Hypothalamic serotonin-1A receptor binding measured by PET predicts the plasma level of dehydroepiandrosterone sulfate in healthy women
Serotonin modulates the activity of the hypothalamic–pituitary–adrenal (HPA) axis particularly via the serotonin-1A receptor (5-HT 1A). Therefore, the rationale of this positron emission tomography (PET) study was to investigate the influence of the 5-HT 1A receptor distribution in the human brain o...
Gespeichert in:
| Veröffentlicht in: | Neuroscience letters 2010-06, Vol.476 (3), p.161-165 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 165 |
|---|---|
| container_issue | 3 |
| container_start_page | 161 |
| container_title | Neuroscience letters |
| container_volume | 476 |
| creator | Moser, Ulrike Wadsak, Wolfgang Spindelegger, Christoph Mitterhauser, Markus Mien, Leonhard-Key Bieglmayer, Christian Kletter, Kurt Kasper, Siegfried Lanzenberger, Rupert |
| description | Serotonin modulates the activity of the hypothalamic–pituitary–adrenal (HPA) axis particularly via the serotonin-1A receptor (5-HT
1A). Therefore, the rationale of this positron emission tomography (PET) study was to investigate the influence of the 5-HT
1A receptor distribution in the human brain on plasma levels of dehydroepiandrosterone sulfate (DHEAS) and cortisol
in vivo. Eighteen healthy female were measured with PET and the selective 5-HT
1A receptor radioligand [carbonyl-
11C]WAY-100635. Nine a priori defined brain regions (hypothalamus, orbitofrontal cortex, amygdala, hippocampus, anterior and posterior cingulate cortices, dorsal raphe nucleus, retrosplenial cortex, and insula) and the cerebellum (reference region) were delineated on coregistered MR images. DHEAS and cortisol plasma levels were collected by blood sampling in the morning of the PET day. Linear regression analysis of DHEAS plasma level as dependent variable and hypothalamic 5-HT
1A receptor binding potential (BP) as independent variable showed a highly significant association (
r
=
.691,
p
=
.002). The hypothalamic 5-HT
1A BP predicted 47.7% of the variability in DHEAS plasma levels. Regressions were borderline significant (
p
<
.01, Bonferroni corrected threshold |
| doi_str_mv | 10.1016/j.neulet.2010.04.020 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_856787833</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S030439401000457X</els_id><sourcerecordid>856787833</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-c28e9821c6fad84735310f5e04a068a190029ce6cf489dacd56feaa144396b393</originalsourceid><addsrcrecordid>eNqFkc1u1DAQgC0EokvhDRDyBXHK4r8k9gWpqvqDVAkO5Wx5nQnrlWMH22mVJ-C1cbUL3OA0o9E3M_Z8CL2lZEsJ7T4etgEWD2XLSC0RsSWMPEMbKnvW9Kpnz9GGcCIargQ5Q69yPhBCWtqKl-iMEa6U5GqDft6ucyx7483kLM6QYonBhYZe4AQW5hIT3rkwuPAdT2DykmDAuxV_vbrHc82dLRmXPeDZmzwZ7OEBPI4jHmC_DinC7EyoMZc6OgDOix9NAewC3oPxZb_ixzhBeI1ejMZneHOK5-jb9dX95W1z9-Xm8-XFXWMF46WxTIKSjNpuNIMUPW85JWMLRBjSSUMVIUxZ6OwopBqMHdpuBGOoEFx1O674OfpwnDun-GOBXPTksgXvTYC4ZC3brpe95Py_ZM9523ImWSXFkbT1nznBqOfkJpNWTYl-cqUP-uhKP7nSROjqqra9Oy1YdhMMf5p-y6nA-xNgsjV-TCZYl_9ydXe9RVu5T0cO6uEeHCSdrYNgq53qsOghun-_5BfuzrZk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733553282</pqid></control><display><type>article</type><title>Hypothalamic serotonin-1A receptor binding measured by PET predicts the plasma level of dehydroepiandrosterone sulfate in healthy women</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Moser, Ulrike ; Wadsak, Wolfgang ; Spindelegger, Christoph ; Mitterhauser, Markus ; Mien, Leonhard-Key ; Bieglmayer, Christian ; Kletter, Kurt ; Kasper, Siegfried ; Lanzenberger, Rupert</creator><creatorcontrib>Moser, Ulrike ; Wadsak, Wolfgang ; Spindelegger, Christoph ; Mitterhauser, Markus ; Mien, Leonhard-Key ; Bieglmayer, Christian ; Kletter, Kurt ; Kasper, Siegfried ; Lanzenberger, Rupert</creatorcontrib><description>Serotonin modulates the activity of the hypothalamic–pituitary–adrenal (HPA) axis particularly via the serotonin-1A receptor (5-HT
1A). Therefore, the rationale of this positron emission tomography (PET) study was to investigate the influence of the 5-HT
1A receptor distribution in the human brain on plasma levels of dehydroepiandrosterone sulfate (DHEAS) and cortisol
in vivo. Eighteen healthy female were measured with PET and the selective 5-HT
1A receptor radioligand [carbonyl-
11C]WAY-100635. Nine a priori defined brain regions (hypothalamus, orbitofrontal cortex, amygdala, hippocampus, anterior and posterior cingulate cortices, dorsal raphe nucleus, retrosplenial cortex, and insula) and the cerebellum (reference region) were delineated on coregistered MR images. DHEAS and cortisol plasma levels were collected by blood sampling in the morning of the PET day. Linear regression analysis of DHEAS plasma level as dependent variable and hypothalamic 5-HT
1A receptor binding potential (BP) as independent variable showed a highly significant association (
r
=
.691,
p
=
.002). The hypothalamic 5-HT
1A BP predicted 47.7% of the variability in DHEAS plasma levels. Regressions were borderline significant (
p
<
.01, Bonferroni corrected threshold <.0056) between 5-HT
1A BP in the anterior cingulate and orbitofrontal cortices and free cortisol levels. No significant associations between DHEAS or cortisol and the 5-HT
1A receptor BP in other investigated brain regions were found. In conclusion, the serotonergic system may influence the DHEAS plasma level by modulating CRH and ACTH release via hypothalamic 5-HT
1A receptors as reported for cortisol before. As disturbances of the HPA axis as well as changes of the 5-HT
1A receptor distribution have been reported in affective disorders, future studies should focus on these interactions.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2010.04.020</identifier><identifier>PMID: 20399839</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>5-HT 1A receptor ; Adult ; Biological and medical sciences ; Carbon Radioisotopes ; Dehydroepiandrosterone Sulfate - blood ; DHEAS ; Female ; Fundamental and applied biological sciences. Psychology ; HPA axis ; Humans ; Hydrocortisone - blood ; Hypothalamus ; Hypothalamus - diagnostic imaging ; Hypothalamus - metabolism ; PET ; Piperazines - metabolism ; Positron-Emission Tomography ; Predictive Value of Tests ; Pyridines - metabolism ; Radiopharmaceuticals - metabolism ; Receptor, Serotonin, 5-HT1A - metabolism ; Vertebrates: nervous system and sense organs ; Young Adult</subject><ispartof>Neuroscience letters, 2010-06, Vol.476 (3), p.161-165</ispartof><rights>2010 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-c28e9821c6fad84735310f5e04a068a190029ce6cf489dacd56feaa144396b393</citedby><cites>FETCH-LOGICAL-c423t-c28e9821c6fad84735310f5e04a068a190029ce6cf489dacd56feaa144396b393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030439401000457X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22829825$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20399839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moser, Ulrike</creatorcontrib><creatorcontrib>Wadsak, Wolfgang</creatorcontrib><creatorcontrib>Spindelegger, Christoph</creatorcontrib><creatorcontrib>Mitterhauser, Markus</creatorcontrib><creatorcontrib>Mien, Leonhard-Key</creatorcontrib><creatorcontrib>Bieglmayer, Christian</creatorcontrib><creatorcontrib>Kletter, Kurt</creatorcontrib><creatorcontrib>Kasper, Siegfried</creatorcontrib><creatorcontrib>Lanzenberger, Rupert</creatorcontrib><title>Hypothalamic serotonin-1A receptor binding measured by PET predicts the plasma level of dehydroepiandrosterone sulfate in healthy women</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Serotonin modulates the activity of the hypothalamic–pituitary–adrenal (HPA) axis particularly via the serotonin-1A receptor (5-HT
1A). Therefore, the rationale of this positron emission tomography (PET) study was to investigate the influence of the 5-HT
1A receptor distribution in the human brain on plasma levels of dehydroepiandrosterone sulfate (DHEAS) and cortisol
in vivo. Eighteen healthy female were measured with PET and the selective 5-HT
1A receptor radioligand [carbonyl-
11C]WAY-100635. Nine a priori defined brain regions (hypothalamus, orbitofrontal cortex, amygdala, hippocampus, anterior and posterior cingulate cortices, dorsal raphe nucleus, retrosplenial cortex, and insula) and the cerebellum (reference region) were delineated on coregistered MR images. DHEAS and cortisol plasma levels were collected by blood sampling in the morning of the PET day. Linear regression analysis of DHEAS plasma level as dependent variable and hypothalamic 5-HT
1A receptor binding potential (BP) as independent variable showed a highly significant association (
r
=
.691,
p
=
.002). The hypothalamic 5-HT
1A BP predicted 47.7% of the variability in DHEAS plasma levels. Regressions were borderline significant (
p
<
.01, Bonferroni corrected threshold <.0056) between 5-HT
1A BP in the anterior cingulate and orbitofrontal cortices and free cortisol levels. No significant associations between DHEAS or cortisol and the 5-HT
1A receptor BP in other investigated brain regions were found. In conclusion, the serotonergic system may influence the DHEAS plasma level by modulating CRH and ACTH release via hypothalamic 5-HT
1A receptors as reported for cortisol before. As disturbances of the HPA axis as well as changes of the 5-HT
1A receptor distribution have been reported in affective disorders, future studies should focus on these interactions.</description><subject>5-HT 1A receptor</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carbon Radioisotopes</subject><subject>Dehydroepiandrosterone Sulfate - blood</subject><subject>DHEAS</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HPA axis</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Hypothalamus</subject><subject>Hypothalamus - diagnostic imaging</subject><subject>Hypothalamus - metabolism</subject><subject>PET</subject><subject>Piperazines - metabolism</subject><subject>Positron-Emission Tomography</subject><subject>Predictive Value of Tests</subject><subject>Pyridines - metabolism</subject><subject>Radiopharmaceuticals - metabolism</subject><subject>Receptor, Serotonin, 5-HT1A - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Young Adult</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAQgC0EokvhDRDyBXHK4r8k9gWpqvqDVAkO5Wx5nQnrlWMH22mVJ-C1cbUL3OA0o9E3M_Z8CL2lZEsJ7T4etgEWD2XLSC0RsSWMPEMbKnvW9Kpnz9GGcCIargQ5Q69yPhBCWtqKl-iMEa6U5GqDft6ucyx7483kLM6QYonBhYZe4AQW5hIT3rkwuPAdT2DykmDAuxV_vbrHc82dLRmXPeDZmzwZ7OEBPI4jHmC_DinC7EyoMZc6OgDOix9NAewC3oPxZb_ixzhBeI1ejMZneHOK5-jb9dX95W1z9-Xm8-XFXWMF46WxTIKSjNpuNIMUPW85JWMLRBjSSUMVIUxZ6OwopBqMHdpuBGOoEFx1O674OfpwnDun-GOBXPTksgXvTYC4ZC3brpe95Py_ZM9523ImWSXFkbT1nznBqOfkJpNWTYl-cqUP-uhKP7nSROjqqra9Oy1YdhMMf5p-y6nA-xNgsjV-TCZYl_9ydXe9RVu5T0cO6uEeHCSdrYNgq53qsOghun-_5BfuzrZk</recordid><startdate>20100607</startdate><enddate>20100607</enddate><creator>Moser, Ulrike</creator><creator>Wadsak, Wolfgang</creator><creator>Spindelegger, Christoph</creator><creator>Mitterhauser, Markus</creator><creator>Mien, Leonhard-Key</creator><creator>Bieglmayer, Christian</creator><creator>Kletter, Kurt</creator><creator>Kasper, Siegfried</creator><creator>Lanzenberger, Rupert</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20100607</creationdate><title>Hypothalamic serotonin-1A receptor binding measured by PET predicts the plasma level of dehydroepiandrosterone sulfate in healthy women</title><author>Moser, Ulrike ; Wadsak, Wolfgang ; Spindelegger, Christoph ; Mitterhauser, Markus ; Mien, Leonhard-Key ; Bieglmayer, Christian ; Kletter, Kurt ; Kasper, Siegfried ; Lanzenberger, Rupert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-c28e9821c6fad84735310f5e04a068a190029ce6cf489dacd56feaa144396b393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>5-HT 1A receptor</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Carbon Radioisotopes</topic><topic>Dehydroepiandrosterone Sulfate - blood</topic><topic>DHEAS</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HPA axis</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Hypothalamus</topic><topic>Hypothalamus - diagnostic imaging</topic><topic>Hypothalamus - metabolism</topic><topic>PET</topic><topic>Piperazines - metabolism</topic><topic>Positron-Emission Tomography</topic><topic>Predictive Value of Tests</topic><topic>Pyridines - metabolism</topic><topic>Radiopharmaceuticals - metabolism</topic><topic>Receptor, Serotonin, 5-HT1A - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moser, Ulrike</creatorcontrib><creatorcontrib>Wadsak, Wolfgang</creatorcontrib><creatorcontrib>Spindelegger, Christoph</creatorcontrib><creatorcontrib>Mitterhauser, Markus</creatorcontrib><creatorcontrib>Mien, Leonhard-Key</creatorcontrib><creatorcontrib>Bieglmayer, Christian</creatorcontrib><creatorcontrib>Kletter, Kurt</creatorcontrib><creatorcontrib>Kasper, Siegfried</creatorcontrib><creatorcontrib>Lanzenberger, Rupert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moser, Ulrike</au><au>Wadsak, Wolfgang</au><au>Spindelegger, Christoph</au><au>Mitterhauser, Markus</au><au>Mien, Leonhard-Key</au><au>Bieglmayer, Christian</au><au>Kletter, Kurt</au><au>Kasper, Siegfried</au><au>Lanzenberger, Rupert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypothalamic serotonin-1A receptor binding measured by PET predicts the plasma level of dehydroepiandrosterone sulfate in healthy women</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2010-06-07</date><risdate>2010</risdate><volume>476</volume><issue>3</issue><spage>161</spage><epage>165</epage><pages>161-165</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Serotonin modulates the activity of the hypothalamic–pituitary–adrenal (HPA) axis particularly via the serotonin-1A receptor (5-HT
1A). Therefore, the rationale of this positron emission tomography (PET) study was to investigate the influence of the 5-HT
1A receptor distribution in the human brain on plasma levels of dehydroepiandrosterone sulfate (DHEAS) and cortisol
in vivo. Eighteen healthy female were measured with PET and the selective 5-HT
1A receptor radioligand [carbonyl-
11C]WAY-100635. Nine a priori defined brain regions (hypothalamus, orbitofrontal cortex, amygdala, hippocampus, anterior and posterior cingulate cortices, dorsal raphe nucleus, retrosplenial cortex, and insula) and the cerebellum (reference region) were delineated on coregistered MR images. DHEAS and cortisol plasma levels were collected by blood sampling in the morning of the PET day. Linear regression analysis of DHEAS plasma level as dependent variable and hypothalamic 5-HT
1A receptor binding potential (BP) as independent variable showed a highly significant association (
r
=
.691,
p
=
.002). The hypothalamic 5-HT
1A BP predicted 47.7% of the variability in DHEAS plasma levels. Regressions were borderline significant (
p
<
.01, Bonferroni corrected threshold <.0056) between 5-HT
1A BP in the anterior cingulate and orbitofrontal cortices and free cortisol levels. No significant associations between DHEAS or cortisol and the 5-HT
1A receptor BP in other investigated brain regions were found. In conclusion, the serotonergic system may influence the DHEAS plasma level by modulating CRH and ACTH release via hypothalamic 5-HT
1A receptors as reported for cortisol before. As disturbances of the HPA axis as well as changes of the 5-HT
1A receptor distribution have been reported in affective disorders, future studies should focus on these interactions.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>20399839</pmid><doi>10.1016/j.neulet.2010.04.020</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 2010-06, Vol.476 (3), p.161-165 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_856787833 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 5-HT 1A receptor Adult Biological and medical sciences Carbon Radioisotopes Dehydroepiandrosterone Sulfate - blood DHEAS Female Fundamental and applied biological sciences. Psychology HPA axis Humans Hydrocortisone - blood Hypothalamus Hypothalamus - diagnostic imaging Hypothalamus - metabolism PET Piperazines - metabolism Positron-Emission Tomography Predictive Value of Tests Pyridines - metabolism Radiopharmaceuticals - metabolism Receptor, Serotonin, 5-HT1A - metabolism Vertebrates: nervous system and sense organs Young Adult |
| title | Hypothalamic serotonin-1A receptor binding measured by PET predicts the plasma level of dehydroepiandrosterone sulfate in healthy women |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T01%3A39%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hypothalamic%20serotonin-1A%20receptor%20binding%20measured%20by%20PET%20predicts%20the%20plasma%20level%20of%20dehydroepiandrosterone%20sulfate%20in%20healthy%20women&rft.jtitle=Neuroscience%20letters&rft.au=Moser,%20Ulrike&rft.date=2010-06-07&rft.volume=476&rft.issue=3&rft.spage=161&rft.epage=165&rft.pages=161-165&rft.issn=0304-3940&rft.eissn=1872-7972&rft.coden=NELED5&rft_id=info:doi/10.1016/j.neulet.2010.04.020&rft_dat=%3Cproquest_cross%3E856787833%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733553282&rft_id=info:pmid/20399839&rft_els_id=S030439401000457X&rfr_iscdi=true |