Diannexin Decreases Inflammatory Cell Infiltration Into the Islet Graft, Reduces β-Cell Apoptosis, and Improves Early Graft Function

A major unmet challenge is to reduce the islet mass needed for insulin independence in type 1 diabetic recipients after islet transplantation. The recombinant homodimer of human annexin V, diannexin, has completed a Phase II Clinical Trial in Kidney Transplantation (NCT00615966). We developed a marg...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Transplantation 2010-10, Vol.90 (7), p.709-716
Hauptverfasser:	CHENG, Elaine Y, SHARMA, Vijay K, CHANG, Christina, RUCHUANG DING, ALLISON, Anthony C, LEESER, David B, SUTHANTHIRAN, Manikkam, HUA YANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A5 - physiology Annexin A5 - therapeutic use Apoptosis Biological and medical sciences Diabetes Mellitus - surgery Diabetes Mellitus, Experimental - surgery Diabetes Mellitus, Type 1 - surgery Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Survival - drug effects Heme Oxygenase-1 - genetics Humans Inflammation - prevention & control Insulin-Secreting Cells - cytology Insulin-Secreting Cells - physiology Islets of Langerhans Transplantation - physiology Medical sciences Mice Mice, Inbred BALB C Models, Biological Polymerase Chain Reaction RNA, Messenger - genetics Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!