Hypophosphatemia in Kidney Transplant Recipients: Report of Acute Phosphate Nephropathy as a Complication of Therapy
Hypophosphatemia is a common complication after kidney transplant, affecting >90% of patients. However, no specific recommendations for phosphate repletion exist for transplant recipients. We report a case of a 70-year-old highly sensitized woman with end-stage renal disease caused by diabetic ne...
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| Veröffentlicht in: | American journal of kidney diseases 2011-04, Vol.57 (4), p.641-645 |
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| container_title | American journal of kidney diseases |
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| creator | Riella, Leonardo V., MD Rennke, Helmut G., MD Grafals, Monica, MD Chandraker, Anil, MD |
| description | Hypophosphatemia is a common complication after kidney transplant, affecting >90% of patients. However, no specific recommendations for phosphate repletion exist for transplant recipients. We report a case of a 70-year-old highly sensitized woman with end-stage renal disease caused by diabetic nephropathy who underwent deceased donor kidney transplant. Four weeks later, she was noted to have hypophosphatemia with undetectable serum phosphate levels, and she reported mild diarrhea. She was started on oral phosphate supplementation. On a routine visit 2 weeks later, she was found to have an acute increase in serum creatinine level and kidney biopsy was performed. We discuss the causes, management, and complications of hypophosphatemia in kidney transplant. |
| doi_str_mv | 10.1053/j.ajkd.2010.11.024 |
| format | Article |
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However, no specific recommendations for phosphate repletion exist for transplant recipients. We report a case of a 70-year-old highly sensitized woman with end-stage renal disease caused by diabetic nephropathy who underwent deceased donor kidney transplant. Four weeks later, she was noted to have hypophosphatemia with undetectable serum phosphate levels, and she reported mild diarrhea. She was started on oral phosphate supplementation. On a routine visit 2 weeks later, she was found to have an acute increase in serum creatinine level and kidney biopsy was performed. We discuss the causes, management, and complications of hypophosphatemia in kidney transplant.</description><identifier>ISSN: 0272-6386</identifier><identifier>EISSN: 1523-6838</identifier><identifier>DOI: 10.1053/j.ajkd.2010.11.024</identifier><identifier>PMID: 21333424</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acetates - therapeutic use ; Acute kidney injury ; Administration, Oral ; Aged ; Biological and medical sciences ; Biopsy ; Calcium Compounds - therapeutic use ; Creatinine - blood ; Endocrinopathies ; Female ; Humans ; hyperparathyroidism ; hypophosphatemia ; Hypophosphatemia - drug therapy ; Hypophosphatemia - etiology ; Kidney - pathology ; Kidney Failure, Chronic - surgery ; kidney transplant ; Kidney Transplantation - adverse effects ; Kidneys ; Medical sciences ; Nephrology ; Nephrology. Urinary tract diseases ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) ; phosphate ; Phosphates - administration & dosage ; Phosphates - adverse effects ; Phosphates - therapeutic use ; Renal Insufficiency - chemically induced ; Renal Insufficiency - diagnosis ; Renal Insufficiency - drug therapy ; Treatment Outcome ; Urinary system involvement in other diseases. Miscellaneous</subject><ispartof>American journal of kidney diseases, 2011-04, Vol.57 (4), p.641-645</ispartof><rights>National Kidney Foundation, Inc.</rights><rights>2011 National Kidney Foundation, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-eb52c8616ac704c293fe8b68a08aeecc733abe8b9b89a0a0bef841d71a3a3d0d3</citedby><cites>FETCH-LOGICAL-c506t-eb52c8616ac704c293fe8b68a08aeecc733abe8b9b89a0a0bef841d71a3a3d0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/j.ajkd.2010.11.024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24061978$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21333424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riella, Leonardo V., MD</creatorcontrib><creatorcontrib>Rennke, Helmut G., MD</creatorcontrib><creatorcontrib>Grafals, Monica, MD</creatorcontrib><creatorcontrib>Chandraker, Anil, MD</creatorcontrib><title>Hypophosphatemia in Kidney Transplant Recipients: Report of Acute Phosphate Nephropathy as a Complication of Therapy</title><title>American journal of kidney diseases</title><addtitle>Am J Kidney Dis</addtitle><description>Hypophosphatemia is a common complication after kidney transplant, affecting >90% of patients. However, no specific recommendations for phosphate repletion exist for transplant recipients. We report a case of a 70-year-old highly sensitized woman with end-stage renal disease caused by diabetic nephropathy who underwent deceased donor kidney transplant. Four weeks later, she was noted to have hypophosphatemia with undetectable serum phosphate levels, and she reported mild diarrhea. She was started on oral phosphate supplementation. On a routine visit 2 weeks later, she was found to have an acute increase in serum creatinine level and kidney biopsy was performed. We discuss the causes, management, and complications of hypophosphatemia in kidney transplant.</description><subject>Acetates - therapeutic use</subject><subject>Acute kidney injury</subject><subject>Administration, Oral</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Calcium Compounds - therapeutic use</subject><subject>Creatinine - blood</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Humans</subject><subject>hyperparathyroidism</subject><subject>hypophosphatemia</subject><subject>Hypophosphatemia - drug therapy</subject><subject>Hypophosphatemia - etiology</subject><subject>Kidney - pathology</subject><subject>Kidney Failure, Chronic - surgery</subject><subject>kidney transplant</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Kidneys</subject><subject>Medical sciences</subject><subject>Nephrology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)</subject><subject>phosphate</subject><subject>Phosphates - administration & dosage</subject><subject>Phosphates - adverse effects</subject><subject>Phosphates - therapeutic use</subject><subject>Renal Insufficiency - chemically induced</subject><subject>Renal Insufficiency - diagnosis</subject><subject>Renal Insufficiency - drug therapy</subject><subject>Treatment Outcome</subject><subject>Urinary system involvement in other diseases. 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Urinary tract diseases</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)</topic><topic>phosphate</topic><topic>Phosphates - administration & dosage</topic><topic>Phosphates - adverse effects</topic><topic>Phosphates - therapeutic use</topic><topic>Renal Insufficiency - chemically induced</topic><topic>Renal Insufficiency - diagnosis</topic><topic>Renal Insufficiency - drug therapy</topic><topic>Treatment Outcome</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riella, Leonardo V., MD</creatorcontrib><creatorcontrib>Rennke, Helmut G., MD</creatorcontrib><creatorcontrib>Grafals, Monica, MD</creatorcontrib><creatorcontrib>Chandraker, Anil, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riella, Leonardo V., MD</au><au>Rennke, Helmut G., MD</au><au>Grafals, Monica, MD</au><au>Chandraker, Anil, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypophosphatemia in Kidney Transplant Recipients: Report of Acute Phosphate Nephropathy as a Complication of Therapy</atitle><jtitle>American journal of kidney diseases</jtitle><addtitle>Am J Kidney Dis</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>57</volume><issue>4</issue><spage>641</spage><epage>645</epage><pages>641-645</pages><issn>0272-6386</issn><eissn>1523-6838</eissn><abstract>Hypophosphatemia is a common complication after kidney transplant, affecting >90% of patients. However, no specific recommendations for phosphate repletion exist for transplant recipients. We report a case of a 70-year-old highly sensitized woman with end-stage renal disease caused by diabetic nephropathy who underwent deceased donor kidney transplant. Four weeks later, she was noted to have hypophosphatemia with undetectable serum phosphate levels, and she reported mild diarrhea. She was started on oral phosphate supplementation. On a routine visit 2 weeks later, she was found to have an acute increase in serum creatinine level and kidney biopsy was performed. We discuss the causes, management, and complications of hypophosphatemia in kidney transplant.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21333424</pmid><doi>10.1053/j.ajkd.2010.11.024</doi><tpages>5</tpages></addata></record> |
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| ispartof | American journal of kidney diseases, 2011-04, Vol.57 (4), p.641-645 |
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| subjects | Acetates - therapeutic use Acute kidney injury Administration, Oral Aged Biological and medical sciences Biopsy Calcium Compounds - therapeutic use Creatinine - blood Endocrinopathies Female Humans hyperparathyroidism hypophosphatemia Hypophosphatemia - drug therapy Hypophosphatemia - etiology Kidney - pathology Kidney Failure, Chronic - surgery kidney transplant Kidney Transplantation - adverse effects Kidneys Medical sciences Nephrology Nephrology. Urinary tract diseases Non tumoral diseases. Target tissue resistance. Benign neoplasms Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) phosphate Phosphates - administration & dosage Phosphates - adverse effects Phosphates - therapeutic use Renal Insufficiency - chemically induced Renal Insufficiency - diagnosis Renal Insufficiency - drug therapy Treatment Outcome Urinary system involvement in other diseases. Miscellaneous |
| title | Hypophosphatemia in Kidney Transplant Recipients: Report of Acute Phosphate Nephropathy as a Complication of Therapy |
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