Clinical Significance of Slow Recovery of Graft Function in Living Donor Kidney Transplantation

The clinical significance of slow recovery of graft function (SGF) in living donor kidney transplantation is unclear. We evaluated the incidence, risk factors, and clinical outcome of SGF in living donor transplantation. Three hundred ten living donor kidney recipients were included and categorized...

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Veröffentlicht in:Transplantation 2010-07, Vol.90 (1), p.38-43
Hauptverfasser: SO YOUNG LEE, BYUNG HA CHUNG, IN SUNG MOON, KIM, Yong-Soo, YEONG JIN CHOI, CHUL WOO YANG, SHANG GUO PIAO, SEOK HUI KANG, BOK JIN HYOUNG, YOUN JOO JEON, HYEON SEOK HWANG, HYE EUN YOON, BUM SOON CHOI, KIM, Ji-Il
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container_end_page 43
container_issue 1
container_start_page 38
container_title Transplantation
container_volume 90
creator SO YOUNG LEE
BYUNG HA CHUNG
IN SUNG MOON
KIM, Yong-Soo
YEONG JIN CHOI
CHUL WOO YANG
SHANG GUO PIAO
SEOK HUI KANG
BOK JIN HYOUNG
YOUN JOO JEON
HYEON SEOK HWANG
HYE EUN YOON
BUM SOON CHOI
KIM, Ji-Il
description The clinical significance of slow recovery of graft function (SGF) in living donor kidney transplantation is unclear. We evaluated the incidence, risk factors, and clinical outcome of SGF in living donor transplantation. Three hundred ten living donor kidney recipients were included and categorized into immediate recovery of graft function (IGF; n=239) and SGF (n=71), according to estimated glomerular filtration rate (60 mL/min/1.73 m) at posttransplant day 14. We compared the clinical parameters, protocol biopsy findings, acute rejection (AR), and 10-year graft survival between the two groups. The SGF group had an older recipient age, lower ratio of donor to recipient body mass index, and higher incidence of AR than IGF group, as shown by protocol biopsies. The SGF group had significantly more AR episodes than IGF group within 12 months (21.1% vs. 13.4%, P
doi_str_mv 10.1097/tp.0b013e3181e065a2
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We evaluated the incidence, risk factors, and clinical outcome of SGF in living donor transplantation. Three hundred ten living donor kidney recipients were included and categorized into immediate recovery of graft function (IGF; n=239) and SGF (n=71), according to estimated glomerular filtration rate (60 mL/min/1.73 m) at posttransplant day 14. We compared the clinical parameters, protocol biopsy findings, acute rejection (AR), and 10-year graft survival between the two groups. The SGF group had an older recipient age, lower ratio of donor to recipient body mass index, and higher incidence of AR than IGF group, as shown by protocol biopsies. The SGF group had significantly more AR episodes than IGF group within 12 months (21.1% vs. 13.4%, P&lt;0.05) and during follow-up period (32.4% vs. 20.1%, P&lt;0.05). The 10-year graft survival rate did not differ between groups, but AR presence was significantly associated with a lower graft survival in the SGF group than the IGF group (64.9% vs. 78.9%, P&lt;0.05). SGF in the early posttransplant period is immunologically active and should be considered as one of the risk factors for determining long-term graft survival in living donor kidney transplantation.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/tp.0b013e3181e065a2</identifier><identifier>PMID: 20531075</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams &amp; Wilkins</publisher><subject>Acute Disease ; Adult ; Biological and medical sciences ; Biopsy ; Creatinine - blood ; Female ; Fundamental and applied biological sciences. 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The 10-year graft survival rate did not differ between groups, but AR presence was significantly associated with a lower graft survival in the SGF group than the IGF group (64.9% vs. 78.9%, P&lt;0.05). SGF in the early posttransplant period is immunologically active and should be considered as one of the risk factors for determining long-term graft survival in living donor kidney transplantation.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. 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We evaluated the incidence, risk factors, and clinical outcome of SGF in living donor transplantation. Three hundred ten living donor kidney recipients were included and categorized into immediate recovery of graft function (IGF; n=239) and SGF (n=71), according to estimated glomerular filtration rate (60 mL/min/1.73 m) at posttransplant day 14. We compared the clinical parameters, protocol biopsy findings, acute rejection (AR), and 10-year graft survival between the two groups. The SGF group had an older recipient age, lower ratio of donor to recipient body mass index, and higher incidence of AR than IGF group, as shown by protocol biopsies. The SGF group had significantly more AR episodes than IGF group within 12 months (21.1% vs. 13.4%, P&lt;0.05) and during follow-up period (32.4% vs. 20.1%, P&lt;0.05). The 10-year graft survival rate did not differ between groups, but AR presence was significantly associated with a lower graft survival in the SGF group than the IGF group (64.9% vs. 78.9%, P&lt;0.05). SGF in the early posttransplant period is immunologically active and should be considered as one of the risk factors for determining long-term graft survival in living donor kidney transplantation.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams &amp; Wilkins</pub><pmid>20531075</pmid><doi>10.1097/tp.0b013e3181e065a2</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Acute Disease
Adult
Biological and medical sciences
Biopsy
Creatinine - blood
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Glomerular Filtration Rate
Graft Rejection - epidemiology
Graft Rejection - pathology
Graft Survival - physiology
Humans
Kidney Transplantation - pathology
Kidney Transplantation - physiology
Living Donors
Male
Medical sciences
Middle Aged
Multivariate Analysis
Patient Selection
Retrospective Studies
Risk Factors
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Survivors - statistics & numerical data
Time Factors
Tissue Donors - statistics & numerical data
Tissue, organ and graft immunology
Treatment Outcome
title Clinical Significance of Slow Recovery of Graft Function in Living Donor Kidney Transplantation
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