pathology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Signal Transduction - physiology</subject><subject>Signaling molecules</subject><subject>Stomach Neoplasms - epidemiology</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Studies</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2LFDEQhoMo7uzqT1AaRPbUYyXpZNIXRdZPWPCgnkNNUj2T2f4Yk25lwB9vemd0YS-eAsXzvqmqtxh7xmHJgetXu-V26vY4bpcCcg30Erh6wBZcSVEaWYuHbAFQ6dLw1eqMnae0A-BcVeoxOxOcV5rXcsF-vwtNQ5F6R6kYmiJ03dQP-y31w3jYB1d0GG8opgJ7X6Sw6bEN_abohpbc1GbNmsZfRH2BPkscRhf6ocNbrw2mMWaLXPUBbx18SCO2RRoz47ZP2KMG20RPT-8F-_7h_berT-X1l4-fr95el05Vciwb8gJQYSW59M6tDQrhDWgQNaH0mlTjHObhNKLhjtDkBckGauXXQjZCXrDLo-8-Dj8mSqPtQnLUttjTMCVrlBGGS6gy-eIeuRummIdOloOsTA1GrTKljpSLQ0qRGruPIS_qkCE7p2N39pSOndOxoG1OJ-uen9yndUf-n-pvHBl4eQIwOWybiL0L6Y6rQGtYzQ28OXKUt_YzULTJhTlDHyK50foh_LeV1_ccXA425E9v6EDpbmqbhAX7dT6l-ZI4AEihtfwDQ4DHdg</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Xue, Liying, MD</creator><creator>Zhang, Xianghong, MD</creator><creator>Li, Yuehong, MD</creator><creator>Yang, Haiyan, MS</creator><creator>Li, Xuemin, BS</creator><creator>Mi, Jianmin, BS</creator><creator>Wang, Hengshu, BS</creator><creator>Wang, Junling, BS</creator><creator>Yan, Xia, BS</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Differences of immunophenotypic markers and signaling molecules between adenocarcinomas of gastric cardia and distal stomach</title><author>Xue, Liying, MD ; Zhang, Xianghong, MD ; Li, Yuehong, MD ; Yang, Haiyan, MS ; Li, Xuemin, BS ; Mi, Jianmin, BS ; Wang, Hengshu, BS ; Wang, Junling, BS ; Yan, Xia, BS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-fed20a5a4313dccb8a22d806029ea3d6e5fcca0116aa81cea80163f095db23f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adenocarcinoma - epidemiology</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma of distal stomach</topic><topic>Adenocarcinoma of gastric cardia</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer</topic><topic>Cardia - metabolism</topic><topic>Cardia - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Keratin-20 - biosynthesis</topic><topic>Keratin-7 - biosynthesis</topic><topic>Kinases</topic><topic>Medical sciences</topic><topic>Molecular weight</topic><topic>Mucins - biosynthesis</topic><topic>Neoplasm Staging</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Phenotypic markers</topic><topic>Polymerase chain reaction</topic><topic>Pyloric Antrum - metabolism</topic><topic>Pyloric Antrum - pathology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Signal Transduction - physiology</topic><topic>Signaling molecules</topic><topic>Stomach Neoplasms - epidemiology</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xue, Liying, MD</creatorcontrib><creatorcontrib>Zhang, Xianghong, MD</creatorcontrib><creatorcontrib>Li, Yuehong, MD</creatorcontrib><creatorcontrib>Yang, Haiyan, MS</creatorcontrib><creatorcontrib>Li, Xuemin, BS</creatorcontrib><creatorcontrib>Mi, Jianmin, BS</creatorcontrib><creatorcontrib>Wang, Hengshu, BS</creatorcontrib><creatorcontrib>Wang, Junling, BS</creatorcontrib><creatorcontrib>Yan, Xia, BS</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xue, Liying, MD</au><au>Zhang, Xianghong, MD</au><au>Li, Yuehong, MD</au><au>Yang, Haiyan, MS</au><au>Li, Xuemin, BS</au><au>Mi, Jianmin, BS</au><au>Wang, Hengshu, BS</au><au>Wang, Junling, BS</au><au>Yan, Xia, BS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences of immunophenotypic markers and signaling molecules between adenocarcinomas of gastric cardia and distal stomach</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>42</volume><issue>4</issue><spage>594</spage><epage>601</epage><pages>594-601</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Summary During the past decades, the subsites of gastric carcinoma underwent significant changes. The incidence of the adenocarcinoma at distal stomach has been decreased, whereas cardiac adenocarcinoma remained increasing in many countries. The aim of this study was to investigate the differences between gastric cardiac and distal adenocarcinomas. We detected expressions of cytokeratins (cytokeratins 7, 14, 19, and 20) and mucins (mucins 1, 2, and 5AC) by immunohistochemistry and signaling molecules (p38, mitogen-activated protein kinase-interacting kinase 1 (MNK1), extracellular signal-regulated kinase, Jun N-terminal kinase, and phosphoinositide 3 kinase) by reverse transcription–polymerase chain reaction in both groups. The incidence of mucin 2 expression was lower in total (50.0%) and advanced-stage cases (52.0%) with cardiac adenocarcinomas than those in distal cases with total (70.2%) and advanced stage (71.4%), respectively. However, the staining for cytokeratin 14 was also significantly higher in total or advanced-stage tumors from the cardia. Our data showed no significant difference of cytokeratin 7/cytokeratin 20 pattern between 2 groups, but cytokeratin 20 expression was significantly higher in advanced-stage carcinomas of the cardia (58.7%) than in distal ones with advanced stage (38.3%). A multivariate analysis demonstrated different relationships between immunophenotypic markers and pathologic parameters in adenocarcinomas of the cardia and distal stomach. Moreover, significantly lower expressions of MNK1 and p38 in cardiac tumors were also detected. In summary, we found significant differences in patterns of immunophenotypic markers and expressions of signaling molecules between the 2 groups. It is indicated that adenocarcinoma of the cardia was different in histotype and histologic origin from distal adenocarcinoma. The cardiac adenocarcinoma might be a special subtype or an independent entity of gastric carcinoma in China.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21146193</pmid><doi>10.1016/j.humpath.2010.06.015</doi><tpages>8</tpages></addata></record> |
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| subjects | Adenocarcinoma - epidemiology Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma of distal stomach Adenocarcinoma of gastric cardia Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Cancer Cardia - metabolism Cardia - pathology Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Keratin-20 - biosynthesis Keratin-7 - biosynthesis Kinases Medical sciences Molecular weight Mucins - biosynthesis Neoplasm Staging Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phenotypic markers Polymerase chain reaction Pyloric Antrum - metabolism Pyloric Antrum - pathology Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - physiology Signaling molecules Stomach Neoplasms - epidemiology Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Studies |
| title | Differences of immunophenotypic markers and signaling molecules between adenocarcinomas of gastric cardia and distal stomach |
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