Effects of perinatal cocaine exposure on open field behavior and the response to corticotropin releasing hormone (CRH) in rat offspring

Abstract Previous reports indicate that prenatal cocaine exposure alters specific behaviors and hypothalamic–pituitary–adrenal axis (HPA) function in the offspring. In most previous studies, cocaine was given via subcutaneous injections. However intravenous administration more closely mimics human c...

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Veröffentlicht in:	Brain research 2011-01, Vol.1370 (25), p.136-144
Hauptverfasser:	Sithisarn, Thitinart, Bada, Henrietta S, Dai, Hongying, Randall, David C, Legan, Sandra J
Format:	Artikel
Sprache:	eng
Schlagworte:	adolescents Animals Animals, Newborn Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences brain cocaine Cocaine-Related Disorders - metabolism Cocaine-Related Disorders - physiopathology Cocaine-Related Disorders - psychology corticosterone corticotropin Corticotropin-Releasing Hormone - metabolism Corticotropin-Releasing Hormone - pharmacology Corticotropin-Releasing Hormone - secretion CRH Drug addictions Female females HPA axis humans intravenous injection long term effects Male males Medical sciences mothers Neurobehavior Neurology Neuropharmacology Open field test Pharmacology. Drug treatments Pregnancy Prenatal cocaine Prenatal Exposure Delayed Effects - metabolism Prenatal Exposure Delayed Effects - physiopathology Prenatal Exposure Delayed Effects - psychology progeny Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley stress response Stress, Psychological - chemically induced Stress, Psychological - metabolism Stress, Psychological - physiopathology Toxicology weanlings
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