Chimeric porcine reproductive and respiratory syndrome viruses reveal full function of genotype 1 envelope proteins in the backbone of genotype 2

Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) is classified into two genotypes, type 1 and type 2, which share only about 60% genetic identity. Here, we report viable chimeric viruses in which the envelope protein genes from ORF2a to ORF5 of vSHE (type 1) were swapped into the...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2011-03, Vol.412 (1), p.1-8
Hauptverfasser:	Tian, Debin, Zheng, Haihong, Zhang, Rong, Zhuang, Jinshan, Yuan, Shishan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Chimeric Envelope proteins Genes, Viral Genomic Instability Genotype Infectious Disease Porcine reproductive and respiratory syndrome virus Porcine respiratory and reproductive syndrome virus - genetics Porcine respiratory and reproductive syndrome virus - physiology Recombination, Genetic RNA, Viral - genetics Swine Two genotypes Viral Envelope Proteins - genetics Viral Envelope Proteins - metabolism Virus Replication
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