Management of Phyllodes Breast Tumors
: Phyllodes tumors are a rare distinctive fibroepithelial tumors of the breast and their management continues to be questioned. The aim of our study was to examine the treatment and outcome of 165 patients with phyllodes tumors and to review the options for surgical management. This is a retrospect...
Gespeichert in:
| Veröffentlicht in: | The breast journal 2011-03, Vol.17 (2), p.129-137 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 137 |
|---|---|
| container_issue | 2 |
| container_start_page | 129 |
| container_title | The breast journal |
| container_volume | 17 |
| creator | Guillot, Eugenie Couturaud, Benoit Reyal, Fabien Curnier, Alain Ravinet, Julie Laé, Marick Bollet, Marc Pierga, Jean-yves Salmon, Remy Fitoussi, Alfred |
| description | : Phyllodes tumors are a rare distinctive fibroepithelial tumors of the breast and their management continues to be questioned. The aim of our study was to examine the treatment and outcome of 165 patients with phyllodes tumors and to review the options for surgical management. This is a retrospective study of 165 patients who presented to the Institut Curie between January 1994 and November 2008 for benign, borderline or malignant phyllodes tumors. The median follow‐up was 12.65 months [range 0–149.8]. The median age at diagnosis was 44 years [range 17–79]. One hundred and sixty patients (97%) had breast‐conserving treatment, of whom 3 patients (1.8%) had oncoplastic breast surgery. Younger women had a significantly higher chance of having a benign phyllodes tumor (p = 0.0001) or a tumor of small size (p |
| doi_str_mv | 10.1111/j.1524-4741.2010.01045.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_857813850</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>857813850</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4065-33ad3e69b720ad33a2796e483edc4673e12df8b89beb4f329d8fd0fb1b9109943</originalsourceid><addsrcrecordid>eNqNkE9Pg0AQxTdGY2v1KxguxhO4f2E5eNCq1aZqYzD1tllgUCqUykJsv72LrT27yWRfZt6bSX4IOQR7xL6LuUcE5S4POPEotl1bXHirPdTfDfatxoFwCaVvPXRkzBxjTEPMD1GPEiqIrT46e9QL_Q4lLBqnypzpx7ooqhSMc12DNo0TtWVVm2N0kOnCwMn2H6DXu9toeO9OnkcPw6uJm3DsC5cxnTLwwzig2CqmaRD6wCWDNOF-wIDQNJOxDGOIecZomMosxVlM4pDgMORsgM43e5d19dWCaVSZmwSKQi-gao2SIpCESYGtU26cSV0ZU0OmlnVe6nqtCFYdIzVXHQrVoVAdI_XLSK1s9HR7pI1LSHfBPyjWcLkxfOcFrP-9WEXX407ZvLvJ56aB1S6v609lIQRCzZ5GajYdBi_8Zqwi9gObBYJp</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>857813850</pqid></control><display><type>article</type><title>Management of Phyllodes Breast Tumors</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Guillot, Eugenie ; Couturaud, Benoit ; Reyal, Fabien ; Curnier, Alain ; Ravinet, Julie ; Laé, Marick ; Bollet, Marc ; Pierga, Jean-yves ; Salmon, Remy ; Fitoussi, Alfred</creator><creatorcontrib>Guillot, Eugenie ; Couturaud, Benoit ; Reyal, Fabien ; Curnier, Alain ; Ravinet, Julie ; Laé, Marick ; Bollet, Marc ; Pierga, Jean-yves ; Salmon, Remy ; Fitoussi, Alfred ; Breast Cancer Study Group of the Institut Curie ; Breast Cancer Study Group of the Institut Curie</creatorcontrib><description>: Phyllodes tumors are a rare distinctive fibroepithelial tumors of the breast and their management continues to be questioned. The aim of our study was to examine the treatment and outcome of 165 patients with phyllodes tumors and to review the options for surgical management. This is a retrospective study of 165 patients who presented to the Institut Curie between January 1994 and November 2008 for benign, borderline or malignant phyllodes tumors. The median follow‐up was 12.65 months [range 0–149.8]. The median age at diagnosis was 44 years [range 17–79]. One hundred and sixty patients (97%) had breast‐conserving treatment, of whom 3 patients (1.8%) had oncoplastic breast surgery. Younger women had a significantly higher chance of having a benign phyllodes tumor (p = 0.0001) or a tumor of small size (p < 0.0001). Histologic examination showed 114 benign (69%), 37 borderline (22%) and 14 malignant tumors (9%). The median tumor size was 30 mm [range 5–150]. The tumor margins were considered incomplete (<10 mm) in 46 out of 165 cases (28%) with 52% revision surgery. Only the tumor grade was a significant risk factor for incomplete tumor margins (p = 0.005). Fifteen patients developed local recurrence (10%) and two, metastases. In univariate analysis, the histologic grade (p = 0.008), and tumor size (p = 0.02) were significative risk factors for local recurrence with an accentuated risk for “borderline” tumors and tumors of large size.).Similar results were obtained using multivariate analysis (p = 0.07). The mainstay of treatment for phyllodes tumors remains excision with a safe surgical margin, taking advantage breast conserving surgery where amenable. For borderline or malignant phyllodes tumors or in cases of local tumor recurrence, mastectomy, and immediate breast reconstruction may become the preferred option. Genetic analysis will potentially supplement classical histologic examination in order to improve our management of these tumors. The role of adjuvant treatments is unproven and must be considered on a case‐by‐case basis.</description><identifier>ISSN: 1075-122X</identifier><identifier>EISSN: 1524-4741</identifier><identifier>DOI: 10.1111/j.1524-4741.2010.01045.x</identifier><identifier>PMID: 21251125</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; breast cancer ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Chemotherapy, Adjuvant ; Female ; Follow-Up Studies ; Humans ; Incidence ; Mastectomy ; Mastectomy, Segmental ; Middle Aged ; Neoplasm Recurrence, Local - epidemiology ; oncoplastic surgery ; phyllode ; Phyllodes Tumor - pathology ; Phyllodes Tumor - secondary ; Phyllodes Tumor - surgery ; Radiotherapy, Adjuvant ; Reoperation - statistics & numerical data ; Retrospective Studies ; Risk Factors ; Young Adult</subject><ispartof>The breast journal, 2011-03, Vol.17 (2), p.129-137</ispartof><rights>2011 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4065-33ad3e69b720ad33a2796e483edc4673e12df8b89beb4f329d8fd0fb1b9109943</citedby><cites>FETCH-LOGICAL-c4065-33ad3e69b720ad33a2796e483edc4673e12df8b89beb4f329d8fd0fb1b9109943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1524-4741.2010.01045.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1524-4741.2010.01045.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21251125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guillot, Eugenie</creatorcontrib><creatorcontrib>Couturaud, Benoit</creatorcontrib><creatorcontrib>Reyal, Fabien</creatorcontrib><creatorcontrib>Curnier, Alain</creatorcontrib><creatorcontrib>Ravinet, Julie</creatorcontrib><creatorcontrib>Laé, Marick</creatorcontrib><creatorcontrib>Bollet, Marc</creatorcontrib><creatorcontrib>Pierga, Jean-yves</creatorcontrib><creatorcontrib>Salmon, Remy</creatorcontrib><creatorcontrib>Fitoussi, Alfred</creatorcontrib><creatorcontrib>Breast Cancer Study Group of the Institut Curie</creatorcontrib><creatorcontrib>Breast Cancer Study Group of the Institut Curie</creatorcontrib><title>Management of Phyllodes Breast Tumors</title><title>The breast journal</title><addtitle>Breast J</addtitle><description>: Phyllodes tumors are a rare distinctive fibroepithelial tumors of the breast and their management continues to be questioned. The aim of our study was to examine the treatment and outcome of 165 patients with phyllodes tumors and to review the options for surgical management. This is a retrospective study of 165 patients who presented to the Institut Curie between January 1994 and November 2008 for benign, borderline or malignant phyllodes tumors. The median follow‐up was 12.65 months [range 0–149.8]. The median age at diagnosis was 44 years [range 17–79]. One hundred and sixty patients (97%) had breast‐conserving treatment, of whom 3 patients (1.8%) had oncoplastic breast surgery. Younger women had a significantly higher chance of having a benign phyllodes tumor (p = 0.0001) or a tumor of small size (p < 0.0001). Histologic examination showed 114 benign (69%), 37 borderline (22%) and 14 malignant tumors (9%). The median tumor size was 30 mm [range 5–150]. The tumor margins were considered incomplete (<10 mm) in 46 out of 165 cases (28%) with 52% revision surgery. Only the tumor grade was a significant risk factor for incomplete tumor margins (p = 0.005). Fifteen patients developed local recurrence (10%) and two, metastases. In univariate analysis, the histologic grade (p = 0.008), and tumor size (p = 0.02) were significative risk factors for local recurrence with an accentuated risk for “borderline” tumors and tumors of large size.).Similar results were obtained using multivariate analysis (p = 0.07). The mainstay of treatment for phyllodes tumors remains excision with a safe surgical margin, taking advantage breast conserving surgery where amenable. For borderline or malignant phyllodes tumors or in cases of local tumor recurrence, mastectomy, and immediate breast reconstruction may become the preferred option. Genetic analysis will potentially supplement classical histologic examination in order to improve our management of these tumors. The role of adjuvant treatments is unproven and must be considered on a case‐by‐case basis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Chemotherapy, Adjuvant</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Mastectomy</subject><subject>Mastectomy, Segmental</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>oncoplastic surgery</subject><subject>phyllode</subject><subject>Phyllodes Tumor - pathology</subject><subject>Phyllodes Tumor - secondary</subject><subject>Phyllodes Tumor - surgery</subject><subject>Radiotherapy, Adjuvant</subject><subject>Reoperation - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Young Adult</subject><issn>1075-122X</issn><issn>1524-4741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9Pg0AQxTdGY2v1KxguxhO4f2E5eNCq1aZqYzD1tllgUCqUykJsv72LrT27yWRfZt6bSX4IOQR7xL6LuUcE5S4POPEotl1bXHirPdTfDfatxoFwCaVvPXRkzBxjTEPMD1GPEiqIrT46e9QL_Q4lLBqnypzpx7ooqhSMc12DNo0TtWVVm2N0kOnCwMn2H6DXu9toeO9OnkcPw6uJm3DsC5cxnTLwwzig2CqmaRD6wCWDNOF-wIDQNJOxDGOIecZomMosxVlM4pDgMORsgM43e5d19dWCaVSZmwSKQi-gao2SIpCESYGtU26cSV0ZU0OmlnVe6nqtCFYdIzVXHQrVoVAdI_XLSK1s9HR7pI1LSHfBPyjWcLkxfOcFrP-9WEXX407ZvLvJ56aB1S6v609lIQRCzZ5GajYdBi_8Zqwi9gObBYJp</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Guillot, Eugenie</creator><creator>Couturaud, Benoit</creator><creator>Reyal, Fabien</creator><creator>Curnier, Alain</creator><creator>Ravinet, Julie</creator><creator>Laé, Marick</creator><creator>Bollet, Marc</creator><creator>Pierga, Jean-yves</creator><creator>Salmon, Remy</creator><creator>Fitoussi, Alfred</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201103</creationdate><title>Management of Phyllodes Breast Tumors</title><author>Guillot, Eugenie ; Couturaud, Benoit ; Reyal, Fabien ; Curnier, Alain ; Ravinet, Julie ; Laé, Marick ; Bollet, Marc ; Pierga, Jean-yves ; Salmon, Remy ; Fitoussi, Alfred</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4065-33ad3e69b720ad33a2796e483edc4673e12df8b89beb4f329d8fd0fb1b9109943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>breast cancer</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>Chemotherapy, Adjuvant</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Mastectomy</topic><topic>Mastectomy, Segmental</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>oncoplastic surgery</topic><topic>phyllode</topic><topic>Phyllodes Tumor - pathology</topic><topic>Phyllodes Tumor - secondary</topic><topic>Phyllodes Tumor - surgery</topic><topic>Radiotherapy, Adjuvant</topic><topic>Reoperation - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guillot, Eugenie</creatorcontrib><creatorcontrib>Couturaud, Benoit</creatorcontrib><creatorcontrib>Reyal, Fabien</creatorcontrib><creatorcontrib>Curnier, Alain</creatorcontrib><creatorcontrib>Ravinet, Julie</creatorcontrib><creatorcontrib>Laé, Marick</creatorcontrib><creatorcontrib>Bollet, Marc</creatorcontrib><creatorcontrib>Pierga, Jean-yves</creatorcontrib><creatorcontrib>Salmon, Remy</creatorcontrib><creatorcontrib>Fitoussi, Alfred</creatorcontrib><creatorcontrib>Breast Cancer Study Group of the Institut Curie</creatorcontrib><creatorcontrib>Breast Cancer Study Group of the Institut Curie</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The breast journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guillot, Eugenie</au><au>Couturaud, Benoit</au><au>Reyal, Fabien</au><au>Curnier, Alain</au><au>Ravinet, Julie</au><au>Laé, Marick</au><au>Bollet, Marc</au><au>Pierga, Jean-yves</au><au>Salmon, Remy</au><au>Fitoussi, Alfred</au><aucorp>Breast Cancer Study Group of the Institut Curie</aucorp><aucorp>Breast Cancer Study Group of the Institut Curie</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of Phyllodes Breast Tumors</atitle><jtitle>The breast journal</jtitle><addtitle>Breast J</addtitle><date>2011-03</date><risdate>2011</risdate><volume>17</volume><issue>2</issue><spage>129</spage><epage>137</epage><pages>129-137</pages><issn>1075-122X</issn><eissn>1524-4741</eissn><abstract>: Phyllodes tumors are a rare distinctive fibroepithelial tumors of the breast and their management continues to be questioned. The aim of our study was to examine the treatment and outcome of 165 patients with phyllodes tumors and to review the options for surgical management. This is a retrospective study of 165 patients who presented to the Institut Curie between January 1994 and November 2008 for benign, borderline or malignant phyllodes tumors. The median follow‐up was 12.65 months [range 0–149.8]. The median age at diagnosis was 44 years [range 17–79]. One hundred and sixty patients (97%) had breast‐conserving treatment, of whom 3 patients (1.8%) had oncoplastic breast surgery. Younger women had a significantly higher chance of having a benign phyllodes tumor (p = 0.0001) or a tumor of small size (p < 0.0001). Histologic examination showed 114 benign (69%), 37 borderline (22%) and 14 malignant tumors (9%). The median tumor size was 30 mm [range 5–150]. The tumor margins were considered incomplete (<10 mm) in 46 out of 165 cases (28%) with 52% revision surgery. Only the tumor grade was a significant risk factor for incomplete tumor margins (p = 0.005). Fifteen patients developed local recurrence (10%) and two, metastases. In univariate analysis, the histologic grade (p = 0.008), and tumor size (p = 0.02) were significative risk factors for local recurrence with an accentuated risk for “borderline” tumors and tumors of large size.).Similar results were obtained using multivariate analysis (p = 0.07). The mainstay of treatment for phyllodes tumors remains excision with a safe surgical margin, taking advantage breast conserving surgery where amenable. For borderline or malignant phyllodes tumors or in cases of local tumor recurrence, mastectomy, and immediate breast reconstruction may become the preferred option. Genetic analysis will potentially supplement classical histologic examination in order to improve our management of these tumors. The role of adjuvant treatments is unproven and must be considered on a case‐by‐case basis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21251125</pmid><doi>10.1111/j.1524-4741.2010.01045.x</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1075-122X |
| ispartof | The breast journal, 2011-03, Vol.17 (2), p.129-137 |
| issn | 1075-122X 1524-4741 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_857813850 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adolescent Adult Aged breast cancer Breast Neoplasms - pathology Breast Neoplasms - surgery Chemotherapy, Adjuvant Female Follow-Up Studies Humans Incidence Mastectomy Mastectomy, Segmental Middle Aged Neoplasm Recurrence, Local - epidemiology oncoplastic surgery phyllode Phyllodes Tumor - pathology Phyllodes Tumor - secondary Phyllodes Tumor - surgery Radiotherapy, Adjuvant Reoperation - statistics & numerical data Retrospective Studies Risk Factors Young Adult |
| title | Management of Phyllodes Breast Tumors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T12%3A42%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Management%20of%20Phyllodes%20Breast%20Tumors&rft.jtitle=The%20breast%20journal&rft.au=Guillot,%20Eugenie&rft.aucorp=Breast%20Cancer%20Study%20Group%20of%20the%20Institut%20Curie&rft.date=2011-03&rft.volume=17&rft.issue=2&rft.spage=129&rft.epage=137&rft.pages=129-137&rft.issn=1075-122X&rft.eissn=1524-4741&rft_id=info:doi/10.1111/j.1524-4741.2010.01045.x&rft_dat=%3Cproquest_cross%3E857813850%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=857813850&rft_id=info:pmid/21251125&rfr_iscdi=true |