Toward a practical and waste-free synthesis of thioureas in water

An operationally simple and entirely green protocol for the synthesis of thiourea derivatives by the reaction of carbon disulfide with primary amines in pure water is developed. This reaction is a highly atom-economic process for production of highly pure, hindered thioureas without any catalyst and...

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Veröffentlicht in:	Molecular diversity 2011-02, Vol.15 (1), p.157-161
Hauptverfasser:	Azizi, Najmedin, Khajeh-Amiri, Alireza, Ghafuri, Hossein, Bolourtchian, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	amines Atom economy Biochemistry Biomedical and Life Sciences Carbon carbon disulfide Chemical synthesis Drug Discovery Full-Length Paper Green Chemistry Technology - methods hydrochemistry Life Sciences Organic Chemistry Pharmacy Polymer Sciences thiourea Thiourea - chemical synthesis Waste-free Water Water - chemistry
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Beschreibung
Zusammenfassung:	An operationally simple and entirely green protocol for the synthesis of thiourea derivatives by the reaction of carbon disulfide with primary amines in pure water is developed. This reaction is a highly atom-economic process for production of highly pure, hindered thioureas without any catalyst and tedious work-up.
ISSN:	1381-1991 1573-501X
DOI:	10.1007/s11030-010-9236-7