Nucleoside Transport Inhibitors: Structure−Activity Relationships for Pyrimido[5,4-d]pyrimidine Derivatives That Potentiate Pemetrexed Cytotoxicity in the Presence of α1-Acid Glycoprotein

Membrane transport of nucleosides or nucleobases is mediated by transporters including the equilibrative nucleoside transporters (ENTs), and resistance to antitumor antimetabolite drugs may arise via salvage of exogenous purine or pyrimidine nucleosides or nucleobases by ENT transporters. The therap...

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Veröffentlicht in:	Journal of medicinal chemistry 2011-03, Vol.54 (6), p.1847-1859
Hauptverfasser:	Saravanan, Kappusamy, Barlow, Hannah C, Barton, Marion, Calvert, A. Hilary, Golding, Bernard T, Newell, David R, Northen, Julian S, Curtin, Nicola J, Thomas, Huw D, Griffin, Roger J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Biological Transport - drug effects Cell Line, Tumor Drug Synergism Glutamates - pharmacology Guanine - analogs & derivatives Guanine - pharmacology Humans Nucleosides - metabolism Orosomucoid - metabolism Orosomucoid - pharmacology Pemetrexed Prodrugs - chemical synthesis Prodrugs - pharmacokinetics Prodrugs - pharmacology Protein Binding Pyrimidines - chemical synthesis Pyrimidines - pharmacokinetics Pyrimidines - pharmacology Stereoisomerism Structure-Activity Relationship
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