HLA‐B1511 is a risk factor for carbamazepine‐induced Stevens‐Johnson syndrome and toxic epidermal necrolysis in Japanese patients

Summary Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life‐threatening severe cutaneous adverse reactions. Recently, strong associations of HLA‐B*1502 with carbamazepine‐induced SJS/TEN have been found in Han Chinese patients. These associations have been confirmed...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2010-12, Vol.51 (12), p.2461-2465
Hauptverfasser:	Kaniwa, Nahoko, Saito, Yoshiro, Aihara, Michiko, Matsunaga, Kayoko, Tohkin, Masahiro, Kurose, Kouichi, Furuya, Hirokazu, Takahashi, Yukitoshi, Muramatsu, Masaaki, Kinoshita, Shigeru, Abe, Masamichi, Ikeda, Hiroko, Kashiwagi, Mariko, Song, Yixuan, Ueta, Mayumi, Sotozono, Chie, Ikezawa, Zenro, Hasegawa, Ryuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anticonvulsants. Antiepileptics. Antiparkinson agents Asian Continental Ancestry Group - genetics Biological and medical sciences Carbamazepine - adverse effects Carbamazepine - therapeutic use Child Family Female Genotype Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy HLA-B Antigens - genetics HLA-B15 Antigen HLA‐B1502 HLA‐B75 Humans Indexing in process India Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pharmacogenetics Pharmacology. Drug treatments Risk Factors Serotype Stevens-Johnson Syndrome - genetics Thailand
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