Potent Antirheumatic Activity of a New DNA Vaccine Targeted to B7-2/CD28 Costimulatory Signaling Pathway in Autoimmune Arthritis

Rheumatoid arthritis is a proinflammatory autoimmune disease attributed to failure of both CD4(+)CD25(+) regulatory T (Tr) and CD8(+)CD28(-) suppressor T (Ts) cells to control autoreactive CD4(+)CD28(+) Th1 (Th1) and autoantibody-producing B cells. Here we show a single intramuscular injection of ou...

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Veröffentlicht in:	Human gene therapy 2011, Vol.22 (1), p.65-76
Hauptverfasser:	Xue, Hong, Liang, Fei, Liu, Nan, Song, Xinqiang, Yuan, Fang, Luo, Yuan, Zhao, Xiao, Long, Juan, Sun, Yuying, Xi, Yongzhi
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP Ribose Transferases - administration & dosage ADP Ribose Transferases - immunology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antirheumatic Agents - immunology Antirheumatic Agents - metabolism Applied cell therapy and gene therapy Arthritis, Experimental - immunology Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - prevention & control B7-2 Antigen - administration & dosage B7-2 Antigen - immunology Bacterial Toxins - administration & dosage Bacterial Toxins - immunology Biological and medical sciences Biotechnology CD28 Antigens - immunology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell physiology Cytokines - immunology Exotoxins - administration & dosage Exotoxins - immunology Female Fundamental and applied biological sciences. Psychology Gene therapy Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Medical sciences Molecular and cellular biology Pseudomonas Pseudomonas aeruginosa Exotoxin A Rats Rats, Wistar Signal Transduction T-Lymphocytes, Regulatory - immunology Th1 Cells - immunology Th2 Cells - immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Vaccines, DNA - immunology Vaccines, DNA - metabolism Virulence Factors - administration & dosage Virulence Factors - immunology
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