Clinical Significance of Slow Recovery of Graft Function in Living Donor Kidney Transplantation
The clinical significance of slow recovery of graft function (SGF) in living donor kidney transplantation is unclear. We evaluated the incidence, risk factors, and clinical outcome of SGF in living donor transplantation. Three hundred ten living donor kidney recipients were included and categorized...
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Veröffentlicht in: | Transplantation 2010-07, Vol.90 (1), p.38-43 |
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creator | SO YOUNG LEE BYUNG HA CHUNG IN SUNG MOON KIM, Yong-Soo YEONG JIN CHOI CHUL WOO YANG SHANG GUO PIAO SEOK HUI KANG BOK JIN HYOUNG YOUN JOO JEON HYEON SEOK HWANG HYE EUN YOON BUM SOON CHOI KIM, Ji-Il |
description | The clinical significance of slow recovery of graft function (SGF) in living donor kidney transplantation is unclear. We evaluated the incidence, risk factors, and clinical outcome of SGF in living donor transplantation.
Three hundred ten living donor kidney recipients were included and categorized into immediate recovery of graft function (IGF; n=239) and SGF (n=71), according to estimated glomerular filtration rate (60 mL/min/1.73 m) at posttransplant day 14. We compared the clinical parameters, protocol biopsy findings, acute rejection (AR), and 10-year graft survival between the two groups.
The SGF group had an older recipient age, lower ratio of donor to recipient body mass index, and higher incidence of AR than IGF group, as shown by protocol biopsies. The SGF group had significantly more AR episodes than IGF group within 12 months (21.1% vs. 13.4%, P |
doi_str_mv | 10.1097/tp.0b013e3181e065a2 |
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Three hundred ten living donor kidney recipients were included and categorized into immediate recovery of graft function (IGF; n=239) and SGF (n=71), according to estimated glomerular filtration rate (60 mL/min/1.73 m) at posttransplant day 14. We compared the clinical parameters, protocol biopsy findings, acute rejection (AR), and 10-year graft survival between the two groups.
The SGF group had an older recipient age, lower ratio of donor to recipient body mass index, and higher incidence of AR than IGF group, as shown by protocol biopsies. The SGF group had significantly more AR episodes than IGF group within 12 months (21.1% vs. 13.4%, P<0.05) and during follow-up period (32.4% vs. 20.1%, P<0.05). The 10-year graft survival rate did not differ between groups, but AR presence was significantly associated with a lower graft survival in the SGF group than the IGF group (64.9% vs. 78.9%, P<0.05).
SGF in the early posttransplant period is immunologically active and should be considered as one of the risk factors for determining long-term graft survival in living donor kidney transplantation.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/tp.0b013e3181e065a2</identifier><identifier>PMID: 20531075</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Acute Disease ; Adult ; Biological and medical sciences ; Biopsy ; Creatinine - blood ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Glomerular Filtration Rate ; Graft Rejection - epidemiology ; Graft Rejection - pathology ; Graft Survival - physiology ; Humans ; Kidney Transplantation - pathology ; Kidney Transplantation - physiology ; Living Donors ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Patient Selection ; Retrospective Studies ; Risk Factors ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Survivors - statistics & numerical data ; Time Factors ; Tissue Donors - statistics & numerical data ; Tissue, organ and graft immunology ; Treatment Outcome</subject><ispartof>Transplantation, 2010-07, Vol.90 (1), p.38-43</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-3a7bf37e1bc14436f11b41dc8dc6c6b1ea86d7514d2d300e5e28cfbf27bc32603</citedby><cites>FETCH-LOGICAL-c477t-3a7bf37e1bc14436f11b41dc8dc6c6b1ea86d7514d2d300e5e28cfbf27bc32603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23019450$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20531075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SO YOUNG LEE</creatorcontrib><creatorcontrib>BYUNG HA CHUNG</creatorcontrib><creatorcontrib>IN SUNG MOON</creatorcontrib><creatorcontrib>KIM, Yong-Soo</creatorcontrib><creatorcontrib>YEONG JIN CHOI</creatorcontrib><creatorcontrib>CHUL WOO YANG</creatorcontrib><creatorcontrib>SHANG GUO PIAO</creatorcontrib><creatorcontrib>SEOK HUI KANG</creatorcontrib><creatorcontrib>BOK JIN HYOUNG</creatorcontrib><creatorcontrib>YOUN JOO JEON</creatorcontrib><creatorcontrib>HYEON SEOK HWANG</creatorcontrib><creatorcontrib>HYE EUN YOON</creatorcontrib><creatorcontrib>BUM SOON CHOI</creatorcontrib><creatorcontrib>KIM, Ji-Il</creatorcontrib><title>Clinical Significance of Slow Recovery of Graft Function in Living Donor Kidney Transplantation</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>The clinical significance of slow recovery of graft function (SGF) in living donor kidney transplantation is unclear. We evaluated the incidence, risk factors, and clinical outcome of SGF in living donor transplantation.
Three hundred ten living donor kidney recipients were included and categorized into immediate recovery of graft function (IGF; n=239) and SGF (n=71), according to estimated glomerular filtration rate (60 mL/min/1.73 m) at posttransplant day 14. We compared the clinical parameters, protocol biopsy findings, acute rejection (AR), and 10-year graft survival between the two groups.
The SGF group had an older recipient age, lower ratio of donor to recipient body mass index, and higher incidence of AR than IGF group, as shown by protocol biopsies. The SGF group had significantly more AR episodes than IGF group within 12 months (21.1% vs. 13.4%, P<0.05) and during follow-up period (32.4% vs. 20.1%, P<0.05). The 10-year graft survival rate did not differ between groups, but AR presence was significantly associated with a lower graft survival in the SGF group than the IGF group (64.9% vs. 78.9%, P<0.05).
SGF in the early posttransplant period is immunologically active and should be considered as one of the risk factors for determining long-term graft survival in living donor kidney transplantation.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Glomerular Filtration Rate</subject><subject>Graft Rejection - epidemiology</subject><subject>Graft Rejection - pathology</subject><subject>Graft Survival - physiology</subject><subject>Humans</subject><subject>Kidney Transplantation - pathology</subject><subject>Kidney Transplantation - physiology</subject><subject>Living Donors</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Patient Selection</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>Survivors - statistics & numerical data</subject><subject>Time Factors</subject><subject>Tissue Donors - statistics & numerical data</subject><subject>Tissue, organ and graft immunology</subject><subject>Treatment Outcome</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFPGzEQhS1UBGngF1SqfKl6WpjZ8drLEYUCFZFAEM4rr9dGrjZ2sDdU-ffdiBQkLpzmafS90eg9xr4hnCCcqdNhdQItIFnCGi3ISpd7bIIViUJCDV_YBEBggUTqkH3N-Q8AVKTUATssR4GgqglrZr0P3uieP_in4N0og7E8Ov7Qx7_83pr4YtNmu7hK2g38ch3M4GPgPvC5f_HhiV_EEBO_8V2wG75IOuRVr8Ogt9gR23e6z_Z4N6fs8fLXYnZdzG-vfs_O54URSg0FadU6UhZbg0KQdIitwM7UnZFGtmh1LTtVoejKjgBsZcvauNaVqjVUSqAp-_l6d5Xi89rmoVn6bGw_PmLjOjd1JVVNRPgpqYikwO0XU0avpEkx52Rds0p-qdOmQWi2FTSLu-ZjBaPr--7-ul3a7s3zP_MR-LEDdB6Dd2Ngxud3jgDPRAX0D9BgkAA</recordid><startdate>20100715</startdate><enddate>20100715</enddate><creator>SO YOUNG LEE</creator><creator>BYUNG HA CHUNG</creator><creator>IN SUNG MOON</creator><creator>KIM, Yong-Soo</creator><creator>YEONG JIN CHOI</creator><creator>CHUL WOO YANG</creator><creator>SHANG GUO PIAO</creator><creator>SEOK HUI KANG</creator><creator>BOK JIN HYOUNG</creator><creator>YOUN JOO JEON</creator><creator>HYEON SEOK HWANG</creator><creator>HYE EUN YOON</creator><creator>BUM SOON CHOI</creator><creator>KIM, Ji-Il</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20100715</creationdate><title>Clinical Significance of Slow Recovery of Graft Function in Living Donor Kidney Transplantation</title><author>SO YOUNG LEE ; BYUNG HA CHUNG ; IN SUNG MOON ; KIM, Yong-Soo ; YEONG JIN CHOI ; CHUL WOO YANG ; SHANG GUO PIAO ; SEOK HUI KANG ; BOK JIN HYOUNG ; YOUN JOO JEON ; HYEON SEOK HWANG ; HYE EUN YOON ; BUM SOON CHOI ; KIM, Ji-Il</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-3a7bf37e1bc14436f11b41dc8dc6c6b1ea86d7514d2d300e5e28cfbf27bc32603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Glomerular Filtration Rate</topic><topic>Graft Rejection - epidemiology</topic><topic>Graft Rejection - pathology</topic><topic>Graft Survival - physiology</topic><topic>Humans</topic><topic>Kidney Transplantation - pathology</topic><topic>Kidney Transplantation - physiology</topic><topic>Living Donors</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Patient Selection</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>Survivors - statistics & numerical data</topic><topic>Time Factors</topic><topic>Tissue Donors - statistics & numerical data</topic><topic>Tissue, organ and graft immunology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SO YOUNG LEE</creatorcontrib><creatorcontrib>BYUNG HA CHUNG</creatorcontrib><creatorcontrib>IN SUNG MOON</creatorcontrib><creatorcontrib>KIM, Yong-Soo</creatorcontrib><creatorcontrib>YEONG JIN CHOI</creatorcontrib><creatorcontrib>CHUL WOO YANG</creatorcontrib><creatorcontrib>SHANG GUO PIAO</creatorcontrib><creatorcontrib>SEOK HUI KANG</creatorcontrib><creatorcontrib>BOK JIN HYOUNG</creatorcontrib><creatorcontrib>YOUN JOO JEON</creatorcontrib><creatorcontrib>HYEON SEOK HWANG</creatorcontrib><creatorcontrib>HYE EUN YOON</creatorcontrib><creatorcontrib>BUM SOON CHOI</creatorcontrib><creatorcontrib>KIM, Ji-Il</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SO YOUNG LEE</au><au>BYUNG HA CHUNG</au><au>IN SUNG MOON</au><au>KIM, Yong-Soo</au><au>YEONG JIN CHOI</au><au>CHUL WOO YANG</au><au>SHANG GUO PIAO</au><au>SEOK HUI KANG</au><au>BOK JIN HYOUNG</au><au>YOUN JOO JEON</au><au>HYEON SEOK HWANG</au><au>HYE EUN YOON</au><au>BUM SOON CHOI</au><au>KIM, Ji-Il</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Significance of Slow Recovery of Graft Function in Living Donor Kidney Transplantation</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2010-07-15</date><risdate>2010</risdate><volume>90</volume><issue>1</issue><spage>38</spage><epage>43</epage><pages>38-43</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>The clinical significance of slow recovery of graft function (SGF) in living donor kidney transplantation is unclear. We evaluated the incidence, risk factors, and clinical outcome of SGF in living donor transplantation.
Three hundred ten living donor kidney recipients were included and categorized into immediate recovery of graft function (IGF; n=239) and SGF (n=71), according to estimated glomerular filtration rate (60 mL/min/1.73 m) at posttransplant day 14. We compared the clinical parameters, protocol biopsy findings, acute rejection (AR), and 10-year graft survival between the two groups.
The SGF group had an older recipient age, lower ratio of donor to recipient body mass index, and higher incidence of AR than IGF group, as shown by protocol biopsies. The SGF group had significantly more AR episodes than IGF group within 12 months (21.1% vs. 13.4%, P<0.05) and during follow-up period (32.4% vs. 20.1%, P<0.05). The 10-year graft survival rate did not differ between groups, but AR presence was significantly associated with a lower graft survival in the SGF group than the IGF group (64.9% vs. 78.9%, P<0.05).
SGF in the early posttransplant period is immunologically active and should be considered as one of the risk factors for determining long-term graft survival in living donor kidney transplantation.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>20531075</pmid><doi>10.1097/tp.0b013e3181e065a2</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Acute Disease Adult Biological and medical sciences Biopsy Creatinine - blood Female Fundamental and applied biological sciences. Psychology Fundamental immunology Glomerular Filtration Rate Graft Rejection - epidemiology Graft Rejection - pathology Graft Survival - physiology Humans Kidney Transplantation - pathology Kidney Transplantation - physiology Living Donors Male Medical sciences Middle Aged Multivariate Analysis Patient Selection Retrospective Studies Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Survivors - statistics & numerical data Time Factors Tissue Donors - statistics & numerical data Tissue, organ and graft immunology Treatment Outcome |
title | Clinical Significance of Slow Recovery of Graft Function in Living Donor Kidney Transplantation |
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