1,2-Naphthoquinone suppresses lipopolysaccharide-dependent activation of IKKβ/NF-κB/NO signaling: an alternative mechanism for the disturbance of inducible NO synthase-catalyzed NO formation

1,2-Naphthoquinone (1,2-NQ) is an uncoupling agent for constitutive nitric oxide (NO) synthase (NOS), thereby inhibiting its catalytic activity. However, little information on whether this quinone can affect inducible NOS (iNOS) is available. To address this issue, we examined the effect of 1,2-NQ o...

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Veröffentlicht in:	Journal of toxicological sciences 2010/12/01, Vol.35(6), pp.891-898
Hauptverfasser:	Sumi, Daigo, Akimori, Masako, Inoue, Ken-ichiro, Takano, Hirohisa, Kumagai, Yoshito
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Culture Techniques Cell Line Electrophile Electrophoretic Mobility Shift Assay I-kappa B Kinase - antagonists & inhibitors I-kappa B Kinase - genetics I-kappa B Kinase - metabolism IKKβ Immunoprecipitation Lipopolysaccharides - pharmacology Lung - drug effects Lung - enzymology Lung - metabolism Macrophages - drug effects Macrophages - enzymology Macrophages - metabolism Mice Mice, Inbred ICR Naphthoquinones - toxicity NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-κB Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - metabolism Signal Transduction Transfection
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