Matrix metalloproteinase‐9 cooperates with transcription factor Snail to induce epithelial–mesenchymal transition

One of the most fundamental biological processes in tumor metastasis is the process of epithelial–mesenchymal transition (EMT). During EMT, zinc‐finger‐family of transcription factors such as Snail, Slug and Twist, and matrix metalloproteinases (MMPs) are upregulated, and this correlates with increa...

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Veröffentlicht in:	Cancer science 2011-04, Vol.102 (4), p.815-827
Hauptverfasser:	Lin, Chun‐Yu, Tsai, Pei‐Hsun, Kandaswami, Chithan C., Lee, Ping‐Ping, Huang, Chang‐Jen, Hwang, Jiuan‐Jiuan, Lee, Ming‐Ting
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Western Cadherins - genetics Cadherins - metabolism Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Cell Movement Epithelial-Mesenchymal Transition - physiology Fluorescent Antibody Technique Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors Medical sciences Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics Snail Family Transcription Factors Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism Tumor Cells, Cultured Tumors Vimentin - genetics Vimentin - metabolism Wound Healing
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