High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task
▶ High fat feeding (HFF) reduces peripheral insulin sensitivity in out-bred rats. ▶ HFF impairs an operant, but not a watermaze, delayed matching to position task. ▶ Effect of HFF is greater when the rule is switched from matching to non-matching. ▶ Cognitive deficit correlates with insulin sensitiv...
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| creator | McNeilly, Alison D. Williamson, Ritchie Sutherland, Calum Balfour, David J.K. Stewart, Caroline A. |
| description | ▶ High fat feeding (HFF) reduces peripheral insulin sensitivity in out-bred rats. ▶ HFF impairs an operant, but not a watermaze, delayed matching to position task. ▶ Effect of HFF is greater when the rule is switched from matching to non-matching. ▶ Cognitive deficit correlates with insulin sensitivity but not body weight.
Obesity is the single greatest risk factor for the development of Type 2 diabetes mellitus (T2DM), with the prevalence of both dramatically increasing in recent years. These conditions are associated with medical complications such as hypertension, neuropathy and cardiovascular disease. Recent evidence also suggests a greater risk of developing dementia including Alzheimer's disease. The molecular mechanisms governing these changes remain obscure, although epidemiological evidence suggests that reduced insulin sensitivity (a characteristic of T2DM) is an independent risk factor for Alzheimer's disease. Here we examine the effects of diet-induced insulin resistance on cognitive ability in an animal model not predisposed to develop Alzheimer's pathology. Following 12 weeks on a high fat diet (45% of calories as crude fat) male Wistar rats were overweight and insulin resistant but not frankly diabetic. High fat fed animals were consistently poorer in all aspects of an operant based delayed matching to position task, yet were not impaired in spatial working memory as judged by the open field watermaze test. The cognitive deficit of the HF fed animals was most apparent when the task was switched from matching to non-matching to position, suggestive of an inability to change contingency. Performance in this task was negatively correlated with whole body insulin sensitivity but not weight gain. In conclusion this study has shown that insulin resistant animals exhibit impairments in an operant measure of behavioural flexibility which precede the development of diabetes. |
| doi_str_mv | 10.1016/j.bbr.2010.10.017 |
| format | Article |
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Obesity is the single greatest risk factor for the development of Type 2 diabetes mellitus (T2DM), with the prevalence of both dramatically increasing in recent years. These conditions are associated with medical complications such as hypertension, neuropathy and cardiovascular disease. Recent evidence also suggests a greater risk of developing dementia including Alzheimer's disease. The molecular mechanisms governing these changes remain obscure, although epidemiological evidence suggests that reduced insulin sensitivity (a characteristic of T2DM) is an independent risk factor for Alzheimer's disease. Here we examine the effects of diet-induced insulin resistance on cognitive ability in an animal model not predisposed to develop Alzheimer's pathology. Following 12 weeks on a high fat diet (45% of calories as crude fat) male Wistar rats were overweight and insulin resistant but not frankly diabetic. High fat fed animals were consistently poorer in all aspects of an operant based delayed matching to position task, yet were not impaired in spatial working memory as judged by the open field watermaze test. The cognitive deficit of the HF fed animals was most apparent when the task was switched from matching to non-matching to position, suggestive of an inability to change contingency. Performance in this task was negatively correlated with whole body insulin sensitivity but not weight gain. In conclusion this study has shown that insulin resistant animals exhibit impairments in an operant measure of behavioural flexibility which precede the development of diabetes.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2010.10.017</identifier><identifier>PMID: 20974195</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Blood Glucose - metabolism ; Cognition - drug effects ; Conditioning, Operant - drug effects ; Diabetes ; Diabetes. Impaired glucose tolerance ; Diet ; Dietary Fats - pharmacology ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fundamental and applied biological sciences. Psychology ; Glucose ; Insulin - blood ; Insulin Resistance ; Locomotor activity ; Male ; Maze Learning - drug effects ; Medical sciences ; Motor Activity - drug effects ; Operant ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Wistar ; Reinforcement Schedule ; Watermaze</subject><ispartof>Behavioural brain research, 2011-02, Vol.217 (1), p.134-141</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-4de821b2a93ebf17dedeafe5a70ab2e1f2dccf4ae58074d350d0e918c58341173</citedby><cites>FETCH-LOGICAL-c414t-4de821b2a93ebf17dedeafe5a70ab2e1f2dccf4ae58074d350d0e918c58341173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0166432810006893$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23703729$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20974195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McNeilly, Alison D.</creatorcontrib><creatorcontrib>Williamson, Ritchie</creatorcontrib><creatorcontrib>Sutherland, Calum</creatorcontrib><creatorcontrib>Balfour, David J.K.</creatorcontrib><creatorcontrib>Stewart, Caroline A.</creatorcontrib><title>High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>▶ High fat feeding (HFF) reduces peripheral insulin sensitivity in out-bred rats. ▶ HFF impairs an operant, but not a watermaze, delayed matching to position task. ▶ Effect of HFF is greater when the rule is switched from matching to non-matching. ▶ Cognitive deficit correlates with insulin sensitivity but not body weight.
Obesity is the single greatest risk factor for the development of Type 2 diabetes mellitus (T2DM), with the prevalence of both dramatically increasing in recent years. These conditions are associated with medical complications such as hypertension, neuropathy and cardiovascular disease. Recent evidence also suggests a greater risk of developing dementia including Alzheimer's disease. The molecular mechanisms governing these changes remain obscure, although epidemiological evidence suggests that reduced insulin sensitivity (a characteristic of T2DM) is an independent risk factor for Alzheimer's disease. Here we examine the effects of diet-induced insulin resistance on cognitive ability in an animal model not predisposed to develop Alzheimer's pathology. Following 12 weeks on a high fat diet (45% of calories as crude fat) male Wistar rats were overweight and insulin resistant but not frankly diabetic. High fat fed animals were consistently poorer in all aspects of an operant based delayed matching to position task, yet were not impaired in spatial working memory as judged by the open field watermaze test. The cognitive deficit of the HF fed animals was most apparent when the task was switched from matching to non-matching to position, suggestive of an inability to change contingency. Performance in this task was negatively correlated with whole body insulin sensitivity but not weight gain. In conclusion this study has shown that insulin resistant animals exhibit impairments in an operant measure of behavioural flexibility which precede the development of diabetes.</description><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Cognition - drug effects</subject><subject>Conditioning, Operant - drug effects</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diet</subject><subject>Dietary Fats - pharmacology</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Locomotor activity</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Medical sciences</subject><subject>Motor Activity - drug effects</subject><subject>Operant</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reinforcement Schedule</subject><subject>Watermaze</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFCEQx4nRuLOrD-DFcDGeegQahu54Mpt112QTL3omNBSzjN0wAr3JPImvKz0zrjdNSIqq_Orzj9AbStaU0M2H3XoY0pqRo78mVD5DK9pJ1kjB--doVZlNw1vWXaDLnHeEEE4EfYkuGOklp71YoV93fvuAnS7YAVgftnif4hQLZJz9NI9FB4hzxhbM6ANgH-rLc_3jDCH74h99OWAdLDZxGxYf8B6Si2nSwRwTdM0e9QEsnnQxD0uThQ8xNE-BEvE-LuViwEXnH6_QC6fHDK_P9gp9_3zz7fquuf96--X6031jOOWl4RY6Rgem-xYGR6UFC9qB0JLogQF1zBrjuAbREcltK4gl0NPOiK7llMr2Cr0_1a1r_5whFzX5bGAcT3urTmyk7Din_ycZkZ0goq8kPZEmxZwTOLVPftLpoChRi3Bqp6pwahFuCZHjHG_P1edhAvuU8UepCrw7AzobPbpUr-vzX66VpJVsaf7xxEG92qOHpLLxUJWwPoEpykb_jzF-A0a7uZQ</recordid><startdate>20110202</startdate><enddate>20110202</enddate><creator>McNeilly, Alison D.</creator><creator>Williamson, Ritchie</creator><creator>Sutherland, Calum</creator><creator>Balfour, David J.K.</creator><creator>Stewart, Caroline A.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20110202</creationdate><title>High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task</title><author>McNeilly, Alison D. ; Williamson, Ritchie ; Sutherland, Calum ; Balfour, David J.K. ; Stewart, Caroline A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-4de821b2a93ebf17dedeafe5a70ab2e1f2dccf4ae58074d350d0e918c58341173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Cognition - drug effects</topic><topic>Conditioning, Operant - drug effects</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diet</topic><topic>Dietary Fats - pharmacology</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Locomotor activity</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Medical sciences</topic><topic>Motor Activity - drug effects</topic><topic>Operant</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reinforcement Schedule</topic><topic>Watermaze</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McNeilly, Alison D.</creatorcontrib><creatorcontrib>Williamson, Ritchie</creatorcontrib><creatorcontrib>Sutherland, Calum</creatorcontrib><creatorcontrib>Balfour, David J.K.</creatorcontrib><creatorcontrib>Stewart, Caroline A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McNeilly, Alison D.</au><au>Williamson, Ritchie</au><au>Sutherland, Calum</au><au>Balfour, David J.K.</au><au>Stewart, Caroline A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2011-02-02</date><risdate>2011</risdate><volume>217</volume><issue>1</issue><spage>134</spage><epage>141</epage><pages>134-141</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>▶ High fat feeding (HFF) reduces peripheral insulin sensitivity in out-bred rats. ▶ HFF impairs an operant, but not a watermaze, delayed matching to position task. ▶ Effect of HFF is greater when the rule is switched from matching to non-matching. ▶ Cognitive deficit correlates with insulin sensitivity but not body weight.
Obesity is the single greatest risk factor for the development of Type 2 diabetes mellitus (T2DM), with the prevalence of both dramatically increasing in recent years. These conditions are associated with medical complications such as hypertension, neuropathy and cardiovascular disease. Recent evidence also suggests a greater risk of developing dementia including Alzheimer's disease. The molecular mechanisms governing these changes remain obscure, although epidemiological evidence suggests that reduced insulin sensitivity (a characteristic of T2DM) is an independent risk factor for Alzheimer's disease. Here we examine the effects of diet-induced insulin resistance on cognitive ability in an animal model not predisposed to develop Alzheimer's pathology. Following 12 weeks on a high fat diet (45% of calories as crude fat) male Wistar rats were overweight and insulin resistant but not frankly diabetic. High fat fed animals were consistently poorer in all aspects of an operant based delayed matching to position task, yet were not impaired in spatial working memory as judged by the open field watermaze test. The cognitive deficit of the HF fed animals was most apparent when the task was switched from matching to non-matching to position, suggestive of an inability to change contingency. Performance in this task was negatively correlated with whole body insulin sensitivity but not weight gain. In conclusion this study has shown that insulin resistant animals exhibit impairments in an operant measure of behavioural flexibility which precede the development of diabetes.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>20974195</pmid><doi>10.1016/j.bbr.2010.10.017</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Behavioral psychophysiology Biological and medical sciences Blood Glucose - metabolism Cognition - drug effects Conditioning, Operant - drug effects Diabetes Diabetes. Impaired glucose tolerance Diet Dietary Fats - pharmacology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fundamental and applied biological sciences. Psychology Glucose Insulin - blood Insulin Resistance Locomotor activity Male Maze Learning - drug effects Medical sciences Motor Activity - drug effects Operant Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Reinforcement Schedule Watermaze |
| title | High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task |
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