Repeated rat-forced swim test: Reducing the number of animals to evaluate gradual effects of antidepressants

[Display omitted] ▶ Repeated rat-forced swim test detected gradual increase in the efficacy of low doses of fluoxetine. ▶ Repeated rat-forced swim test discriminated short and long-term effects of low doses of fluoxetine. ▶ Repeated rat-forced swim test reduced the number of rats required to evaluat...

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Veröffentlicht in:	Journal of neuroscience methods 2011-02, Vol.195 (2), p.200-205
Hauptverfasser:	Mezadri, T.J., Batista, G.M., Portes, A.C., Marino-Neto, J., Lino-de-Oliveira, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antidepressant drugs Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Behavior, Animal - drug effects Depression Depression - drug therapy Disease Models, Animal Drug Administration Schedule Ethological analysis Fluoxetine - pharmacology Fluoxetine - therapeutic use Immobility Response, Tonic - drug effects Male Principal Component Analysis Rats Rats, Wistar Reaction Time - drug effects Swimming - psychology Time Factors Uncontrollable stress
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