Closer correlation of cadmium in urine than that of cadmium in blood with tubular dysfunction markers in urine among general women populations in Japan
Objectives The objectives of the present study are to investigate whether cadmium in blood (Cd-B) and cadmium in urine (Cd-U) correlate with each other irrespective of age among general populations and which one of Cd-B or Cd-U correlates more closely with three renal tubular dysfunction markers in...
Gespeichert in:
| Veröffentlicht in: | International archives of occupational and environmental health 2011-02, Vol.84 (2), p.121-129 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 129 |
|---|---|
| container_issue | 2 |
| container_start_page | 121 |
| container_title | International archives of occupational and environmental health |
| container_volume | 84 |
| creator | Ikeda, Masayuki Ohashi, Fumiko Fukui, Yoshinari Sakuragi, Sonoko Moriguchi, Jiro |
| description | Objectives
The objectives of the present study are to investigate whether cadmium in blood (Cd-B) and cadmium in urine (Cd-U) correlate with each other irrespective of age among general populations and which one of Cd-B or Cd-U correlates more closely with three renal tubular dysfunction markers in urine of α
1
-microglobulin (α
1
-MG-U), β
2
-microglobulin (β
2
-MG-U) and
N
-acetyl-β-
d
-glucosaminidase (NAG-U).
Methods
Data on two exposure markers (Cd-B and Cd-U) and three effect markers (α
1
-MG-U, β
2
-MG-U and NAG-U) were collected for 1,403 adult women in non-polluted areas all over Japan. Possible significance of correlation between the parameters and dependency on age was examined by simple and multiple regression analysis.
Results
Both Cd-B and Cd-U increased as a function of age. The two exposure markers correlated significantly with each other, and the Cd-U over Cd-B ratio also increased as a function of age. Although both Cd-B and Cd-U correlated significantly with the three effect markers, the correlation was closer for Cd-U than for Cd-B.
Conclusions
Cd-U rather than Cd-B should be recommended as an exposure marker of choice in Cd biological monitoring of general populations. Effects of aging should be taken into account when evaluating study results. |
| doi_str_mv | 10.1007/s00420-010-0527-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_856785796</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2236629731</sourcerecordid><originalsourceid>FETCH-LOGICAL-c432t-606e610e568d4c783682275babe555510631826e0c9359afd3999470fde362f23</originalsourceid><addsrcrecordid>eNp1kc1u1DAUhS0EotPCA7BBFhJiFfBf7GSJRoWCKrGBteU4N9MUxw52rKpPwuviNAMjVcKS7cX97jnXPgi9ouQ9JUR9SIQIRipCy66ZqugTtKOCs4oyIZ-iHeFirXJ6hs5TuiWEKqn4c3TGCJeCSbVDv_cuJIjYhhjBmWUMHocBW9NPY57w6HGOowe83Bi_HsujaudC6PHduNzgJXfZmYj7-zRkbx-kJhN_QkwnHTMFf8AH8BCNw3dhAo_nMOfN-gH8ambjX6Bng3EJXh7vC_Tj0-X3_VV1_e3zl_3H68qWdy6VJBIkJVDLphdWNVw2jKm6Mx3UZVEiOW2YBGJbXrdm6HnbtkKRoQcu2cD4BXq36c4x_MqQFj2NyYJzxkPISTe1VE2tWlnIN4_I25CjL8PphrdMUFKLAtENsjGkFGHQcxzLJ9xrSvSamd4y0yUzvWamael5fRTO3QT9v46_IRXg7REwyRo3ROPtmE4cL_6iWTm2camU_AHiacL_u_8BMrCvNg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>839241054</pqid></control><display><type>article</type><title>Closer correlation of cadmium in urine than that of cadmium in blood with tubular dysfunction markers in urine among general women populations in Japan</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Ikeda, Masayuki ; Ohashi, Fumiko ; Fukui, Yoshinari ; Sakuragi, Sonoko ; Moriguchi, Jiro</creator><creatorcontrib>Ikeda, Masayuki ; Ohashi, Fumiko ; Fukui, Yoshinari ; Sakuragi, Sonoko ; Moriguchi, Jiro</creatorcontrib><description>Objectives
The objectives of the present study are to investigate whether cadmium in blood (Cd-B) and cadmium in urine (Cd-U) correlate with each other irrespective of age among general populations and which one of Cd-B or Cd-U correlates more closely with three renal tubular dysfunction markers in urine of α
1
-microglobulin (α
1
-MG-U), β
2
-microglobulin (β
2
-MG-U) and
N
-acetyl-β-
d
-glucosaminidase (NAG-U).
Methods
Data on two exposure markers (Cd-B and Cd-U) and three effect markers (α
1
-MG-U, β
2
-MG-U and NAG-U) were collected for 1,403 adult women in non-polluted areas all over Japan. Possible significance of correlation between the parameters and dependency on age was examined by simple and multiple regression analysis.
Results
Both Cd-B and Cd-U increased as a function of age. The two exposure markers correlated significantly with each other, and the Cd-U over Cd-B ratio also increased as a function of age. Although both Cd-B and Cd-U correlated significantly with the three effect markers, the correlation was closer for Cd-U than for Cd-B.
Conclusions
Cd-U rather than Cd-B should be recommended as an exposure marker of choice in Cd biological monitoring of general populations. Effects of aging should be taken into account when evaluating study results.</description><identifier>ISSN: 0340-0131</identifier><identifier>EISSN: 1432-1246</identifier><identifier>DOI: 10.1007/s00420-010-0527-1</identifier><identifier>PMID: 20364267</identifier><identifier>CODEN: IAEHDW</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Acetylglucosaminidase - urine ; Adult ; Age Factors ; Aged, 80 and over ; Alpha-Globulins - urine ; Analysis of Variance ; beta 2-Microglobulin - urine ; Biological and medical sciences ; Biomarkers ; Biomarkers - urine ; Biomonitoring ; Blood ; Cadmium ; Cadmium - blood ; Cadmium - urine ; Chemical and industrial products toxicology. Toxic occupational diseases ; Correlation analysis ; Creatinine - urine ; Earth and Environmental Science ; Environment ; Environmental Health ; Environmental Pollution ; Female ; Humans ; Japan ; Kidney Tubules - physiopathology ; Medical sciences ; Metals and various inorganic compounds ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Occupational Medicine/Industrial Medicine ; Original Article ; Regression Analysis ; Rehabilitation ; Renal function ; Spectrophotometry, Atomic ; Toxicology ; Tubulopathies ; Urine ; Women ; Young Adult</subject><ispartof>International archives of occupational and environmental health, 2011-02, Vol.84 (2), p.121-129</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-606e610e568d4c783682275babe555510631826e0c9359afd3999470fde362f23</citedby><cites>FETCH-LOGICAL-c432t-606e610e568d4c783682275babe555510631826e0c9359afd3999470fde362f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00420-010-0527-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00420-010-0527-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23839487$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20364267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ikeda, Masayuki</creatorcontrib><creatorcontrib>Ohashi, Fumiko</creatorcontrib><creatorcontrib>Fukui, Yoshinari</creatorcontrib><creatorcontrib>Sakuragi, Sonoko</creatorcontrib><creatorcontrib>Moriguchi, Jiro</creatorcontrib><title>Closer correlation of cadmium in urine than that of cadmium in blood with tubular dysfunction markers in urine among general women populations in Japan</title><title>International archives of occupational and environmental health</title><addtitle>Int Arch Occup Environ Health</addtitle><addtitle>Int Arch Occup Environ Health</addtitle><description>Objectives
The objectives of the present study are to investigate whether cadmium in blood (Cd-B) and cadmium in urine (Cd-U) correlate with each other irrespective of age among general populations and which one of Cd-B or Cd-U correlates more closely with three renal tubular dysfunction markers in urine of α
1
-microglobulin (α
1
-MG-U), β
2
-microglobulin (β
2
-MG-U) and
N
-acetyl-β-
d
-glucosaminidase (NAG-U).
Methods
Data on two exposure markers (Cd-B and Cd-U) and three effect markers (α
1
-MG-U, β
2
-MG-U and NAG-U) were collected for 1,403 adult women in non-polluted areas all over Japan. Possible significance of correlation between the parameters and dependency on age was examined by simple and multiple regression analysis.
Results
Both Cd-B and Cd-U increased as a function of age. The two exposure markers correlated significantly with each other, and the Cd-U over Cd-B ratio also increased as a function of age. Although both Cd-B and Cd-U correlated significantly with the three effect markers, the correlation was closer for Cd-U than for Cd-B.
Conclusions
Cd-U rather than Cd-B should be recommended as an exposure marker of choice in Cd biological monitoring of general populations. Effects of aging should be taken into account when evaluating study results.</description><subject>Acetylglucosaminidase - urine</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged, 80 and over</subject><subject>Alpha-Globulins - urine</subject><subject>Analysis of Variance</subject><subject>beta 2-Microglobulin - urine</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - urine</subject><subject>Biomonitoring</subject><subject>Blood</subject><subject>Cadmium</subject><subject>Cadmium - blood</subject><subject>Cadmium - urine</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Correlation analysis</subject><subject>Creatinine - urine</subject><subject>Earth and Environmental Science</subject><subject>Environment</subject><subject>Environmental Health</subject><subject>Environmental Pollution</subject><subject>Female</subject><subject>Humans</subject><subject>Japan</subject><subject>Kidney Tubules - physiopathology</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Regression Analysis</subject><subject>Rehabilitation</subject><subject>Renal function</subject><subject>Spectrophotometry, Atomic</subject><subject>Toxicology</subject><subject>Tubulopathies</subject><subject>Urine</subject><subject>Women</subject><subject>Young Adult</subject><issn>0340-0131</issn><issn>1432-1246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1u1DAUhS0EotPCA7BBFhJiFfBf7GSJRoWCKrGBteU4N9MUxw52rKpPwuviNAMjVcKS7cX97jnXPgi9ouQ9JUR9SIQIRipCy66ZqugTtKOCs4oyIZ-iHeFirXJ6hs5TuiWEKqn4c3TGCJeCSbVDv_cuJIjYhhjBmWUMHocBW9NPY57w6HGOowe83Bi_HsujaudC6PHduNzgJXfZmYj7-zRkbx-kJhN_QkwnHTMFf8AH8BCNw3dhAo_nMOfN-gH8ambjX6Bng3EJXh7vC_Tj0-X3_VV1_e3zl_3H68qWdy6VJBIkJVDLphdWNVw2jKm6Mx3UZVEiOW2YBGJbXrdm6HnbtkKRoQcu2cD4BXq36c4x_MqQFj2NyYJzxkPISTe1VE2tWlnIN4_I25CjL8PphrdMUFKLAtENsjGkFGHQcxzLJ9xrSvSamd4y0yUzvWamael5fRTO3QT9v46_IRXg7REwyRo3ROPtmE4cL_6iWTm2camU_AHiacL_u_8BMrCvNg</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Ikeda, Masayuki</creator><creator>Ohashi, Fumiko</creator><creator>Fukui, Yoshinari</creator><creator>Sakuragi, Sonoko</creator><creator>Moriguchi, Jiro</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7U2</scope></search><sort><creationdate>20110201</creationdate><title>Closer correlation of cadmium in urine than that of cadmium in blood with tubular dysfunction markers in urine among general women populations in Japan</title><author>Ikeda, Masayuki ; Ohashi, Fumiko ; Fukui, Yoshinari ; Sakuragi, Sonoko ; Moriguchi, Jiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-606e610e568d4c783682275babe555510631826e0c9359afd3999470fde362f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetylglucosaminidase - urine</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged, 80 and over</topic><topic>Alpha-Globulins - urine</topic><topic>Analysis of Variance</topic><topic>beta 2-Microglobulin - urine</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - urine</topic><topic>Biomonitoring</topic><topic>Blood</topic><topic>Cadmium</topic><topic>Cadmium - blood</topic><topic>Cadmium - urine</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Correlation analysis</topic><topic>Creatinine - urine</topic><topic>Earth and Environmental Science</topic><topic>Environment</topic><topic>Environmental Health</topic><topic>Environmental Pollution</topic><topic>Female</topic><topic>Humans</topic><topic>Japan</topic><topic>Kidney Tubules - physiopathology</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Regression Analysis</topic><topic>Rehabilitation</topic><topic>Renal function</topic><topic>Spectrophotometry, Atomic</topic><topic>Toxicology</topic><topic>Tubulopathies</topic><topic>Urine</topic><topic>Women</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ikeda, Masayuki</creatorcontrib><creatorcontrib>Ohashi, Fumiko</creatorcontrib><creatorcontrib>Fukui, Yoshinari</creatorcontrib><creatorcontrib>Sakuragi, Sonoko</creatorcontrib><creatorcontrib>Moriguchi, Jiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Safety Science and Risk</collection><jtitle>International archives of occupational and environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikeda, Masayuki</au><au>Ohashi, Fumiko</au><au>Fukui, Yoshinari</au><au>Sakuragi, Sonoko</au><au>Moriguchi, Jiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Closer correlation of cadmium in urine than that of cadmium in blood with tubular dysfunction markers in urine among general women populations in Japan</atitle><jtitle>International archives of occupational and environmental health</jtitle><stitle>Int Arch Occup Environ Health</stitle><addtitle>Int Arch Occup Environ Health</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>84</volume><issue>2</issue><spage>121</spage><epage>129</epage><pages>121-129</pages><issn>0340-0131</issn><eissn>1432-1246</eissn><coden>IAEHDW</coden><abstract>Objectives
The objectives of the present study are to investigate whether cadmium in blood (Cd-B) and cadmium in urine (Cd-U) correlate with each other irrespective of age among general populations and which one of Cd-B or Cd-U correlates more closely with three renal tubular dysfunction markers in urine of α
1
-microglobulin (α
1
-MG-U), β
2
-microglobulin (β
2
-MG-U) and
N
-acetyl-β-
d
-glucosaminidase (NAG-U).
Methods
Data on two exposure markers (Cd-B and Cd-U) and three effect markers (α
1
-MG-U, β
2
-MG-U and NAG-U) were collected for 1,403 adult women in non-polluted areas all over Japan. Possible significance of correlation between the parameters and dependency on age was examined by simple and multiple regression analysis.
Results
Both Cd-B and Cd-U increased as a function of age. The two exposure markers correlated significantly with each other, and the Cd-U over Cd-B ratio also increased as a function of age. Although both Cd-B and Cd-U correlated significantly with the three effect markers, the correlation was closer for Cd-U than for Cd-B.
Conclusions
Cd-U rather than Cd-B should be recommended as an exposure marker of choice in Cd biological monitoring of general populations. Effects of aging should be taken into account when evaluating study results.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20364267</pmid><doi>10.1007/s00420-010-0527-1</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-0131 |
| ispartof | International archives of occupational and environmental health, 2011-02, Vol.84 (2), p.121-129 |
| issn | 0340-0131 1432-1246 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_856785796 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Acetylglucosaminidase - urine Adult Age Factors Aged, 80 and over Alpha-Globulins - urine Analysis of Variance beta 2-Microglobulin - urine Biological and medical sciences Biomarkers Biomarkers - urine Biomonitoring Blood Cadmium Cadmium - blood Cadmium - urine Chemical and industrial products toxicology. Toxic occupational diseases Correlation analysis Creatinine - urine Earth and Environmental Science Environment Environmental Health Environmental Pollution Female Humans Japan Kidney Tubules - physiopathology Medical sciences Metals and various inorganic compounds Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Occupational Medicine/Industrial Medicine Original Article Regression Analysis Rehabilitation Renal function Spectrophotometry, Atomic Toxicology Tubulopathies Urine Women Young Adult |
| title | Closer correlation of cadmium in urine than that of cadmium in blood with tubular dysfunction markers in urine among general women populations in Japan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T21%3A39%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Closer%20correlation%20of%20cadmium%20in%20urine%20than%20that%20of%20cadmium%20in%20blood%20with%20tubular%20dysfunction%20markers%20in%20urine%20among%20general%20women%20populations%20in%20Japan&rft.jtitle=International%20archives%20of%20occupational%20and%20environmental%20health&rft.au=Ikeda,%20Masayuki&rft.date=2011-02-01&rft.volume=84&rft.issue=2&rft.spage=121&rft.epage=129&rft.pages=121-129&rft.issn=0340-0131&rft.eissn=1432-1246&rft.coden=IAEHDW&rft_id=info:doi/10.1007/s00420-010-0527-1&rft_dat=%3Cproquest_cross%3E2236629731%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=839241054&rft_id=info:pmid/20364267&rfr_iscdi=true |