Antihypertensive effects of isoquercitrin and extracts from Tropaeolum majus L.: Evidence for the inhibition of angiotensin converting enzyme

The effects of extract, purified fraction and isoquercitrin, an active flavonol of T. majus were evaluated on MAP in rats. Our results revealed that the isoquercitrin-induced hypotension is an event dependent on the inhibition of angiotensin II generation by ACE. Previous studies have shown that the...

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Veröffentlicht in:	Journal of ethnopharmacology 2011-03, Vol.134 (2), p.363-372
Hauptverfasser:	Gasparotto Junior, Arquimedes, Gasparotto, Francielly Mourão, Lourenço, Emerson Luiz Botelho, Crestani, Sandra, Stefanello, Maria Elida Alves, Salvador, Marcos José, da Silva-Santos, José Eduardo, Marques, Maria Consuelo Andrade, Kassuya, Cândida Aparecida Leite
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE inhibitors angiotensin I Angiotensin I - antagonists & inhibitors angiotensin II Angiotensin-Converting Enzyme Inhibitors - analysis Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals Antihypertensive Agents - analysis Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use antihypertensive effect Biological and medical sciences blood pressure Blood Pressure - drug effects carotid arteries catheters Dose-Response Relationship, Drug Flavonol fluorometry General pharmacology heart rate Hypertension Hypertension - drug therapy Hypertension - metabolism hypotension intravenous injection isoquercitrin kaempferol ketamine Male Medical sciences oral administration peptidyl-dipeptidase A Peptidyl-Dipeptidase A - metabolism Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves polyethylene Quercetin - analogs & derivatives Quercetin - analysis Quercetin - pharmacology Quercetin - therapeutic use Rats Rats, Inbred SHR Rats, Wistar Tropaeolaceae Tropaeolum - chemistry Tropaeolum majus xylazine
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