Association of variants within APOE, SORL1, RUNX1, BACE1 and ALDH18A1 with dementia in Alzheimer's disease in subjects with Down syndrome

▶ Significant associations of SNPs in five genes were found with dementia in Alzheimer's disease in Down syndrome. ▶ The most strongly associated SNP was the APOE ɛ4 rs429358. ▶ Variants within the more recently implicated SORL1 and RUNX1 genes were also strongly associated. ▶ A further five SN...

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Veröffentlicht in:	Neuroscience letters 2011-01, Vol.487 (2), p.144-148
Hauptverfasser:	Patel, Ashok, Rees, Simon D., Kelly, M. Ann, Bain, Steven C., Barnett, Anthony H., Thalitaya, Deepak, Prasher, Vee P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aldehyde Dehydrogenase - genetics Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Amyloid Precursor Protein Secretases - genetics APOE Apolipoprotein E4 - genetics Aspartic Acid Endopeptidases - genetics Biological and medical sciences Cohort Studies Core Binding Factor Alpha 2 Subunit - genetics Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Dementia - genetics Dementia - metabolism Down syndrome Down Syndrome - genetics Down Syndrome - metabolism Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Genetic Association Studies Genetic Variation - genetics Humans LDL-Receptor Related Proteins - genetics Male Medical sciences Membrane Transport Proteins - genetics Middle Aged Neurology Polymorphism, Single Nucleotide - genetics SNPs Vertebrates: nervous system and sense organs
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