Changes in murine hair with dietary selenium excess or deficiency
: It is known that an excess or deficiency of selenium (Se) causes abnormalities in hair. We evaluated changes in the hair follicles associated with Se imbalance in a C57BL/6 mouse model to better understand the role of Se in hair growth. Fifteen C57BL/6 mice were assigned to diets providing excess...
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| Veröffentlicht in: | Experimental dermatology 2011-04, Vol.20 (4), p.367-369 |
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| creator | Hwang, Seon Wook Lee, Hyun Jae Suh, Kee Suck Kim, Sang Tae Park, Sung Wook Hur, Dae Young Lee, Deborah Seo, Jong Keun Sung, Ho Suk |
| description | : It is known that an excess or deficiency of selenium (Se) causes abnormalities in hair. We evaluated changes in the hair follicles associated with Se imbalance in a C57BL/6 mouse model to better understand the role of Se in hair growth. Fifteen C57BL/6 mice were assigned to diets providing excessive, adequate, or deficient amounts of Se. Alopecia with poliosis was observed in the groups receiving either excessive or deficient selenium. Skin biopsy from alopecia patches showed increased telogen hair follicles with epidermal atrophy. There was a significant decrease of anti‐apoptotic Bcl‐2 and an increase of pro‐apoptotic Bax in the excessive‐Se group compared with the adequate group. We suggest that alopecia with poliosis is caused by changes in the hair follicle cycle due to the imbalance of Se and partially influenced by the decrease of the ratio of Bcl‐2/Bax, which is associated with induction of apoptosis of keratinocytes. |
| doi_str_mv | 10.1111/j.1600-0625.2010.01207.x |
| format | Article |
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We evaluated changes in the hair follicles associated with Se imbalance in a C57BL/6 mouse model to better understand the role of Se in hair growth. Fifteen C57BL/6 mice were assigned to diets providing excessive, adequate, or deficient amounts of Se. Alopecia with poliosis was observed in the groups receiving either excessive or deficient selenium. Skin biopsy from alopecia patches showed increased telogen hair follicles with epidermal atrophy. There was a significant decrease of anti‐apoptotic Bcl‐2 and an increase of pro‐apoptotic Bax in the excessive‐Se group compared with the adequate group. We suggest that alopecia with poliosis is caused by changes in the hair follicle cycle due to the imbalance of Se and partially influenced by the decrease of the ratio of Bcl‐2/Bax, which is associated with induction of apoptosis of keratinocytes.</description><identifier>ISSN: 0906-6705</identifier><identifier>EISSN: 1600-0625</identifier><identifier>DOI: 10.1111/j.1600-0625.2010.01207.x</identifier><identifier>PMID: 21366699</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>alopecia ; Alopecia - metabolism ; Alopecia - pathology ; Animals ; Apoptosis ; bcl-2-Associated X Protein - genetics ; bcl-2-Associated X Protein - metabolism ; Biological and medical sciences ; Dermatology ; Diseases of the digestive system ; Female ; Genes, bcl-2 ; Hair and nails disorders ; Hair Follicle - metabolism ; Hair Follicle - pathology ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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We evaluated changes in the hair follicles associated with Se imbalance in a C57BL/6 mouse model to better understand the role of Se in hair growth. Fifteen C57BL/6 mice were assigned to diets providing excessive, adequate, or deficient amounts of Se. Alopecia with poliosis was observed in the groups receiving either excessive or deficient selenium. Skin biopsy from alopecia patches showed increased telogen hair follicles with epidermal atrophy. There was a significant decrease of anti‐apoptotic Bcl‐2 and an increase of pro‐apoptotic Bax in the excessive‐Se group compared with the adequate group. We suggest that alopecia with poliosis is caused by changes in the hair follicle cycle due to the imbalance of Se and partially influenced by the decrease of the ratio of Bcl‐2/Bax, which is associated with induction of apoptosis of keratinocytes.</description><subject>alopecia</subject><subject>Alopecia - metabolism</subject><subject>Alopecia - pathology</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>bcl-2-Associated X Protein - genetics</subject><subject>bcl-2-Associated X Protein - metabolism</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Diseases of the digestive system</subject><subject>Female</subject><subject>Genes, bcl-2</subject><subject>Hair and nails disorders</subject><subject>Hair Follicle - metabolism</subject><subject>Hair Follicle - pathology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>selenium</subject><subject>Selenium - deficiency</subject><subject>Selenium - metabolism</subject><issn>0906-6705</issn><issn>1600-0625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkctOwzAQRS0EgvL4BeQNYpUydvxoFiygvCmwAcHOcpwJdUlSiBvR_j0JLcWbsWbOtTX3EkIZ9Fl7TiZ9pgAiUFz2ObRdYBx0f75BeuvBJulBAipSGuQO2Q1hAsB0rOU22eEsVkolSY-cDce2esdAfUXLpvYV0rH1Nf32szHNPM5svaABC6x8U1KcOwyBTmuaYe6dx8ot9slWbouAB6u6R16uLp-HN9Ho6fp2eDaKnIi1jnj7O9g845mTXKYKtFNaikzoJAWb5ix1A24TxXSWOA1O2RysEFmeyFwguniPHC_f_aynXw2GmSl9cFgUtsJpE8xA6gETLJYtebgim7TEzHzWvmzXMH9bt8DRCrDB2SKvbeV8-OcE6DhhvOVOl9y3L3CxnjMwXQpmYjqzTWe26VIwvymYubl8u-hurT5a6n2Y4Xytt_WHUV0S5vXx2jxciMe789HA3Mc_SpqIuQ</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Hwang, Seon Wook</creator><creator>Lee, Hyun Jae</creator><creator>Suh, Kee Suck</creator><creator>Kim, Sang Tae</creator><creator>Park, Sung Wook</creator><creator>Hur, Dae Young</creator><creator>Lee, Deborah</creator><creator>Seo, Jong Keun</creator><creator>Sung, Ho Suk</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Changes in murine hair with dietary selenium excess or deficiency</title><author>Hwang, Seon Wook ; Lee, Hyun Jae ; Suh, Kee Suck ; Kim, Sang Tae ; Park, Sung Wook ; Hur, Dae Young ; Lee, Deborah ; Seo, Jong Keun ; Sung, Ho Suk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4377-20010afd2dc525b607c6754d479b0abf1bc82a9617d9c70c6af0a44df95f4eec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>alopecia</topic><topic>Alopecia - metabolism</topic><topic>Alopecia - pathology</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>bcl-2-Associated X Protein - genetics</topic><topic>bcl-2-Associated X Protein - metabolism</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Diseases of the digestive system</topic><topic>Female</topic><topic>Genes, bcl-2</topic><topic>Hair and nails disorders</topic><topic>Hair Follicle - metabolism</topic><topic>Hair Follicle - pathology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Radiotherapy. 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We evaluated changes in the hair follicles associated with Se imbalance in a C57BL/6 mouse model to better understand the role of Se in hair growth. Fifteen C57BL/6 mice were assigned to diets providing excessive, adequate, or deficient amounts of Se. Alopecia with poliosis was observed in the groups receiving either excessive or deficient selenium. Skin biopsy from alopecia patches showed increased telogen hair follicles with epidermal atrophy. There was a significant decrease of anti‐apoptotic Bcl‐2 and an increase of pro‐apoptotic Bax in the excessive‐Se group compared with the adequate group. 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| subjects | alopecia Alopecia - metabolism Alopecia - pathology Animals Apoptosis bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biological and medical sciences Dermatology Diseases of the digestive system Female Genes, bcl-2 Hair and nails disorders Hair Follicle - metabolism Hair Follicle - pathology Medical sciences Mice Mice, Inbred C57BL Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) selenium Selenium - deficiency Selenium - metabolism |
| title | Changes in murine hair with dietary selenium excess or deficiency |
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