A Case of Micafungin-Hyposensitive Candida glabrata Due to FKS2 Gene Mutation
Candida glabrata was continuously isolated in cultured urine samples from a subject with thrombotic thrombocytopenic purpura. Yeast-like fungal phagocytosis found in gram staining led to agents being tested for antifungal susceptibility, revealing hyposensitivity to micafungin (MCFG) of MIC ＜2mg/mL....
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| Veröffentlicht in: | Kansenshogaku Zasshi 2011/01/20, Vol.85(1), pp.49-53 |
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| container_title | Kansenshogaku Zasshi |
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| creator | INUI, Sachiko NAKAMURA, Tatsuya TANABE, Kouichi OHNO, Hideaki KOIKE, Chihiro OKUDA, Kazuyuki NAKATA, Chiyo FUJIMOTO, Hiroko OHKURA, Hiroe MIYAZAKI, Yoshitsugu TAKAHASHI, Hakuo |
| description | Candida glabrata was continuously isolated in cultured urine samples from a subject with thrombotic thrombocytopenic purpura. Yeast-like fungal phagocytosis found in gram staining led to agents being tested for antifungal susceptibility, revealing hyposensitivity to micafungin (MCFG) of MIC ＜2mg/mL. MCFG administered for 10 days failed to cure C. glabrata infection. To clarify why hyposensitivity occurred, we analyzed the FKS gene sequence using the PCR, finding a deficit of 3 bases coding phenylalanine at FKS2 gene amino acid 659. MCFG hyposensitivity may thus occur in long-term candin-class anti-fungal agent treatment. Candin-class agents have potent anti-fungal activity with fewer adverse effects and are widely used clinically. Hyposensitivity due to resistant C. glabrata species showed thus be considered in fungal infection treatment. |
| doi_str_mv | 10.11150/kansenshogakuzasshi.85.49 |
| format | Article |
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Yeast-like fungal phagocytosis found in gram staining led to agents being tested for antifungal susceptibility, revealing hyposensitivity to micafungin (MCFG) of MIC ＜2mg/mL. MCFG administered for 10 days failed to cure C. glabrata infection. To clarify why hyposensitivity occurred, we analyzed the FKS gene sequence using the PCR, finding a deficit of 3 bases coding phenylalanine at FKS2 gene amino acid 659. MCFG hyposensitivity may thus occur in long-term candin-class anti-fungal agent treatment. Candin-class agents have potent anti-fungal activity with fewer adverse effects and are widely used clinically. 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| identifier | ISSN: 0387-5911 |
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| language | eng ; jpn |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Antifungal Agents - pharmacology Candida glabrata Candida glabrata - drug effects Candida glabrata - genetics Drug Resistance, Fungal - genetics drug resistant Echinocandins - pharmacology Female FKS2 Fungal Proteins - genetics Humans Lipopeptides - pharmacology Micafungin Mutation |
| title | A Case of Micafungin-Hyposensitive Candida glabrata Due to FKS2 Gene Mutation |
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