Discovery of benzothiazole-based adenosine A₂B receptor antagonists with improved A₂A selectivity

The highly potent but modestly selective N-(2-amino-4-methoxy-benzothiazol-7-yl)-N-ethyl-acetamide derivative 2 was selected as the starting point for the design of novel selective A₂B antagonists, due to its excellent potency, and good drug-like properties. A series of compounds containing nonaroma...

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