Masked trial of topical anesthesia for retinopathy of prematurity eye examinations
Purpose To observe the effect of a topical anesthetic on pain and corneal clarity in premature infants undergoing eye examinations for retinopathy of prematurity (ROP). Methods ROP examinations were performed on premature infants who were randomized to receive either proparacaine 0.5% or an artifici...
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| Veröffentlicht in: | Journal of AAPOS 2011-02, Vol.15 (1), p.45-48 |
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| creator | Cogen, Martin S., MD Parker, Jack S Sleep, Todd E., MD Elsas, Frederick J., MD Metz, Thomas H., MD McGwin, Gerald, PhD |
| description | Purpose To observe the effect of a topical anesthetic on pain and corneal clarity in premature infants undergoing eye examinations for retinopathy of prematurity (ROP). Methods ROP examinations were performed on premature infants who were randomized to receive either proparacaine 0.5% or an artificial tear solution in the right eye. All infants received an artificial tear solution in the left eye. Assessment of discomfort was performed by use of the Premature Infant Pain Profile (PIPP) during examination of the right eye, with a painful event defined as a PIPP score ≥11. The left eye was then examined and a comparison of corneal clarity was made between the 2 eyes. Results A total of 39 examinations were performed on 34 infants: artificial tear solution was administered 17 times and topical proparacaine anesthetic 22 times. The mean PIPP score for those receiving artificial tears was 10.4 compared with 8.8 for the anesthetic group ( p = 0.17). Of the examinations without anesthetic, 65% were painful, compared with 27% with anesthetic ( p = 0.04). No effect on corneal clarity was observed in any examination. Conclusions The use of a topical anesthetic appears to marginally decrease pain and has no adverse effect on subjectively assessed corneal clarity during examination of premature infants for ROP. |
| doi_str_mv | 10.1016/j.jaapos.2010.11.011 |
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Methods ROP examinations were performed on premature infants who were randomized to receive either proparacaine 0.5% or an artificial tear solution in the right eye. All infants received an artificial tear solution in the left eye. Assessment of discomfort was performed by use of the Premature Infant Pain Profile (PIPP) during examination of the right eye, with a painful event defined as a PIPP score ≥11. The left eye was then examined and a comparison of corneal clarity was made between the 2 eyes. Results A total of 39 examinations were performed on 34 infants: artificial tear solution was administered 17 times and topical proparacaine anesthetic 22 times. The mean PIPP score for those receiving artificial tears was 10.4 compared with 8.8 for the anesthetic group ( p = 0.17). Of the examinations without anesthetic, 65% were painful, compared with 27% with anesthetic ( p = 0.04). No effect on corneal clarity was observed in any examination. Conclusions The use of a topical anesthetic appears to marginally decrease pain and has no adverse effect on subjectively assessed corneal clarity during examination of premature infants for ROP.</description><identifier>ISSN: 1091-8531</identifier><identifier>EISSN: 1528-3933</identifier><identifier>DOI: 10.1016/j.jaapos.2010.11.011</identifier><identifier>PMID: 21397805</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Administration, Topical ; Anesthetics, Local - administration & dosage ; Double-Blind Method ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Intensive Care Units, Neonatal ; Ophthalmic Solutions - administration & dosage ; Ophthalmology ; Pain - drug therapy ; Pain Measurement ; Physical Examination ; Propoxycaine - administration & dosage ; Retinopathy of Prematurity - diagnosis</subject><ispartof>Journal of AAPOS, 2011-02, Vol.15 (1), p.45-48</ispartof><rights>American Association for Pediatric Ophthalmology and Strabismus</rights><rights>2011 American Association for Pediatric Ophthalmology and Strabismus</rights><rights>Copyright © 2011 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-baf139777d0d9a099c4af64fad8bbe112de84f381760dafe45fa5b65652f7b9f3</citedby><cites>FETCH-LOGICAL-c416t-baf139777d0d9a099c4af64fad8bbe112de84f381760dafe45fa5b65652f7b9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaapos.2010.11.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21397805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cogen, Martin S., MD</creatorcontrib><creatorcontrib>Parker, Jack S</creatorcontrib><creatorcontrib>Sleep, Todd E., MD</creatorcontrib><creatorcontrib>Elsas, Frederick J., MD</creatorcontrib><creatorcontrib>Metz, Thomas H., MD</creatorcontrib><creatorcontrib>McGwin, Gerald, PhD</creatorcontrib><title>Masked trial of topical anesthesia for retinopathy of prematurity eye examinations</title><title>Journal of AAPOS</title><addtitle>J AAPOS</addtitle><description>Purpose To observe the effect of a topical anesthetic on pain and corneal clarity in premature infants undergoing eye examinations for retinopathy of prematurity (ROP). Methods ROP examinations were performed on premature infants who were randomized to receive either proparacaine 0.5% or an artificial tear solution in the right eye. All infants received an artificial tear solution in the left eye. Assessment of discomfort was performed by use of the Premature Infant Pain Profile (PIPP) during examination of the right eye, with a painful event defined as a PIPP score ≥11. The left eye was then examined and a comparison of corneal clarity was made between the 2 eyes. Results A total of 39 examinations were performed on 34 infants: artificial tear solution was administered 17 times and topical proparacaine anesthetic 22 times. The mean PIPP score for those receiving artificial tears was 10.4 compared with 8.8 for the anesthetic group ( p = 0.17). Of the examinations without anesthetic, 65% were painful, compared with 27% with anesthetic ( p = 0.04). No effect on corneal clarity was observed in any examination. Conclusions The use of a topical anesthetic appears to marginally decrease pain and has no adverse effect on subjectively assessed corneal clarity during examination of premature infants for ROP.</description><subject>Administration, Topical</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Double-Blind Method</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Very Low Birth Weight</subject><subject>Intensive Care Units, Neonatal</subject><subject>Ophthalmic Solutions - administration & dosage</subject><subject>Ophthalmology</subject><subject>Pain - drug therapy</subject><subject>Pain Measurement</subject><subject>Physical Examination</subject><subject>Propoxycaine - administration & dosage</subject><subject>Retinopathy of Prematurity - diagnosis</subject><issn>1091-8531</issn><issn>1528-3933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1TAQhS0EoqXwDxDKjlUunjjOY4OEKl5SEVJb1tbEHqtOkzjYDuL--zq6hQUbVh5ZZ2bOfIex18APwKF5Nx5GxNXHQ8X3LzhwgCfsHGTVlaIX4mmueQ9lJwWcsRcxjpzzpgd4zs4qEH3bcXnOrr9hvCdTpOBwKrwtkl-dziUuFNMdRYeF9aEIlNziV0x3x121BpoxbcGlY0FHKug3zm7B5PwSX7JnFqdIrx7fC_bj08fbyy_l1ffPXy8_XJW6hiaVA9rdRdsabnrkfa9rtE1t0XTDQACVoa62ooO24QYt1dKiHBrZyMq2Q2_FBXt7mrsG_3PLbtXsoqZpytb9FlUnWxBQCZmV9Umpg48xkFVrcDOGowKudphqVCeYaoepAFSGmdvePC7YhpnM36Y_9LLg_UlA-cxfjoKK2tGiybhAOinj3f82_DtAT27Z-d9nqnH0W1gyQgUqVoqrmz3QPU-AnCWvavEAPROdxg</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Cogen, Martin S., MD</creator><creator>Parker, Jack S</creator><creator>Sleep, Todd E., MD</creator><creator>Elsas, Frederick J., MD</creator><creator>Metz, Thomas H., MD</creator><creator>McGwin, Gerald, PhD</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110201</creationdate><title>Masked trial of topical anesthesia for retinopathy of prematurity eye examinations</title><author>Cogen, Martin S., MD ; Parker, Jack S ; Sleep, Todd E., MD ; Elsas, Frederick J., MD ; Metz, Thomas H., MD ; McGwin, Gerald, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-baf139777d0d9a099c4af64fad8bbe112de84f381760dafe45fa5b65652f7b9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Administration, Topical</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Double-Blind Method</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Very Low Birth Weight</topic><topic>Intensive Care Units, Neonatal</topic><topic>Ophthalmic Solutions - administration & dosage</topic><topic>Ophthalmology</topic><topic>Pain - drug therapy</topic><topic>Pain Measurement</topic><topic>Physical Examination</topic><topic>Propoxycaine - administration & dosage</topic><topic>Retinopathy of Prematurity - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cogen, Martin S., MD</creatorcontrib><creatorcontrib>Parker, Jack S</creatorcontrib><creatorcontrib>Sleep, Todd E., MD</creatorcontrib><creatorcontrib>Elsas, Frederick J., MD</creatorcontrib><creatorcontrib>Metz, Thomas H., MD</creatorcontrib><creatorcontrib>McGwin, Gerald, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of AAPOS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cogen, Martin S., MD</au><au>Parker, Jack S</au><au>Sleep, Todd E., MD</au><au>Elsas, Frederick J., MD</au><au>Metz, Thomas H., MD</au><au>McGwin, Gerald, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Masked trial of topical anesthesia for retinopathy of prematurity eye examinations</atitle><jtitle>Journal of AAPOS</jtitle><addtitle>J AAPOS</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>15</volume><issue>1</issue><spage>45</spage><epage>48</epage><pages>45-48</pages><issn>1091-8531</issn><eissn>1528-3933</eissn><abstract>Purpose To observe the effect of a topical anesthetic on pain and corneal clarity in premature infants undergoing eye examinations for retinopathy of prematurity (ROP). Methods ROP examinations were performed on premature infants who were randomized to receive either proparacaine 0.5% or an artificial tear solution in the right eye. All infants received an artificial tear solution in the left eye. Assessment of discomfort was performed by use of the Premature Infant Pain Profile (PIPP) during examination of the right eye, with a painful event defined as a PIPP score ≥11. The left eye was then examined and a comparison of corneal clarity was made between the 2 eyes. Results A total of 39 examinations were performed on 34 infants: artificial tear solution was administered 17 times and topical proparacaine anesthetic 22 times. The mean PIPP score for those receiving artificial tears was 10.4 compared with 8.8 for the anesthetic group ( p = 0.17). Of the examinations without anesthetic, 65% were painful, compared with 27% with anesthetic ( p = 0.04). No effect on corneal clarity was observed in any examination. Conclusions The use of a topical anesthetic appears to marginally decrease pain and has no adverse effect on subjectively assessed corneal clarity during examination of premature infants for ROP.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>21397805</pmid><doi>10.1016/j.jaapos.2010.11.011</doi><tpages>4</tpages></addata></record> |
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| subjects | Administration, Topical Anesthetics, Local - administration & dosage Double-Blind Method Gestational Age Humans Infant, Newborn Infant, Premature Infant, Very Low Birth Weight Intensive Care Units, Neonatal Ophthalmic Solutions - administration & dosage Ophthalmology Pain - drug therapy Pain Measurement Physical Examination Propoxycaine - administration & dosage Retinopathy of Prematurity - diagnosis |
| title | Masked trial of topical anesthesia for retinopathy of prematurity eye examinations |
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