The 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity
: There is increasing awareness that psoriasis is more than ‘skin deep’. Several recent reviews focussed on biomarkers indicating the systemic dimension of psoriasis and the aspect of comorbidity psoriasis shares with other chronic inflammatory diseases, such as Crohn’s disease and rheumatoid arthr...
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| Veröffentlicht in: | Experimental dermatology 2011-04, Vol.20 (4), p.303-307 |
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| container_end_page | 307 |
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| container_title | Experimental dermatology |
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| creator | Boehncke, Wolf-Henning Boehncke, Sandra Tobin, Anne-Marie Kirby, Brian |
| description | : There is increasing awareness that psoriasis is more than ‘skin deep’. Several recent reviews focussed on biomarkers indicating the systemic dimension of psoriasis and the aspect of comorbidity psoriasis shares with other chronic inflammatory diseases, such as Crohn’s disease and rheumatoid arthritis. Of emerging significance is the relationship to cardiovascular disease, as this contributes substantially to the patients’ increased mortality. In this viewpoint, we examine currently available evidence favouring the concept of a causal link between psoriasis and cardiovascular disease: systemic inflammation may cause insulin resistance, which in turn triggers endothelial cell dysfunction, leading to atherosclerosis and finally myocardial infarction or stroke. While this ‘psoriatic march’ is not yet formally proven, it raises clinically and academically relevant questions, and gains support by recent observations of numerous investigators. |
| doi_str_mv | 10.1111/j.1600-0625.2011.01261.x |
| format | Article |
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Several recent reviews focussed on biomarkers indicating the systemic dimension of psoriasis and the aspect of comorbidity psoriasis shares with other chronic inflammatory diseases, such as Crohn’s disease and rheumatoid arthritis. Of emerging significance is the relationship to cardiovascular disease, as this contributes substantially to the patients’ increased mortality. In this viewpoint, we examine currently available evidence favouring the concept of a causal link between psoriasis and cardiovascular disease: systemic inflammation may cause insulin resistance, which in turn triggers endothelial cell dysfunction, leading to atherosclerosis and finally myocardial infarction or stroke. 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Vascular system ; Cardiovascular Diseases - etiology ; Chronic Disease ; Cytokines - physiology ; Dermatology ; Disease Progression ; endothelial cell dysfunction ; Endothelial Cells - pathology ; Endothelial Cells - physiology ; Humans ; Inflammation - complications ; insulin resistance ; Insulin Resistance - physiology ; Medical sciences ; psoriasis ; Psoriasis - complications ; Psoriasis. Parapsoriasis. 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Several recent reviews focussed on biomarkers indicating the systemic dimension of psoriasis and the aspect of comorbidity psoriasis shares with other chronic inflammatory diseases, such as Crohn’s disease and rheumatoid arthritis. Of emerging significance is the relationship to cardiovascular disease, as this contributes substantially to the patients’ increased mortality. In this viewpoint, we examine currently available evidence favouring the concept of a causal link between psoriasis and cardiovascular disease: systemic inflammation may cause insulin resistance, which in turn triggers endothelial cell dysfunction, leading to atherosclerosis and finally myocardial infarction or stroke. While this ‘psoriatic march’ is not yet formally proven, it raises clinically and academically relevant questions, and gains support by recent observations of numerous investigators.</description><subject>adipokine</subject><subject>atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Chronic Disease</subject><subject>Cytokines - physiology</subject><subject>Dermatology</subject><subject>Disease Progression</subject><subject>endothelial cell dysfunction</subject><subject>Endothelial Cells - pathology</subject><subject>Endothelial Cells - physiology</subject><subject>Humans</subject><subject>Inflammation - complications</subject><subject>insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Medical sciences</subject><subject>psoriasis</subject><subject>Psoriasis - complications</subject><subject>Psoriasis. Parapsoriasis. 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Vascular system</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Chronic Disease</topic><topic>Cytokines - physiology</topic><topic>Dermatology</topic><topic>Disease Progression</topic><topic>endothelial cell dysfunction</topic><topic>Endothelial Cells - pathology</topic><topic>Endothelial Cells - physiology</topic><topic>Humans</topic><topic>Inflammation - complications</topic><topic>insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Medical sciences</topic><topic>psoriasis</topic><topic>Psoriasis - complications</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boehncke, Wolf-Henning</creatorcontrib><creatorcontrib>Boehncke, Sandra</creatorcontrib><creatorcontrib>Tobin, Anne-Marie</creatorcontrib><creatorcontrib>Kirby, Brian</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boehncke, Wolf-Henning</au><au>Boehncke, Sandra</au><au>Tobin, Anne-Marie</au><au>Kirby, Brian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity</atitle><jtitle>Experimental dermatology</jtitle><addtitle>Exp Dermatol</addtitle><date>2011-04</date><risdate>2011</risdate><volume>20</volume><issue>4</issue><spage>303</spage><epage>307</epage><pages>303-307</pages><issn>0906-6705</issn><eissn>1600-0625</eissn><abstract>: There is increasing awareness that psoriasis is more than ‘skin deep’. 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| fulltext | fulltext |
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| ispartof | Experimental dermatology, 2011-04, Vol.20 (4), p.303-307 |
| issn | 0906-6705 1600-0625 |
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| subjects | adipokine atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - etiology Chronic Disease Cytokines - physiology Dermatology Disease Progression endothelial cell dysfunction Endothelial Cells - pathology Endothelial Cells - physiology Humans Inflammation - complications insulin resistance Insulin Resistance - physiology Medical sciences psoriasis Psoriasis - complications Psoriasis. Parapsoriasis. Lichen |
| title | The 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity |
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